Synergistic effects of nelfinavir and bortezomib on proteotoxic death of NSCLC and multiple myeloma cells
about
The 26S proteasome is a multifaceted target for anti-cancer therapiesNelfinavir and other protease inhibitors in cancer: mechanisms involved in anticancer activityA strategy for the identification of combinatorial bioactive compounds contributing to the holistic effect of herbal medicines.Rapamycin downregulates thymidylate synthase and potentiates the activity of pemetrexed in non-small cell lung cancer.Insights into the broad cellular effects of nelfinavir and the HIV protease inhibitors supporting their role in cancer treatment and preventionThe HIV protease inhibitor, nelfinavir, as a novel therapeutic approach for the treatment of refractory pediatric leukemia.Usp9x- and Noxa-mediated Mcl-1 downregulation contributes to pemetrexed-induced apoptosis in human non-small-cell lung cancer cellsPlasma cell disorders in HIV-infected patients: epidemiology and molecular mechanisms.A phase I trial of the HIV protease inhibitor nelfinavir in adults with solid tumorsAn inhibitor of HIV-1 protease modulates constitutive eIF2α dephosphorylation to trigger a specific integrated stress response.Nelfinavir suppresses insulin signaling and nitric oxide production by human aortic endothelial cells: protective effects of thiazolidinedionesNelfinavir augments proteasome inhibition by bortezomib in myeloma cells and overcomes bortezomib and carfilzomib resistance.The role of endoplasmic reticulum stress in maintaining and targeting multiple myeloma: a double-edged sword of adaptation and apoptosis.Is nelfinavir exposure associated with cancer incidence in HIV-positive individuals?Mechanisms of proteasome inhibitor-induced cytotoxicity in malignant glioma.Screening for E3-ubiquitin ligase inhibitors: challenges and opportunities.Recent advances and future directions in targeting the secretory apparatus in multiple myeloma.Sequence-specific alterations of epitope production by HIV protease inhibitors.HIF2α-Dependent Lipid Storage Promotes Endoplasmic Reticulum Homeostasis in Clear-Cell Renal Cell Carcinoma.Positive transcription elongation factor b (P-TEFb) is a therapeutic target in human multiple myeloma.Rapamycin sensitizes cancer cells to growth inhibition by the PARP inhibitor olaparib.ATF3-mediated NRF2/HO-1 signaling regulates TLR4 innate immune responses in mouse liver ischemia/reperfusion injury.Perturbation of proteasome function by bortezomib leading to ER stress-induced apoptotic cell death in cholangiocarcinoma.
P2860
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P2860
Synergistic effects of nelfinavir and bortezomib on proteotoxic death of NSCLC and multiple myeloma cells
description
2012 nî lūn-bûn
@nan
2012年の論文
@ja
2012年論文
@yue
2012年論文
@zh-hant
2012年論文
@zh-hk
2012年論文
@zh-mo
2012年論文
@zh-tw
2012年论文
@wuu
2012年论文
@zh
2012年论文
@zh-cn
name
Synergistic effects of nelfina ...... CLC and multiple myeloma cells
@ast
Synergistic effects of nelfina ...... CLC and multiple myeloma cells
@en
type
label
Synergistic effects of nelfina ...... CLC and multiple myeloma cells
@ast
Synergistic effects of nelfina ...... CLC and multiple myeloma cells
@en
prefLabel
Synergistic effects of nelfina ...... CLC and multiple myeloma cells
@ast
Synergistic effects of nelfina ...... CLC and multiple myeloma cells
@en
P2093
P2860
P356
P1476
Synergistic effects of nelfina ...... CLC and multiple myeloma cells
@en
P2093
J Lopiccolo
J R Mercado-Matos
M C Hollander
P A Dennis
S Kawabata
P2860
P2888
P356
10.1038/CDDIS.2012.87
P577
2012-07-19T00:00:00Z
P5875
P6179
1034920074