AF4 uses the SL1 components of RNAP1 machinery to initiate MLL fusion- and AEP-dependent transcription.
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MLL-Rearranged Leukemias-An Update on Science and Clinical Approaches.MLL-AF4 binds directly to a BCL-2 specific enhancer and modulates H3K27 acetylationDDX6 transfers P-TEFb kinase to the AF4/AF4N (AFF1) super elongation complex.TBP loading by AF4 through SL1 is the major rate-limiting step in MLL fusion-dependent transcription.Cooperative gene activation by AF4 and DOT1L drives MLL-rearranged leukemia.Molecular processes involved in B cell acute lymphoblastic leukaemia.
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AF4 uses the SL1 components of RNAP1 machinery to initiate MLL fusion- and AEP-dependent transcription.
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AF4 uses the SL1 components of ...... d AEP-dependent transcription.
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AF4 uses the SL1 components of ...... d AEP-dependent transcription.
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AF4 uses the SL1 components of ...... d AEP-dependent transcription.
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AF4 uses the SL1 components of ...... d AEP-dependent transcription.
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AF4 uses the SL1 components of ...... d AEP-dependent transcription.
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AF4 uses the SL1 components of ...... d AEP-dependent transcription.
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AF4 uses the SL1 components of ...... d AEP-dependent transcription.
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Akihiko Yokoyama
Akinori Kanai
Hiroshi Okuda
Hirotaka Matsui
Shinji Ito
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10.1038/NCOMMS9869
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P577
2015-11-23T00:00:00Z