On the structural basis for size-selective permeation of organic cations through the voltage-gated sodium channel. Effect of alanine mutations at the DEKA locus on selectivity, inhibition by Ca2+ and H+, and molecular sieving
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Overview of the voltage-gated sodium channel familyStructural and functional similarities of calcium homeostasis modulator 1 (CALHM1) ion channel with connexins, pannexins, and innexinsSpecific neosaxitoxin interactions with the Na+ channel outer vestibule determined by mutant cycle analysis.Permeability properties of ENaC selectivity filter mutantsThe hitchhiker's guide to the voltage-gated sodium channel galaxyTheoretical and simulation studies on voltage-gated sodium channelsInteracting ions in biophysics: real is not idealCytoplasmic polyamines as permeant blockers and modulators of the voltage-gated sodium channel.A molecular switch between the outer and the inner vestibules of the voltage-gated Na+ channelTwo sets of amino acids of the domain I of Cav2.3 Ca(2+) channels contribute to their high sensitivity to extracellular protonsThe VGL-Chanome: A Protein Superfamily Specialized for Electrical Signaling and Ionic HomeostasisExploring the structure of the voltage-gated Na+ channel by an engineered drug access pathway to the receptor site for local anesthetics.Constraint shapes convergence in tetrodotoxin-resistant sodium channels of snakesEnergetic localization of saxitoxin in its channel binding site.Ultra-slow inactivation in mu1 Na+ channels is produced by a structural rearrangement of the outer vestibuleAnalysis of the selectivity filter of the voltage-gated sodium channel Na(v)RhThe voltage-gated sodium channel TPC1 confers endolysosomal excitability.Inherited and acquired vulnerability to ventricular arrhythmias: cardiac Na+ and K+ channels.P-loop residues critical for selectivity in K channels fail to confer selectivity to rabbit HCN4 channels.Cardiac Na Channels: Structure to FunctionStructure-based assessment of disease-related mutations in human voltage-gated sodium channels.Voltage control of Ca²⁺ permeation through N-type calcium (Ca(V)2.2) channels.Differences in saxitoxin and tetrodotoxin binding revealed by mutagenesis of the Na+ channel outer vestibule.Molecular determinants of anion selectivity in the cystic fibrosis transmembrane conductance regulator chloride channel pore.Interactions of the C-11 hydroxyl of tetrodotoxin with the sodium channel outer vestibuleIonic selectivity and thermal adaptations within the voltage-gated sodium channel family of alkaliphilic Bacillus.Bacterial voltage-gated sodium channels (BacNa(V)s) from the soil, sea, and salt lakes enlighten molecular mechanisms of electrical signaling and pharmacology in the brain and heart.Ca2+ selectivity of a chemically modified OmpF with reduced pore volume.Current and selectivity in a model sodium channel under physiological conditions: Dynamic Monte Carlo simulations.Mechanism of Ion Permeation in Mammalian Voltage-Gated Sodium Channels.Steric selectivity in Na channels arising from protein polarization and mobile side chains.Calcium block of single sodium channels: role of a pore-lining aromatic residuePermeation properties of the hair cell mechanotransducer channel provide insight into its molecular structureSensitivity of cloned muscle, heart and neuronal voltage-gated sodium channels to block by polyamines: a possible basis for modulation of excitability in vivo.Lysine and the Na+/K+ Selectivity in Mammalian Voltage-Gated Sodium Channels.Speeding the recovery from ultraslow inactivation of voltage-gated Na+ channels by metal ion binding to the selectivity filter: a foot-on-the-door?Use-dependent block of the voltage-gated Na(+) channel by tetrodotoxin and saxitoxin: effect of pore mutations that change ionic selectivity.Block of tetrodotoxin-resistant Na+ channel pore by multivalent cations: gating modification and Na+ flow dependence.Permeation of large tetra-alkylammonium cations through mutant and wild-type voltage-gated sodium channels as revealed by relief of block at high voltageFunctional role and affinity of inorganic cations in stabilizing the tetrameric structure of the KcsA K+ channel
P2860
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P2860
On the structural basis for size-selective permeation of organic cations through the voltage-gated sodium channel. Effect of alanine mutations at the DEKA locus on selectivity, inhibition by Ca2+ and H+, and molecular sieving
description
1997 nî lūn-bûn
@nan
1997年の論文
@ja
1997年学术文章
@wuu
1997年学术文章
@zh-cn
1997年学术文章
@zh-hans
1997年学术文章
@zh-my
1997年学术文章
@zh-sg
1997年學術文章
@yue
1997年學術文章
@zh
1997年學術文章
@zh-hant
name
On the structural basis for si ...... and H+, and molecular sieving
@ast
On the structural basis for si ...... and H+, and molecular sieving
@en
type
label
On the structural basis for si ...... and H+, and molecular sieving
@ast
On the structural basis for si ...... and H+, and molecular sieving
@en
prefLabel
On the structural basis for si ...... and H+, and molecular sieving
@ast
On the structural basis for si ...... and H+, and molecular sieving
@en
P2093
P2860
P356
P1476
On the structural basis for si ...... and H+, and molecular sieving
@en
P2093
P2860
P304
P356
10.1085/JGP.110.6.693
P577
1997-12-01T00:00:00Z