Hydrogen peroxide scavenging rescues frataxin deficiency in a Drosophila model of Friedreich's ataxia.
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Towards a unifying, systems biology understanding of large-scale cellular death and destruction caused by poorly liganded iron: Parkinson's, Huntington's, Alzheimer's, prions, bactericides, chemical toxicology and others as examplesIron-dependent regulation of frataxin expression: implications for treatment of Friedreich ataxiaFriedreich's Ataxia: A Neuronal Point of View on the Oxidative Stress HypothesisTumor Suppressor WWOX Contributes to the Elimination of Tumorigenic Cells in Drosophila melanogasterRedox regulation of mitochondrial functionIron behaving badly: inappropriate iron chelation as a major contributor to the aetiology of vascular and other progressive inflammatory and degenerative diseasesImpaired nuclear Nrf2 translocation undermines the oxidative stress response in Friedreich ataxiaThe first cellular models based on frataxin missense mutations that reproduce spontaneously the defects associated with Friedreich ataxiaOverexpression of human and fly frataxins in Drosophila provokes deleterious effects at biochemical, physiological and developmental levelsIron testes: sperm mitochondria as a context for dissecting iron metabolism.Drosophila melanogaster in the study of human neurodegeneration.Mesenchymal stem cells restore frataxin expression and increase hydrogen peroxide scavenging enzymes in Friedreich ataxia fibroblastsFriedreich ataxia: molecular mechanisms, redox considerations, and therapeutic opportunities.Potential therapeutic benefits of strategies directed to mitochondria.Defects in mitochondrial axonal transport and membrane potential without increased reactive oxygen species production in a Drosophila model of Friedreich ataxiaThe optic nerve: a "mito-window" on mitochondrial neurodegenerationLoss of Frataxin induces iron toxicity, sphingolipid synthesis, and Pdk1/Mef2 activation, leading to neurodegeneration.Iron-sulfur cluster biogenesis and human diseaseFlightless flies: Drosophila models of neuromuscular disease.Ferritin overexpression in Drosophila glia leads to iron deposition in the optic lobes and late-onset behavioral defects.Reduction of mitochondrial H2O2 by overexpressing peroxiredoxin 3 improves glucose tolerance in miceTORC1 Inhibition by Rapamycin Promotes Antioxidant Defences in a Drosophila Model of Friedreich's AtaxiaA Yeast/Drosophila Screen to Identify New Compounds Overcoming Frataxin DeficiencyHepatic Deficiency of Augmenter of Liver Regeneration Exacerbates Alcohol-Induced Liver Injury and Promotes Fibrosis in Mice.Metal Homeostasis Regulators Suppress FRDA Phenotypes in a Drosophila Model of the DiseaseRedox processes in neurodegenerative disease involving reactive oxygen speciesIron-sulfur cluster synthesis, iron homeostasis and oxidative stress in Friedreich ataxia.Iron binding activity is essential for the function of IscA in iron-sulphur cluster biogenesisInsertion mutants in Drosophila melanogaster Hsc20 halt larval growth and lead to reduced iron-sulfur cluster enzyme activities and impaired iron homeostasis.Iron absorption in Drosophila melanogasterNeurodegeneration in Friedreich's ataxia: from defective frataxin to oxidative stressDrosophila frataxin: an iron chaperone during cellular Fe-S cluster bioassembly.Lateral-flow immunoassay for the frataxin protein in Friedreich's ataxia patients and carriers.JNK/FOXO-mediated neuronal expression of fly homologue of peroxiredoxin II reduces oxidative stress and extends life span.What can Drosophila teach us about iron-accumulation neurodegenerative disorders?Diabetes in Friedreich ataxia.Frataxin inactivation leads to steroid deficiency in flies and human ovarian cells.Unveiling a common mechanism of apoptosis in β-cells and neurons in Friedreich's ataxia.Frataxin deficiency leads to reduced expression and impaired translocation of NF-E2-related factor (Nrf2) in cultured motor neuronsMesenchymal Stem Cell-Derived Factors Restore Function to Human Frataxin-Deficient Cells.
P2860
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P2860
Hydrogen peroxide scavenging rescues frataxin deficiency in a Drosophila model of Friedreich's ataxia.
description
2008 nî lūn-bûn
@nan
2008年の論文
@ja
2008年学术文章
@wuu
2008年学术文章
@zh-cn
2008年学术文章
@zh-hans
2008年学术文章
@zh-my
2008年学术文章
@zh-sg
2008年學術文章
@yue
2008年學術文章
@zh
2008年學術文章
@zh-hant
name
Hydrogen peroxide scavenging r ...... model of Friedreich's ataxia.
@ast
Hydrogen peroxide scavenging r ...... model of Friedreich's ataxia.
@en
type
label
Hydrogen peroxide scavenging r ...... model of Friedreich's ataxia.
@ast
Hydrogen peroxide scavenging r ...... model of Friedreich's ataxia.
@en
prefLabel
Hydrogen peroxide scavenging r ...... model of Friedreich's ataxia.
@ast
Hydrogen peroxide scavenging r ...... model of Friedreich's ataxia.
@en
P2093
P2860
P356
P1476
Hydrogen peroxide scavenging r ...... model of Friedreich's ataxia.
@en
P2093
Arthur J Hilliker
John P Phillips
Peter R Anderson
William C Orr
P2860
P304
P356
10.1073/PNAS.0709691105
P407
P577
2008-01-09T00:00:00Z