Increased levels of thiols protect antimony unresponsive Leishmania donovani field isolates against reactive oxygen species generated by trivalent antimony
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Whole genome sequencing of multiple Leishmania donovani clinical isolates provides insights into population structure and mechanisms of drug resistanceStudies of the Effectiveness of Bisphosphonate and Vanadium-Bisphosphonate Compounds In Vitro against Axenic Leishmania tarentolae.Plasmodium falciparum metacaspase PfMCA-1 triggers a z-VAD-fmk inhibitable protease to promote cell deathPlasticity of the Leishmania genome leading to gene copy number variations and drug resistanceDihydro-orotate dehydrogenase is physically associated with the respiratory complex and its loss leads to mitochondrial dysfunctionLinking in vitro and in vivo survival of clinical Leishmania donovani strainsGene expression profiling and molecular characterization of antimony resistance in Leishmania amazonensisMolecular mechanisms of drug resistance in natural Leishmania populations vary with genetic backgroundRole of efflux pumps and intracellular thiols in natural antimony resistant isolates of Leishmania donovaniProteomic and genomic analyses of antimony resistant Leishmania infantum mutantStage-dependent expression and up-regulation of trypanothione synthetase in amphotericin B resistant Leishmania donovaniAntimony transport mechanisms in resistant leishmania parasites.Intracellular zinc flux causes reactive oxygen species mediated mitochondrial dysfunction leading to cell death in Leishmania donovani.Reactive oxygen species scavenging by catalase is important for female Lutzomyia longipalpis fecundity and mortalityLeishmania amazonensis amastigotes highly express a tryparedoxin peroxidase isoform that increases parasite resistance to macrophage antimicrobial defenses and fosters parasite virulence.Functional analysis of cytosolic tryparedoxin peroxidase in antimony-resistant and -susceptible Leishmania braziliensis and Leishmania infantum lines.Antimony resistance in leishmania, focusing on experimental research.Upregulation of Cysteine Synthase and Cystathionine β-Synthase Contributes to Leishmania braziliensis Survival under Oxidative Stress.Deprivation of L-Arginine Induces Oxidative Stress Mediated Apoptosis in Leishmania donovani Promastigotes: Contribution of the Polyamine PathwayA new ABC half-transporter in Leishmania major is involved in resistance to antimony.Antimony resistance and environment: Elusive links to explore during Leishmania life cycle.Involvement of nucleoside diphosphate kinase b and elongation factor 2 in Leishmania braziliensis antimony resistance phenotypeDeciphering the interplay between cysteine synthase and thiol cascade proteins in modulating Amphotericin B resistance and survival of Leishmania donovani under oxidative stress.Methylglyoxal metabolism in trypanosomes and leishmania.Leishmania antimony resistance: what we know what we can learn from the field.Drug-resistant microorganisms with a higher fitness--can medicines boost pathogens?The 8-aminoquinoline analogue sitamaquine causes oxidative stress in Leishmania donovani promastigotes by targeting succinate dehydrogenase.Gene expression modulation is associated with gene amplification, supernumerary chromosomes and chromosome loss in antimony-resistant Leishmania infantum.Comparison of gene expression patterns among Leishmania braziliensis clinical isolates showing a different in vitro susceptibility to pentavalent antimony.A3K2A3-induced apoptotic cell death of Leishmania amazonensis occurs through caspase- and ATP-dependent mitochondrial dysfunction.Simple colorimetric trypanothione reductase-based assay for high-throughput screening of drugs against Leishmania intracellular amastigotes.Berberine chloride causes a caspase-independent, apoptotic-like death in Leishmania donovani promastigotes.Roles of trypanothione S-transferase and tryparedoxin peroxidase in resistance to antimonialsThe overexpression of genes of thiol metabolism contribute to drug resistance in clinical isolates of visceral leishmaniasis (kala azar) in India.Mitochondrial Proteomics of Antimony and Miltefosine Resistant Leishmania infantum.Elevated levels of tryparedoxin peroxidase in antimony unresponsive Leishmania donovani field isolates.Monitoring of intracellular nitric oxide in leishmaniasis: its applicability in patients with visceral leishmaniasis.Attenuation of oxidative stress by allylpyrocatechol in synovial cellular infiltrate of patients with Rheumatoid Arthritis.Decreased antimony uptake and overexpression of genes of thiol metabolism are associated with drug resistance in a canine isolate of Leishmania infantum.Iron enhances generation of free radicals by Artemisinin causing a caspase-independent, apoptotic death in Leishmania donovani promastigotes.
P2860
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P2860
Increased levels of thiols protect antimony unresponsive Leishmania donovani field isolates against reactive oxygen species generated by trivalent antimony
description
2007 nî lūn-bûn
@nan
2007年の論文
@ja
2007年論文
@yue
2007年論文
@zh-hant
2007年論文
@zh-hk
2007年論文
@zh-mo
2007年論文
@zh-tw
2007年论文
@wuu
2007年论文
@zh
2007年论文
@zh-cn
name
Increased levels of thiols pro ...... enerated by trivalent antimony
@ast
Increased levels of thiols pro ...... enerated by trivalent antimony
@en
type
label
Increased levels of thiols pro ...... enerated by trivalent antimony
@ast
Increased levels of thiols pro ...... enerated by trivalent antimony
@en
prefLabel
Increased levels of thiols pro ...... enerated by trivalent antimony
@ast
Increased levels of thiols pro ...... enerated by trivalent antimony
@en
P2093
P2860
P1433
P1476
Increased levels of thiols pro ...... enerated by trivalent antimony
@en
P2093
A H Fairlamb
M Chatterjee
P2860
P304
P356
10.1017/S0031182007003150
P577
2007-07-05T00:00:00Z