CAR, the continuously advancing receptor, in drug metabolism and disease.
about
Gene expression profiling reveals a regulatory role for ROR alpha and ROR gamma in phase I and phase II metabolismEffect of CAR activation on selected metabolic pathways in normal and hyperlipidemic mouse livers.Intestinal microbiota regulate xenobiotic metabolism in the liver.A single amino acid controls the functional switch of human constitutive androstane receptor (CAR) 1 to the xenobiotic-sensitive splicing variant CAR3.Proteasomal interaction as a critical activity modulator of the human constitutive androstane receptor.A wheel of time: the circadian clock, nuclear receptors, and physiology.Generation of ES cells for conditional expression of nuclear receptors and coregulators in vivo.Constitutive androstane receptor activation decreases plasma apolipoprotein B-containing lipoproteins and atherosclerosis in low-density lipoprotein receptor-deficient mice.Garlic extract diallyl sulfide (DAS) activates nuclear receptor CAR to induce the Sult1e1 gene in mouse liver.Activation of CAR and PXR by Dietary, Environmental and Occupational Chemicals Alters Drug Metabolism, Intermediary Metabolism, and Cell Proliferation.Principles of liver regeneration and growth homeostasis.Regulation of drug-metabolizing enzymes by xenobiotic receptors: PXR and CAR.Differential activation of pregnane X receptor and constitutive androstane receptor by buprenorphine in primary human hepatocytes and HepG2 cells.CYP2B6: new insights into a historically overlooked cytochrome P450 isozymeModulation of constitutive androstane receptor (CAR) and pregnane X receptor (PXR) by 6-arylpyrrolo[2,1-d][1,5]benzothiazepine derivatives, ligands of peripheral benzodiazepine receptor (PBR).Drug metabolizing enzyme induction pathways in experimental non-alcoholic steatohepatitis.Retinoid-related orphan receptors (RORs): critical roles in development, immunity, circadian rhythm, and cellular metabolismQuantitative high-throughput identification of drugs as modulators of human constitutive androstane receptor.Foxa1 and Foxa2 are essential for sexual dimorphism in liver cancerAn insulin-like growth factor 1 receptor inhibitor induces CYP3A4 expression through a pregnane X receptor-independent, noncanonical constitutive androstane receptor-related mechanism.Daphnia HR96 is a promiscuous xenobiotic and endobiotic nuclear receptorThe environmental estrogen, nonylphenol, activates the constitutive androstane receptor.Neonatal activation of the nuclear receptor CAR results in epigenetic memory and permanent change of drug metabolism in mouse liverGenome-wide analysis of human constitutive androstane receptor (CAR) transcriptome in wild-type and CAR-knockout HepaRG cellsSynthetic drugs and natural products as modulators of constitutive androstane receptor (CAR) and pregnane X receptor (PXR).The constitutive androstane receptor is a novel therapeutic target facilitating cyclophosphamide-based treatment of hematopoietic malignanciesIdentification of novel activators of constitutive androstane receptor from FDA-approved drugs by integrated computational and biological approaches.The role of cytochrome P450 enzymes in endogenous signalling pathways and environmental carcinogenesis.Crosstalk between xenobiotics metabolism and circadian clock.Physiological function of PARbZip circadian clock-controlled transcription factors.Nuclear receptors, metabolism, and the circadian clock.Nuclear translocation of adenoviral-enhanced yellow fluorescent protein-tagged-human constitutive androstane receptor (hCAR): a novel tool for screening hCAR activators in human primary hepatocytes.Current industrial practices in assessing CYP450 enzyme induction: preclinical and clinicalHepatic drug transporters and nuclear receptors: regulation by therapeutic agents.Oxazaphosphorine bioactivation and detoxification The role of xenobiotic receptors.Activation of nuclear receptor CAR ameliorates diabetes and fatty liver disease.Dephosphorylation of threonine 38 is required for nuclear translocation and activation of human xenobiotic receptor CAR (NR1I3).Signals and cells involved in regulating liver regeneration.Utility of B-13 progenitor-derived hepatocytes in hepatotoxicity and genotoxicity studiesMetformin represses drug-induced expression of CYP2B6 by modulating the constitutive androstane receptor signaling.
P2860
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P2860
CAR, the continuously advancing receptor, in drug metabolism and disease.
description
2005 nî lūn-bûn
@nan
2005年の論文
@ja
2005年論文
@yue
2005年論文
@zh-hant
2005年論文
@zh-hk
2005年論文
@zh-mo
2005年論文
@zh-tw
2005年论文
@wuu
2005年论文
@zh
2005年论文
@zh-cn
name
CAR, the continuously advancing receptor, in drug metabolism and disease.
@ast
CAR, the continuously advancing receptor, in drug metabolism and disease.
@en
type
label
CAR, the continuously advancing receptor, in drug metabolism and disease.
@ast
CAR, the continuously advancing receptor, in drug metabolism and disease.
@en
prefLabel
CAR, the continuously advancing receptor, in drug metabolism and disease.
@ast
CAR, the continuously advancing receptor, in drug metabolism and disease.
@en
P356
P1476
CAR, the continuously advancing receptor, in drug metabolism and disease.
@en
P2093
P304
P356
10.2174/1389200054633899
P407
P577
2005-08-01T00:00:00Z