Polymer scaling laws of unfolded and intrinsically disordered proteins quantified with single-molecule spectroscopy
about
Cooperative unfolding of compact conformations of the intrinsically disordered protein osteopontinInsights into Coupled Folding and Binding Mechanisms from Kinetic StudiesPhysicochemical properties of cells and their effects on intrinsically disordered proteins (IDPs)Relating sequence encoded information to form and function of intrinsically disordered proteinsEnergetically significant networks of coupled interactions within an unfolded proteinEffects of Mutations on the Reconfiguration Rate of α-SynucleinIntrinsically disordered proteins drive membrane curvatureMicrosecond barrier-limited chain collapse observed by time-resolved FRET and SAXS.Collapse of a long axis: single-molecule Förster resonance energy transfer and serpin equilibrium unfolding.Discriminating binding mechanisms of an intrinsically disordered protein via a multi-state coarse-grained model.Theoretical and computational validation of the Kuhn barrier friction mechanism in unfolded proteins.Probing the average local structure of biomolecules using small-angle scattering and scaling laws.Modulation of frustration in folding by sequence permutation.Hamiltonian Switch Metropolis Monte Carlo Simulations for Improved Conformational Sampling of Intrinsically Disordered Regions Tethered to Ordered Domains of Proteins.Single-molecule spectroscopy reveals chaperone-mediated expansion of substrate protein.Conformations of intrinsically disordered proteins are influenced by linear sequence distributions of oppositely charged residuesQuantitative assessments of the distinct contributions of polypeptide backbone amides versus side chain groups to chain expansion via chemical denaturationBalanced Protein-Water Interactions Improve Properties of Disordered Proteins and Non-Specific Protein AssociationRole of denatured-state properties in chaperonin action probed by single-molecule spectroscopyForce-induced unzipping transitions in an athermal crowded environment.The binding mechanisms of intrinsically disordered proteins.The assembly dynamics of the cytolytic pore toxin ClyA.Intrinsically disordered proteins in cellular signalling and regulation.Random coil negative control reproduces the discrepancy between scattering and FRET measurements of denatured protein dimensions.Force field-dependent solution properties of glycine oligomersResolution of Two Sub-Populations of Conformers and Their Individual Dynamics by Time Resolved Ensemble Level FRET Measurements.Protein folding guides disulfide bond formationConformational Dynamics of Two Natively Unfolded Fragment Peptides: Comparison of the AMBER and CHARMM Force Fields.From sequence and forces to structure, function, and evolution of intrinsically disordered proteinsLocalizing internal friction along the reaction coordinate of protein folding by combining ensemble and single-molecule fluorescence spectroscopyExperiments and simulations show how long-range contacts can form in expanded unfolded proteins with negligible secondary structureDimensions, energetics, and denaturant effects of the protein unstructured stateA quantitative measure for protein conformational heterogeneityProtein Composition Determines the Effect of Crowding on the Properties of Disordered Proteins.Single-molecule FRET reveals the native-state dynamics of the IκBα ankyrin repeat domainComprehensive structural and dynamical view of an unfolded protein from the combination of single-molecule FRET, NMR, and SAXS.Single-molecule spectroscopy reveals polymer effects of disordered proteins in crowded environments.Temperature-dependent solvation modulates the dimensions of disordered proteins.Deciphering Complexity in Molecular Biophysics with Single-Molecule Resolution.Modulation of Intrinsically Disordered Protein Function by Post-translational Modifications.
P2860
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P2860
Polymer scaling laws of unfolded and intrinsically disordered proteins quantified with single-molecule spectroscopy
description
2012 nî lūn-bûn
@nan
2012年の論文
@ja
2012年学术文章
@wuu
2012年学术文章
@zh-cn
2012年学术文章
@zh-hans
2012年学术文章
@zh-my
2012年学术文章
@zh-sg
2012年學術文章
@yue
2012年學術文章
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2012年學術文章
@zh-hant
name
Polymer scaling laws of unfold ...... h single-molecule spectroscopy
@ast
Polymer scaling laws of unfold ...... h single-molecule spectroscopy
@en
type
label
Polymer scaling laws of unfold ...... h single-molecule spectroscopy
@ast
Polymer scaling laws of unfold ...... h single-molecule spectroscopy
@en
prefLabel
Polymer scaling laws of unfold ...... h single-molecule spectroscopy
@ast
Polymer scaling laws of unfold ...... h single-molecule spectroscopy
@en
P2093
P2860
P356
P1476
Polymer scaling laws of unfold ...... h single-molecule spectroscopy
@en
P2093
Alessandro Borgia
Daniel Nettels
Hagen Hofmann
Klaus Gast
P2860
P304
16155-16160
P356
10.1073/PNAS.1207719109
P407
P577
2012-09-14T00:00:00Z