Beta cell-specific deficiency of the stimulatory G protein alpha-subunit Gsalpha leads to reduced beta cell mass and insulin-deficient diabetes.
about
Rap1 promotes multiple pancreatic islet cell functions and signals through mammalian target of rapamycin complex 1 to enhance proliferationMitochondrial dysfunction and oxidative stress mediate the physiological impairment induced by the disruption of autophagyPancreas-specific Gsalpha deficiency has divergent effects on pancreatic alpha- and beta-cell proliferationThe role of GNAS and other imprinted genes in the development of obesity.Age-related impairment in insulin release: the essential role of β(2)-adrenergic receptor.Repurposing cAMP-modulating medications to promote β-cell replication.Whole genome SNP genotyping and exome sequencing reveal novel genetic variants and putative causative genes in congenital hyperinsulinism.Effects of deficiency of the G protein Gsα on energy and glucose homeostasisThe role of incretins in glucose homeostasis and diabetes treatment.Activation of the GLP-1 receptor signalling pathway: a relevant strategy to repair a deficient beta-cell massSevere obesity and insulin resistance due to deletion of the maternal Gsalpha allele is reversed by paternal deletion of the Gsalpha imprint control region.Liver-specific disruption of the murine glucagon receptor produces α-cell hyperplasia: evidence for a circulating α-cell growth factor.Exendin-4 stimulation of cyclin A2 in beta-cell proliferation.Minireview: Meeting the demand for insulin: molecular mechanisms of adaptive postnatal beta-cell mass expansionPhysiological dysfunctions associated with mutations of the imprinted Gnas locus.Reduced insulin sensitivity in adults with pseudohypoparathyroidism type 1a.Heterotrimeric G proteins and apoptosis: intersecting signaling pathways leading to context dependent phenotypesMolecular mechanisms underlying physiological and receptor pleiotropic effects mediated by GLP-1R activation.Gastrointestinal hormones and the regulation of β-cell mass.Regulator of G protein signaling 2 is a key regulator of pancreatic β-cell mass and function.GLP-1 signalling compensates for impaired insulin signalling in regulating beta cell proliferation in βIRKO mice.Feedback inhibition of CREB signaling promotes beta cell dysfunction in insulin resistance.The Gq/G11-mediated signaling pathway is critical for autocrine potentiation of insulin secretion in miceLeptin deficiency and beta-cell dysfunction underlie type 2 diabetes in compound Akt knockout mice.Incretin-Based Therapies: Revisiting Their Mode of Action.Inhibition of TBK1/IKKε Promotes Regeneration of Pancreatic β-cells
P2860
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P2860
Beta cell-specific deficiency of the stimulatory G protein alpha-subunit Gsalpha leads to reduced beta cell mass and insulin-deficient diabetes.
description
2007 nî lūn-bûn
@nan
2007年の論文
@ja
2007年学术文章
@wuu
2007年学术文章
@zh-cn
2007年学术文章
@zh-hans
2007年学术文章
@zh-my
2007年学术文章
@zh-sg
2007年學術文章
@yue
2007年學術文章
@zh
2007年學術文章
@zh-hant
name
Beta cell-specific deficiency ...... nd insulin-deficient diabetes.
@ast
Beta cell-specific deficiency ...... nd insulin-deficient diabetes.
@en
type
label
Beta cell-specific deficiency ...... nd insulin-deficient diabetes.
@ast
Beta cell-specific deficiency ...... nd insulin-deficient diabetes.
@en
prefLabel
Beta cell-specific deficiency ...... nd insulin-deficient diabetes.
@ast
Beta cell-specific deficiency ...... nd insulin-deficient diabetes.
@en
P2093
P2860
P356
P1476
Beta cell-specific deficiency ...... and insulin-deficient diabetes
@en
P2093
P2860
P304
19601-19606
P356
10.1073/PNAS.0704796104
P407
P577
2007-11-20T00:00:00Z