Allele-selective inhibition of trinucleotide repeat genes.
about
Exploring the effect of sequence length and composition on allele-selective inhibition of human huntingtin expression by single-stranded silencing RNAsSynthesis and biophysical properties of C5-functionalized LNA (locked nucleic acid).C5-alkynyl-functionalized α-L-LNA: synthesis, thermal denaturation experiments and enzymatic stabilityCell-based therapies for Huntington's disease.Phosphorodiamidate morpholino oligomers suppress mutant huntingtin expression and attenuate neurotoxicity.Single-stranded RNAs use RNAi to potently and allele-selectively inhibit mutant huntingtin expression.Engineering Duplex RNAs for Challenging Targets: Recognition of GGGGCC/CCCCGG Repeats at the ALS/FTD C9orf72 LocusSynthetic zinc finger repressors reduce mutant huntingtin expression in the brain of R6/2 mice.Mechanism of allele-selective inhibition of huntingtin expression by duplex RNAs that target CAG repeats: function through the RNAi pathwayDigital quantitation of potential therapeutic target RNAs.RNA duplexes with abasic substitutions are potent and allele-selective inhibitors of huntingtin and ataxin-3 expression.Allele-selective inhibition of expression of huntingtin and ataxin-3 by RNA duplexes containing unlocked nucleic acid substitutions.Mutant CAG Repeats Effectively Targeted by RNA Interference in SCA7 Cells.Synthesis and characterization of oligodeoxyribonucleotides modified with 2'-amino-α-L-LNA adenine monomers: high-affinity targeting of single-stranded DNAExpanded complexity of unstable repeat diseases.Targeting CAG repeat RNAs reduces Huntington's disease phenotype independently of huntingtin levels.Silencing mutant huntingtin by adeno-associated virus-mediated RNA interference ameliorates disease manifestations in the YAC128 mouse model of Huntington's disease.Self-duplexing CUG repeats selectively inhibit mutant huntingtin expressionPeptide-mediated Cell and In Vivo Delivery of Antisense Oligonucleotides and siRNA.
P2860
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P2860
Allele-selective inhibition of trinucleotide repeat genes.
description
2012 nî lūn-bûn
@nan
2012年の論文
@ja
2012年学术文章
@wuu
2012年学术文章
@zh-cn
2012年学术文章
@zh-hans
2012年学术文章
@zh-my
2012年学术文章
@zh-sg
2012年學術文章
@yue
2012年學術文章
@zh
2012年學術文章
@zh-hant
name
Allele-selective inhibition of trinucleotide repeat genes.
@ast
Allele-selective inhibition of trinucleotide repeat genes.
@en
type
label
Allele-selective inhibition of trinucleotide repeat genes.
@ast
Allele-selective inhibition of trinucleotide repeat genes.
@en
prefLabel
Allele-selective inhibition of trinucleotide repeat genes.
@ast
Allele-selective inhibition of trinucleotide repeat genes.
@en
P2860
P1433
P1476
Allele-selective inhibition of trinucleotide repeat genes.
@en
P2093
David R Corey
Masayuki Matsui
P2860
P304
P356
10.1016/J.DRUDIS.2012.01.006
P577
2012-01-18T00:00:00Z