EZH2 Mediates epigenetic silencing of neuroblastoma suppressor genes CASZ1, CLU, RUNX3, and NGFR
about
Genome-wide DNA methylation analysis identifies MEGF10 as a novel epigenetically repressed candidate tumor suppressor gene in neuroblastomaPharmacological inhibition of EZH2 as a promising differentiation therapy in embryonal RMSRegulation and Role of EZH2 in CancerEssential role of the zinc finger transcription factor Casz1 for mammalian cardiac morphogenesis and developmentSMARCB1 protein and mRNA loss is not caused by promoter and histone hypermethylation in epithelioid sarcoma.Genomic pathway analysis reveals that EZH2 and HDAC4 represent mutually exclusive epigenetic pathways across human cancersIdentification and pharmacological inactivation of the MYCN gene network as a therapeutic strategy for neuroblastic tumor cellsRelationship of DNA methylation and gene expression in idiopathic pulmonary fibrosis.Quantitative nuclear proteomics identifies that miR-137-mediated EZH2 reduction regulates resveratrol-induced apoptosis of neuroblastoma cellsAscl1 phospho-status regulates neuronal differentiation in a Xenopus developmental model of neuroblastomaPolycomb-dependent repression of the potassium channel-encoding gene KCNA5 promotes cancer cell survival under conditions of stressALK and MYCN: when two oncogenes are better than one.Enhancer of zeste homolog 2 silencing inhibits tumor growth and lung metastasis in osteosarcoma.EZH2 is increased in paediatric T-cell acute lymphoblastic leukemia and is a suitable molecular target in combination treatment approachesTruncated DNMT3B isoform DNMT3B7 suppresses growth, induces differentiation, and alters DNA methylation in human neuroblastoma.Pediatric cancer epigenome and the influence of folateTranscription factor Yin-Yang 2 alters neuronal outgrowth in vitro.Shared Copy Number Variation in Simultaneous Nephroblastoma and Neuroblastoma due to Fanconi AnemiaPoorly differentiated synovial sarcoma is associated with high expression of enhancer of zeste homologue 2 (EZH2)NBAT1 suppresses breast cancer metastasis by regulating DKK1 via PRC2.MYCN and the epigenomeQuantitative Histone Mass Spectrometry Identifies Elevated Histone H3 Lysine 27 (Lys27) Trimethylation in Melanoma.Histone-lysine methyltransferase EHMT2 is involved in proliferation, apoptosis, cell invasion, and DNA methylation of human neuroblastoma cellsEpigenetic changes in pediatric solid tumors: promising new targets.CASZ1 inhibits cell cycle progression in neuroblastoma by restoring pRb activityIdentification of CASZ1 NES reveals potential mechanisms for loss of CASZ1 tumor suppressor activity in neuroblastoma.Dihydropyrimidinase-like protein 3 expression is negatively regulated by MYCN and associated with clinical outcome in neuroblastomaPhase I trial of a new schedule of romidepsin in patients with advanced cancers.MYCN and HDAC5 transcriptionally repress CD9 to trigger invasion and metastasis in neuroblastoma.EZH2 overexpression is associated with poor prognosis in patients with gliomaThe role of genetic and epigenetic alterations in neuroblastoma disease pathogenesis.Polycomb group proteins--epigenetic repressors with emerging roles in melanocytes and melanoma.Loss of RUNX3 expression is an independent adverse prognostic factor in diffuse large B-cell lymphoma.An allosteric PRC2 inhibitor targeting the H3K27me3 binding pocket of EED.Multimodal Regulation Orchestrates Normal and Complex Disease States in the RetinaEffects of Novel ncRNA Molecules, p15-piRNAs, on the Methylation of DNA and Histone H3 of the CDKN2B Promoter Region in U937 Cells.Lysine-specific demethylase (LSD1/KDM1A) and MYCN cooperatively repress tumor suppressor genes in neuroblastoma.H3K27 Methylation: A Focal Point of Epigenetic Deregulation in Cancer.Protein arginine methyltransferase 5 is a key regulator of the MYCN oncoprotein in neuroblastoma cells.Clusterin as a therapeutic target.
P2860
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P2860
EZH2 Mediates epigenetic silencing of neuroblastoma suppressor genes CASZ1, CLU, RUNX3, and NGFR
description
2011 nî lūn-bûn
@nan
2011年の論文
@ja
2011年学术文章
@wuu
2011年学术文章
@zh-cn
2011年学术文章
@zh-hans
2011年学术文章
@zh-my
2011年学术文章
@zh-sg
2011年學術文章
@yue
2011年學術文章
@zh
2011年學術文章
@zh-hant
name
EZH2 Mediates epigenetic silen ...... es CASZ1, CLU, RUNX3, and NGFR
@ast
EZH2 Mediates epigenetic silen ...... es CASZ1, CLU, RUNX3, and NGFR
@en
type
label
EZH2 Mediates epigenetic silen ...... es CASZ1, CLU, RUNX3, and NGFR
@ast
EZH2 Mediates epigenetic silen ...... es CASZ1, CLU, RUNX3, and NGFR
@en
prefLabel
EZH2 Mediates epigenetic silen ...... es CASZ1, CLU, RUNX3, and NGFR
@ast
EZH2 Mediates epigenetic silen ...... es CASZ1, CLU, RUNX3, and NGFR
@en
P2093
P2860
P1433
P1476
EZH2 Mediates epigenetic silen ...... es CASZ1, CLU, RUNX3, and NGFR
@en
P2093
Carol J Thiele
Chan-Wook Woo
Chunxi Wang
Javed Khan
Lifeng Wang
Qihuang Jin
Susan E Bates
Victor E Marquez
Zhihui Liu
P2860
P304
P356
10.1158/0008-5472.CAN-11-0961
P407
P50
P577
2011-11-08T00:00:00Z