A novel pathway down-modulating T cell activation involves HPK-1-dependent recruitment of 14-3-3 proteins on SLP-76.
about
Function, regulation and pathological roles of the Gab/DOS docking proteinsSequential phosphorylation of SLP-76 at tyrosine 173 is required for activation of T and mast cellsA THEMIS:SHP1 complex promotes T-cell survivalDissection of a signaling pathway by which pathogen-associated molecular patterns recruit the JNK and p38 MAPKs and trigger cytokine releaseThe kinase GLK controls autoimmunity and NF-κB signaling by activating the kinase PKC-θ in T cellsT cell activationGerminal-center kinase-like kinase co-crystal structure reveals a swapped activation loop and C-terminal extensionSLP-65 phosphorylation dynamics reveals a functional basis for signal integration by receptor-proximal adaptor proteinsQuantitative proteomics analysis of signalosome dynamics in primary T cells identifies the surface receptor CD6 as a Lat adaptor-independent TCR signaling hubSH2 domain containing leukocyte phosphoprotein of 76-kDa (SLP-76) feedback regulation of ZAP-70 microclustering.Release of serine/threonine-phosphorylated adaptors from signaling microclusters down-regulates T cell activation.Down-regulation of B cell receptor signaling by hematopoietic progenitor kinase 1 (HPK1)-mediated phosphorylation and ubiquitination of activated B cell linker protein (BLNK).Serine Phosphorylation of SLP76 Is Dispensable for T Cell Development but Modulates Helper T Cell Function.Attenuation of T cell receptor signaling by serine phosphorylation-mediated lysine 30 ubiquitination of SLP-76 protein.Quantitative dynamics of phosphoproteome: the devil is in the details.Nuclear translocation of MEK1 triggers a complex T cell response through the corepressor silencing mediator of retinoid and thyroid hormone receptor.A new look at T cell receptor signaling to nuclear factor-κBSLP-76 sterile α motif (SAM) and individual H5 α helix mediate oligomer formation for microclusters and T-cell activation.SKAP-55, SKAP-55-related and ADAP adaptors modulate integrin-mediated immune-cell adhesion.The importance of Src homology 2 domain-containing leukocyte phosphoprotein of 76 kilodaltons sterile-alpha motif domain in thymic selection and T-cell activation.Phosphorylation of CARMA1 by HPK1 is critical for NF-kappaB activation in T cells.The Role of SH2 Domain-containing Leukocyte Phosphoprotein of 76 kDa in the Regulation of Immune Cell Development and FunctionCoordination of receptor signaling in multiple hematopoietic cell lineages by the adaptor protein SLP-76The LAT story: a tale of cooperativity, coordination, and choreography.Cytoskeletal cross-talk in the control of T cell antigen receptor signaling.Understanding signal integration through targeted mutations of an adapter protein.Mammalian MAPK signal transduction pathways activated by stress and inflammation: a 10-year update.Integrative biology of T cell activation.The SLP-76 Src homology 2 domain is required for T cell development and activation.The Immune Adaptor SLP-76 Binds to SUMO-RANGAP1 at Nuclear Pore Complex Filaments to Regulate Nuclear Import of Transcription Factors in T Cells.
P2860
Q21245511-ACC134E9-305D-4795-84BD-9C930DB6F651Q24310144-CE5F29AA-B6C8-40C0-8219-35906DF0DE0DQ24310969-F291D9F1-DCD2-40A0-B3FA-2B6E4F19D032Q24312954-343AF899-15C2-4003-A634-FCA8DD41EB72Q24339510-C56C9283-8065-4113-93D7-1F0AB6C8BD76Q24658051-834A8E98-9952-4A46-88B4-1B23E31DD032Q27728461-EB6DF62C-40A9-4884-8206-0C2D7D7ECC80Q28241530-1C808B62-A0E9-48C1-B6F3-9D87463B4E77Q28771480-09B209C6-D9A8-4B66-9225-E4FED02D3DB5Q30495049-7F2CFFE7-CD1E-4E1E-935F-F6274D23C260Q35670715-C7223663-DDC5-4D94-A448-F2864D3CC29DQ35879604-0D17B89B-2394-4B6E-B42D-99AA057864EBQ36255620-A883CF4D-1EE5-47DC-B381-BC0E22F26B7BQ36298331-2E0A3005-9804-45E3-A2C0-6FBFE156C2C2Q36337579-97553CA0-7FDB-4A09-91A1-3DFE18F99805Q36490528-45E53181-DB4D-4D26-AF12-217133760106Q36906449-415B848F-B4DD-498A-9EDE-ECC82BFA8BD6Q37226140-8C3E9541-45B8-4DF4-878D-8BCFA602759AQ37257440-379DD82E-C221-43EC-A6DE-214B0492BDDEQ37262507-646E036C-6DC4-4055-BE2B-D6DF1CB2F84DQ37321154-CDFDC814-A0E7-47E5-9767-B89920E715B0Q37682609-4EDC8B1F-FD42-48F7-878E-C6A5A7112165Q37746483-5D7B2214-AA65-49DD-B6D1-B05766FE0F59Q37770817-287E944B-7680-4513-9571-92DB55DBA5BFQ37786677-63E425F5-DB6E-4EB8-A31A-A4BA58F657B1Q37802005-F2DE680C-FE0F-40B8-B6E4-A44D87ACA980Q38005668-4FC3367C-AD21-4806-97C9-0BA5AEE59FB7Q38241273-4E95400E-5DBA-4001-89D6-D327DC079763Q38829466-CF7F4E40-C9B4-4759-BCB6-078ADB2A950AQ38839497-E27E91FF-3301-44B2-B47E-CEACDCFFDF80
P2860
A novel pathway down-modulating T cell activation involves HPK-1-dependent recruitment of 14-3-3 proteins on SLP-76.
description
2007 nî lūn-bûn
@nan
2007年の論文
@ja
2007年学术文章
@wuu
2007年学术文章
@zh-cn
2007年学术文章
@zh-hans
2007年学术文章
@zh-my
2007年学术文章
@zh-sg
2007年學術文章
@yue
2007年學術文章
@zh
2007年學術文章
@zh-hant
name
A novel pathway down-modulatin ...... of 14-3-3 proteins on SLP-76.
@ast
A novel pathway down-modulatin ...... of 14-3-3 proteins on SLP-76.
@en
type
label
A novel pathway down-modulatin ...... of 14-3-3 proteins on SLP-76.
@ast
A novel pathway down-modulatin ...... of 14-3-3 proteins on SLP-76.
@en
prefLabel
A novel pathway down-modulatin ...... of 14-3-3 proteins on SLP-76.
@ast
A novel pathway down-modulatin ...... of 14-3-3 proteins on SLP-76.
@en
P2093
P2860
P50
P356
P1476
A novel pathway down-modulatin ...... t of 14-3-3 proteins on SLP-76
@en
P2093
Benjamin Montagne
Britta Jungwirth
Florent Carrette
Julien Fourtane
Oreste Acuto
Wolf D Lehmann
P2860
P304
P356
10.1084/JEM.20062066
P407
P50
P577
2007-03-12T00:00:00Z