A Critical Kinase Cascade in Neurological Disorders: PI 3-K, Akt, and mTOR. - Test2 - elhamkhani - TriplyDB

A Critical Kinase Cascade in Neurological Disorders: PI 3-K, Akt, and mTOR.

A Critical Kinase Cascade in Neurological Disorders: PI 3-K, Akt, and mTOR.

http://www.wikidata.org/entity/Q36379761

about

Novel nervous and multi-system regenerative therapeutic strategies for diabetes mellitus with mTOR Erythropoietin and diabetes mellitus Cutting through the complexities of mTOR for the treatment of stroke Erythropoietin and mTOR: A "One-Two Punch" for Aging-Related Disorders Accompanied by Enhanced Life Expectancy β-Hydroxy-β-Methylbutyrate (HMB) Promotes Neurite Outgrowth in Neuro2a Cells Autophagy: a double-edged sword for neuronal survival after cerebral ischemia Bipolar disorder with comorbid binge eating history: a genome-wide association study implicates APOB.Regeneration in the nervous system with erythropoietin Asarone from Acori Tatarinowii Rhizome prevents oxidative stress-induced cell injury in cultured astrocytes: A signaling triggered by Akt activation.Tuberous sclerosis protein 2 (TSC2) modulates CCN4 cytoprotection during apoptotic amyloid toxicity in microglia.Rapamycin, Autophagy, and Alzheimer's Disease mTOR, a Potential Target to Treat Autism Spectrum Disorder.A large scale Huntingtin protein interaction network implicates Rho GTPase signaling pathways in Huntington disease.Rapamycin modulated brain-derived neurotrophic factor and B-cell lymphoma 2 to mitigate autism spectrum disorder in rats.Targeting erythropoietin for chronic neurodegenerative diseases.Programming apoptosis and autophagy with novel approaches for diabetes mellitus.Activation of mTOR: a culprit of Alzheimer's disease?Targeting molecules to medicine with mTOR, autophagy and neurodegenerative disorders.Management of glaucoma as a neurodegenerative disease.Gene Manipulation Strategies to Identify Molecular Regulators of Axon Regeneration in the Central Nervous System.Comparative analysis of autophagy and tauopathy related markers in cerebral ischemia and Alzheimer's disease animal models.Hyperactivation of BDNF-TrkB signaling cascades in human hypothalamic hamartoma (HH): a potential mechanism contributing to epileptogenesis.Mechanism underlying the effects of doxepin on β-amyloid -induced memory impairment in rats.Cordyceps militaris improves the survival of Dahl salt-sensitive hypertensive rats possibly via influences of mitochondria and autophagy functions.Kinase-targeted cancer therapies: progress, challenges and future directions.PI3K pathway and Bcl-2 family. Clinicopathological features in prostate cancer.

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A Critical Kinase Cascade in Neurological Disorders: PI 3-K, Akt, and mTOR.

http://www.wikidata.org/entity/Q36379761

description

2012 nî lūn-bûn

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2012年の論文

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2012年学术文章

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2012年学术文章

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2012年学术文章

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2012年学术文章

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2012年学术文章

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2012年學術文章

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2012年學術文章

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2012年學術文章

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name

A Critical Kinase Cascade in Neurological Disorders: PI 3-K, Akt, and mTOR.

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A Critical Kinase Cascade in Neurological Disorders: PI 3-K, Akt, and mTOR.

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type

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A Critical Kinase Cascade in Neurological Disorders: PI 3-K, Akt, and mTOR.

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A Critical Kinase Cascade in Neurological Disorders: PI 3-K, Akt, and mTOR.

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A Critical Kinase Cascade in Neurological Disorders: PI 3-K, Akt, and mTOR.

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A Critical Kinase Cascade in Neurological Disorders: PI 3-K, Akt, and mTOR.

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Future Neurology

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A Critical Kinase Cascade in Neurological Disorders: PI 3-K, Akt, and mTOR.

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P2093

Kenneth Maiese

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Shaohui Wang

http://www.w3.org/2001/XMLSchema#string

Yan Chen Shang

http://www.w3.org/2001/XMLSchema#string

Zhao Zhong Chong

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P2860

Inhibition of mTOR by rapamycin abolishes cognitive deficits and reduces amyloid-beta levels in a mouse model of Alzheimer's disease

Rictor, a novel binding partner of mTOR, defines a rapamycin-insensitive and raptor-independent pathway that regulates the cytoskeleton

PRAS40 is an insulin-regulated inhibitor of the mTORC1 protein kinase

mTOR controls cell cycle progression through its cell growth effectors S6K1 and 4E-BP1/eukaryotic translation initiation factor 4E

Mammalian TOR complex 2 controls the actin cytoskeleton and is rapamycin insensitive

P-Rex1 links mammalian target of rapamycin signaling to Rac activation and cell migration

DEPTOR is an mTOR inhibitor frequently overexpressed in multiple myeloma cells and required for their survival

Two TOR complexes, only one of which is rapamycin sensitive, have distinct roles in cell growth control

Activity of TSC2 is inhibited by AKT-mediated phosphorylation and membrane partitioning

mTOR complex 2 (mTORC2) controls hydrophobic motif phosphorylation and activation of serum- and glucocorticoid-induced protein kinase 1 (SGK1)

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733-748

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10.2217/FNL.12.72

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6

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7

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3491909

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