Yeast frataxin sequentially chaperones and stores iron by coupling protein assembly with iron oxidation.
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Frataxin-mediated iron delivery to ferrochelatase in the final step of heme biosynthesisSalmonella enterica strains lacking the frataxin homolog CyaY show defects in Fe-S cluster metabolism in vivo.Chelatases: distort to select?Understanding the binding properties of an unusual metal-binding protein--a study of bacterial frataxinOligomerization Propensity and Flexibility of Yeast Frataxin Studied by X-ray Crystallography and Small-Angle X-ray ScatteringThe Molecular Basis of Iron-induced Oligomerization of Frataxin and the Role of the Ferroxidation Reaction in OligomerizationMonomeric yeast frataxin is an iron-binding protein.The iron metallome in eukaryotic organismsOverexpression of human and fly frataxins in Drosophila provokes deleterious effects at biochemical, physiological and developmental levelsIn silico pathway reconstruction: Iron-sulfur cluster biogenesis in Saccharomyces cerevisiae.PGC-1alpha down-regulation affects the antioxidant response in Friedreich's ataxia.Mitochondrial dysfunction induced by frataxin deficiency is associated with cellular senescence and abnormal calcium metabolismYeast frataxin solution structure, iron binding, and ferrochelatase interaction.The structure and function of frataxin.Human frataxin: iron and ferrochelatase binding surface.Friedreich ataxia: molecular mechanisms, redox considerations, and therapeutic opportunities.Intracellular iron transport and storage: from molecular mechanisms to health implications.Iron-induced oligomerization of yeast frataxin homologue Yfh1 is dispensable in vivoIron-sulfur cluster biosynthesis: characterization of Escherichia coli CYaY as an iron donor for the assembly of [2Fe-2S] clusters in the scaffold IscU.Metal ion substrate inhibition of ferrochelatase.Molecular insights into frataxin-mediated iron supply for heme biosynthesis in Bacillus subtilisFrataxin, iron-sulfur clusters, heme, ROS, and aging.Frataxin Is Localized to Both the Chloroplast and Mitochondrion and Is Involved in Chloroplast Fe-S Protein Function in ArabidopsisThe Structure of the Complex between Yeast Frataxin and Ferrochelatase: CHARACTERIZATION AND PRE-STEADY STATE REACTION OF FERROUS IRON DELIVERY AND HEME SYNTHESIS.Hydrogen peroxide scavenging rescues frataxin deficiency in a Drosophila model of Friedreich's ataxia.Iron-sulfur cluster synthesis, iron homeostasis and oxidative stress in Friedreich ataxia.Advancements in the pathophysiology of Friedreich's Ataxia and new prospects for treatments.Architecture of the Yeast Mitochondrial Iron-Sulfur Cluster Assembly Machinery: THE SUB-COMPLEX FORMED BY THE IRON DONOR, Yfh1 PROTEIN, AND THE SCAFFOLD, Isu1 PROTEIN.Drosophila frataxin: an iron chaperone during cellular Fe-S cluster bioassembly.Oligomeric yeast frataxin drives assembly of core machinery for mitochondrial iron-sulfur cluster synthesisThe power of yeast to model diseases of the powerhouse of the cell.Brain iron homeostasis: from molecular mechanisms to clinical significance and therapeutic opportunitiesFixing frataxin: 'ironing out' the metabolic defect in Friedreich's ataxiaExploring frataxin function.Frataxin: a protein in search for a function.Frataxin overexpressing mice.Architecture of the Human Mitochondrial Iron-Sulfur Cluster Assembly MachineryFrataxin knockdown causes loss of cytoplasmic iron-sulfur cluster functions, redox alterations and induction of heme transcripts.Structural basis of the iron storage function of frataxin from single-particle reconstruction of the iron-loaded oligomer.Conformational stability of human frataxin and effect of Friedreich's ataxia-related mutations on protein folding.
P2860
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P2860
Yeast frataxin sequentially chaperones and stores iron by coupling protein assembly with iron oxidation.
description
2003 nî lūn-bûn
@nan
2003 թուականի Օգոստոսին հրատարակուած գիտական յօդուած
@hyw
2003 թվականի օգոստոսին հրատարակված գիտական հոդված
@hy
2003年の論文
@ja
2003年論文
@yue
2003年論文
@zh-hant
2003年論文
@zh-hk
2003年論文
@zh-mo
2003年論文
@zh-tw
2003年论文
@wuu
name
Yeast frataxin sequentially ch ...... assembly with iron oxidation.
@ast
Yeast frataxin sequentially ch ...... assembly with iron oxidation.
@en
Yeast frataxin sequentially ch ...... assembly with iron oxidation.
@nl
type
label
Yeast frataxin sequentially ch ...... assembly with iron oxidation.
@ast
Yeast frataxin sequentially ch ...... assembly with iron oxidation.
@en
Yeast frataxin sequentially ch ...... assembly with iron oxidation.
@nl
altLabel
Yeast frataxin sequentially ch ...... n assembly with iron oxidation
@en
prefLabel
Yeast frataxin sequentially ch ...... assembly with iron oxidation.
@ast
Yeast frataxin sequentially ch ...... assembly with iron oxidation.
@en
Yeast frataxin sequentially ch ...... assembly with iron oxidation.
@nl
P2093
P2860
P356
P1476
Yeast frataxin sequentially ch ...... assembly with iron oxidation.
@en
P2093
Arianna Mangravita
Gloria C Ferreira
Grazia Isaya
Heather A O'Neill
Helen Nichol
Oleksandr Gakh
Sungjo Park
P2860
P304
P356
10.1074/JBC.M303158200
P407
P577
2003-08-15T00:00:00Z