Purified perforin induces target cell lysis but not DNA fragmentation.
about
A novel ligand in lymphocyte-mediated cytotoxicity: expression of the beta subunit of H+ transporting ATP synthase on the surface of tumor cell linesIdentification and functional characterization of a TIA-1-related nucleolysinSystematic characterization of human CD8+ T cells with natural killer cell markers in comparison with natural killer cells and normal CD8+ T cellsAnti-viral strategies of cytotoxic T lymphocytes are manifested through a variety of granule-bound pathways of apoptosis induction.Inhibition of lymphocyte mediated cytotoxicity by perforin antisense oligonucleotides.Identification of human granzyme B promoter regulatory elements interacting with activated T-cell-specific proteins: implication of Ikaros and CBF binding sites in promoter activation.Natural killer and lymphokine-activated killer cells require granzyme B for the rapid induction of apoptosis in susceptible target cells.Perforin: more than just a pore-forming protein.Raised granzyme B levels are associated with erosions in patients with early rheumatoid factor positive rheumatoid arthritis.A null mutation in the perforin gene impairs cytolytic T lymphocyte- and natural killer cell-mediated cytotoxicity.Residual active granzyme B in cathepsin C-null lymphocytes is sufficient for perforin-dependent target cell apoptosisInhibition of cytotoxic T lymphocyte-induced target cell DNA fragmentation, but not lysis, by inhibitors of DNA topoisomerases I and II.Separate metabolic pathways leading to DNA fragmentation and apoptotic chromatin condensationTransfection with the inducible nitric oxide synthase gene suppresses tumorigenicity and abrogates metastasis by K-1735 murine melanoma cells.Interleukin-1 beta-converting enzyme-like protease cleaves DNA-dependent protein kinase in cytotoxic T cell killing.Viral oncolysates as human tumor vaccines.The drug efflux protein, P-glycoprotein, additionally protects drug-resistant tumor cells from multiple forms of caspase-dependent apoptosis.Extracellular ATP as a trigger for apoptosis or programmed cell death.Target cell death triggered by cytotoxic T lymphocytes: a target cell mutant distinguishes passive pore formation and active cell suicide mechanismsNatural killer cells and antifungal host response.Genome digestion is a dispensable consequence of physiological cell death mediated by cytotoxic T lymphocytes.Perforin/granzyme-dependent and independent mechanisms are both important for the development of graft-versus-host disease after murine bone marrow transplantationCell death mechanisms and the immune system.Role of natural killer cells in antibacterial immunity.Novel path to apoptosis: small transmembrane pores created by staphylococcal alpha-toxin in T lymphocytes evoke internucleosomal DNA degradation.The role of apoptosis in bispecific antibody-mediated T-cell cytotoxicityGranzymes, cytotoxic granules and cell death: the early work of Dr. Jurg Tschopp.Perforin and lymphocyte-mediated cytolysis.Granzyme B plays a critical role in cytotoxic lymphocyte-induced apoptosis.Nuclear changes in the cytotoxic T lymphocyte-induced model of apoptosis.Killing by cytotoxic T cells and natural killer cells: multiple granule serine proteases as initiators of DNA fragmentation.Apoptosis overview emphasizing the role of oxidative stress, DNA damage and signal-transduction pathways.The influence of ultraviolet light on immunological cytotoxicity in the skin.A natural killer cell granule protein that induces DNA fragmentation and apoptosis.Susceptibility to cytotoxic T lymphocyte-induced apoptosis is a function of the proliferative status of the target.The perforin mediated apoptotic pathway in lung injury and fibrosis.Evidence for a perforin-mediated mechanism controlling cardiac inflammation in Trypanosoma cruzi infection.Permeability transition-independent release of mitochondrial cytochrome c induced by valinomycin.Natural Killer Cells in Antifungal Immunity.NK Cells and Their Role in Invasive Mold Infection.
P2860
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P2860
Purified perforin induces target cell lysis but not DNA fragmentation.
description
1989 nî lūn-bûn
@nan
1989年の論文
@ja
1989年学术文章
@wuu
1989年学术文章
@zh-cn
1989年学术文章
@zh-hans
1989年学术文章
@zh-my
1989年学术文章
@zh-sg
1989年學術文章
@yue
1989年學術文章
@zh
1989年學術文章
@zh-hant
name
Purified perforin induces target cell lysis but not DNA fragmentation.
@ast
Purified perforin induces target cell lysis but not DNA fragmentation.
@en
type
label
Purified perforin induces target cell lysis but not DNA fragmentation.
@ast
Purified perforin induces target cell lysis but not DNA fragmentation.
@en
prefLabel
Purified perforin induces target cell lysis but not DNA fragmentation.
@ast
Purified perforin induces target cell lysis but not DNA fragmentation.
@en
P2093
P2860
P356
P1476
Purified perforin induces target cell lysis but not DNA fragmentation.
@en
P2093
P2860
P304
P356
10.1084/JEM.170.4.1451
P407
P577
1989-10-01T00:00:00Z