Phospholipase D2-dependent inhibition of the nuclear hormone receptor PPARgamma by cyclic phosphatidic acid.
about
Mammalian phospholipase D physiological and pathological rolesLipidome in colorectal cancerRevealing a steroid receptor ligand as a unique PPARγ agonistStructural evidence of the species-dependent albumin binding of the modified cyclic phosphatidic acid with cytotoxic propertiesPotential of Natural Products in the Inhibition of Adipogenesis through Regulation of PPARγ Expression and/or Its Transcriptional ActivityPhospholipases D1 and D2 Suppress Appetite and Protect against OverweightLysophosphatidic acid activates peroxisome proliferator activated receptor-γ in CHO cells that over-express glycerol 3-phosphate acyltransferase-1The mito-DAMP cardiolipin blocks IL-10 production causing persistent inflammation during bacterial pneumoniaCellular and physiological roles for phospholipase D1 in cancer.Structural determinants of the transient receptor potential 1 (TRPV1) channel activation by phospholipid analogsLysophosphatidic acid in atherosclerotic diseasesAiming drug discovery at lysophosphatidic acid targets.Phospholipase D toxins of brown spider venom convert lysophosphatidylcholine and sphingomyelin to cyclic phosphatesEndogenous ligands for nuclear receptors: digging deeper.Deficiencies of the lipid-signaling enzymes phospholipase D1 and D2 alter cytoskeletal organization, macrophage phagocytosis, and cytokine-stimulated neutrophil recruitment.PTB-associated splicing factor (PSF) is a PPARγ-binding protein and growth regulator of colon cancer cells.The phospholipase A1 activity of lysophospholipase A-I links platelet activation to LPA production during blood coagulationCyclic phosphatidic acid stimulates cAMP production and inhibits growth in human colon cancer cells.Phospholipase D: enzymology, functionality, and chemical modulationLipin-1 phosphatidic phosphatase activity modulates phosphatidate levels to promote peroxisome proliferator-activated receptor γ (PPARγ) gene expression during adipogenesis.Pharmacological repression of PPARγ promotes osteogenesisPhosphatidic Acid (PA) can Displace PPARα/LXRα Binding to The EGFR Promoter Causing its Transrepression in Luminal Cancer CellsAlterations in lipid signaling underlie lipodystrophy secondary to AGPAT2 mutations.PPAR γ Networks in Cell Signaling: Update and Impact of Cyclic Phosphatidic Acid.CDP-diacylglycerol synthases regulate the growth of lipid droplets and adipocyte development.Roles for the lipid-signaling enzyme MitoPLD in mitochondrial dynamics, piRNA biogenesis, and spermatogenesis.PLD1 regulates adipogenic differentiation through mTOR - IRS-1 phosphorylation at serine 636/639.Phospholipase D (PLD) drives cell invasion, tumor growth and metastasis in a human breast cancer xenograph model.Take-over: multiple mechanisms of inter-adipocyte communication.Nuclear sphingolipid metabolism.Blocking the peroxisome proliferator-activated receptor (PPAR): an overview.Disentangling biological signaling networks by dynamic coupling of signaling lipids to modifying enzymes.Modes-of-Action Related to Repeated Dose Toxicity: Tissue-Specific Biological Roles of PPAR γ Ligand-Dependent Dysregulation in Nonalcoholic Fatty Liver Disease.Phospholipid regulation of the nuclear receptor superfamily.Release of cyclic phosphatidic acid from gelatin-based hydrogels inhibit colon cancer cell growth and migration.The PTB-Associated Splicing Factor/Peroxisome Proliferator-Activated Receptor Gamma Axis Regulates Autophagosome Formation in Human Pancreatic Cancer Cells.PPARs and lipid ligands in inflammation and metabolism.The Role of PPARγ in the Transcriptional Control by Agonists and Antagonists.Cyclic phosphatidic acid inhibits alkyl-glycerophosphate-induced downregulation of histone deacetylase 2 expression and suppresses the inflammatory response in human coronary artery endothelial cells.A metabolomics strategy for detecting protein-metabolite interactions to identify natural nuclear receptor ligands.
P2860
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P2860
Phospholipase D2-dependent inhibition of the nuclear hormone receptor PPARgamma by cyclic phosphatidic acid.
description
2010 nî lūn-bûn
@nan
2010年の論文
@ja
2010年論文
@yue
2010年論文
@zh-hant
2010年論文
@zh-hk
2010年論文
@zh-mo
2010年論文
@zh-tw
2010年论文
@wuu
2010年论文
@zh
2010年论文
@zh-cn
name
Phospholipase D2-dependent inh ...... a by cyclic phosphatidic acid.
@ast
Phospholipase D2-dependent inh ...... a by cyclic phosphatidic acid.
@en
type
label
Phospholipase D2-dependent inh ...... a by cyclic phosphatidic acid.
@ast
Phospholipase D2-dependent inh ...... a by cyclic phosphatidic acid.
@en
prefLabel
Phospholipase D2-dependent inh ...... a by cyclic phosphatidic acid.
@ast
Phospholipase D2-dependent inh ...... a by cyclic phosphatidic acid.
@en
P2093
P2860
P1433
P1476
Phospholipase D2-dependent inh ...... a by cyclic phosphatidic acid.
@en
P2093
Abby L Parrill
Alyssa Bolen
Ayako Uchiyama
Chunxiang Zhang
Daniel L Baker
Gabor Tigyi
Guangwei Du
Huazhang Guo
Junming Yue
P2860
P304
P356
10.1016/J.MOLCEL.2010.07.022
P577
2010-08-01T00:00:00Z