ERG and FLI1 binding sites demarcate targets for aberrant epigenetic regulation by AML1-ETO in acute myeloid leukemia
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Potential Gene Interactions in the Cell Cycles of Gametes, Zygotes, Embryonic Stem Cells and the Development of CancerInterplay between Transcription Factors and the Epigenome: Insight from the Role of RUNX1 in LeukemiaTranscriptional network control of normal and leukaemic haematopoiesisA stable transcription factor complex nucleated by oligomeric AML1–ETO controls leukaemogenesisStructural and dynamic studies of the transcription factor ERG reveal DNA binding is allosterically autoinhibitedASXL2 is essential for haematopoiesis and acts as a haploinsufficient tumour suppressor in leukemia.RUNX1-ETO and RUNX1-EVI1 Differentially Reprogram the Chromatin Landscape in t(8;21) and t(3;21) AML.Cooperation between RUNX1-ETO9a and novel transcriptional partner KLF6 in upregulation of Alox5 in acute myeloid leukemia.Flow-induced protein kinase A-CREB pathway acts via BMP signaling to promote HSC emergence.Loss of TET2 in hematopoietic cells leads to DNA hypermethylation of active enhancers and induction of leukemogenesis.Genome-wide co-occupancy of AML1-ETO and N-CoR defines the t(8;21) AML signature in leukemic cells.Identification of a dynamic core transcriptional network in t(8;21) AML that regulates differentiation block and self-renewal.Genome Wide Mapping of NR4A Binding Reveals Cooperativity with ETS Factors to Promote Epigenetic Activation of Distal Enhancers in Acute Myeloid Leukemia CellsJMJD1C is required for the survival of acute myeloid leukemia by functioning as a coactivator for key transcription factors.Differential involvement of E2A-corepressor interactions in distinct leukemogenic pathways.BloodChIP: a database of comparative genome-wide transcription factor binding profiles in human blood cells.New insights into transcriptional and leukemogenic mechanisms of AML1-ETO and E2A fusion proteins.Aberrant epigenetic regulators control expansion of human CD34+ hematopoietic stem/progenitor cells.The ets transcription factor Fli-1 in development, cancer and disease.Pontin is a critical regulator for AML1-ETO-induced leukemia.The RUNX1-PU.1 axis in the control of hematopoiesis.Immune evasion by oncogenic proteins of acute myeloid leukemia.The oncofusion protein FUS-ERG targets key hematopoietic regulators and modulates the all-trans retinoic acid signaling pathway in t(16;21) acute myeloid leukemia.Runx1 Structure and Function in Blood Cell Development.MLL-AF9 and MLL-AF4 oncofusion proteins bind a distinct enhancer repertoire and target the RUNX1 program in 11q23 acute myeloid leukemia.AML associated oncofusion proteins PML-RARA, AML1-ETO and CBFB-MYH11 target RUNX/ETS-factor binding sites to modulate H3ac levels and drive leukemogenesis.Chronic FLT3-ITD Signaling in Acute Myeloid Leukemia Is Connected to a Specific Chromatin Signature.Major transcriptional changes observed in the Fulani, an ethnic group less susceptible to malaria.CBFB-MYH11/RUNX1 together with a compendium of hematopoietic regulators, chromatin modifiers and basal transcription factors occupies self-renewal genes in inv(16) acute myeloid leukemia.Developmental-stage-dependent transcriptional response to leukaemic oncogene expression.LMO2 (LIM domain only 2) is expressed in a subset of acute myeloid leukaemia and correlates with normal karyotype.Heterodimerization of AML1/ETO with CBFβ is required for leukemogenesis but not for myeloproliferation.Distinct mechanisms of regulation of the ITGA6 and ITGB4 genes by RUNX1 in myeloid cells.A FOXO1-induced oncogenic network defines the AML1-ETO preleukemic program.RUNX1-ETO Leukemia.The t(8;21) fusion protein RUNX1-ETO downregulates PKM2 in acute myeloid leukemia cells.Methylation-associated silencing of BASP1 contributes to leukemogenesis in t(8;21) acute myeloid leukemia.GFI1 is required for RUNX1/ETO positive acute myeloid leukemia.Cancer epigenetics: Moving forward.The oncogenic fusion protein CBFB-SMMHC downregulates CD48 to evade NK cell recognition.
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P2860
ERG and FLI1 binding sites demarcate targets for aberrant epigenetic regulation by AML1-ETO in acute myeloid leukemia
description
2012 nî lūn-bûn
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2012年の論文
@ja
2012年学术文章
@wuu
2012年学术文章
@zh-cn
2012年学术文章
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2012年学术文章
@zh-my
2012年学术文章
@zh-sg
2012年學術文章
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2012年學術文章
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2012年學術文章
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name
ERG and FLI1 binding sites dem ...... -ETO in acute myeloid leukemia
@ast
ERG and FLI1 binding sites dem ...... -ETO in acute myeloid leukemia
@en
type
label
ERG and FLI1 binding sites dem ...... -ETO in acute myeloid leukemia
@ast
ERG and FLI1 binding sites dem ...... -ETO in acute myeloid leukemia
@en
prefLabel
ERG and FLI1 binding sites dem ...... -ETO in acute myeloid leukemia
@ast
ERG and FLI1 binding sites dem ...... -ETO in acute myeloid leukemia
@en
P2093
P2860
P1433
P1476
ERG and FLI1 binding sites dem ...... -ETO in acute myeloid leukemia
@en
P2093
Abhishek A Singh
Amit Mandoli
Bart-Jan Wierenga
Edo Vellenga
Femke Simmer
Hendrik G Stunnenberg
Joost H A Martens
Sadia Saeed
P2860
P304
P356
10.1182/BLOOD-2012-05-429050
P407
P577
2012-09-14T00:00:00Z