MCT1-mediated transport of a toxic molecule is an effective strategy for targeting glycolytic tumors. - Test2 - elhamkhani - TriplyDB

MCT1-mediated transport of a toxic molecule is an effective strategy for targeting glycolytic tumors.

MCT1-mediated transport of a toxic molecule is an effective strategy for targeting glycolytic tumors.

http://www.wikidata.org/entity/Q36489907

about

How drugs get into cells: tested and testable predictions to help discriminate between transporter-mediated uptake and lipoidal bilayer diffusion Novel drugs that target the metabolic reprogramming in renal cell cancer Lactate Contribution to the Tumor Microenvironment: Mechanisms, Effects on Immune Cells and Therapeutic Relevance Starved and Asphyxiated: How Can CD8(+) T Cells within a Tumor Microenvironment Prevent Tumor Progression Genome Editing Using Mammalian Haploid Cells Glutamine and cancer: cell biology, physiology, and clinical opportunities How does the metabolism of tumour cells differ from that of normal cells Genome wide functional genetics in haploid cells Heterogeneity of glycolysis in cancers and therapeutic opportunities.The HK2 Dependent "Warburg Effect" and Mitochondrial Oxidative Phosphorylation in Cancer: Targets for Effective Therapy with 3-Bromopyruvate Hunting Viral Receptors Using Haploid Cells Human Haploid Cell Genetics Reveals Roles for Lipid Metabolism Genes in Nonapoptotic Cell Death Haploid genetic screens identify an essential role for PLP2 in the downregulation of novel plasma membrane targets by viral E3 ubiquitin ligases Dynamic and influential interaction of cancer cells with normal epithelial cells in 3D culture.Functional toxicology: tools to advance the future of toxicity testing.Targeting MYC Dependence by Metabolic Inhibitors in Cancer Radiosynthesis and validation of (±)-[18F]-3-fluoro-2-hydroxypropionate ([18F]-FLac) as a PET tracer of lactate to monitor MCT1-dependent lactate uptake in tumors Inhibition of ATPIF1 ameliorates severe mitochondrial respiratory chain dysfunction in mammalian cells.Inhibition of glucose turnover by 3-bromopyruvate counteracts pancreatic cancer stem cell features and sensitizes cells to gemcitabine.Tumor bioenergetics: an emerging avenue for cancer metabolism targeted therapy The basal epithelial marker P-cadherin associates with breast cancer cell populations harboring a glycolytic and acid-resistant phenotype.Metabolic determinants of cancer cell sensitivity to glucose limitation and biguanides.Megabase-scale deletion using CRISPR/Cas9 to generate a fully haploid human cell line.3-bromopyruvate enhanced daunorubicin-induced cytotoxicity involved in monocarboxylate transporter 1 in breast cancer cells Tumor metabolism, cancer cell transporters, and microenvironmental resistance.The adaptor protein p66Shc inhibits mTOR-dependent anabolic metabolism.Systemic administration of 3-bromopyruvate reveals its interaction with serum proteins in a rat model.Catabolism of exogenous lactate reveals it as a legitimate metabolic substrate in breast cancer.Metabolic regulation of cancer cell side population by glucose through activation of the Akt pathway.The energy blocker inside the power house: Mitochondria targeted delivery of 3-bromopyruvate.Cancer metabolism: strategic diversion from targeting cancer drivers to targeting cancer suppliers Gene transfer and genome-wide insertional mutagenesis by retroviral transduction in fish stem cells.Molecular Pathways: Targeting Cellular Energy Metabolism in Cancer via Inhibition of SLC2A1 and LDHA Functional genomic screening approaches in mechanistic toxicology and potential future applications of CRISPR-Cas9.3-BrPA eliminates human bladder cancer cells with highly oncogenic signatures via engagement of specific death programs and perturbation of multiple signaling and metabolic determinants.Identification of Genes That Modulate Susceptibility to Formaldehyde and Imatinib by Functional Genomic Screening in Human Haploid KBM7 Cells.Hypoxic resistance of KRAS mutant tumor cells to 3-Bromopyruvate is counteracted by Prima-1 and reversed by N-acetylcysteine.Merkel Cell Polyomavirus Small T Antigen Promotes Pro-Glycolytic Metabolic Perturbations Required for Transformation.Primary clear cell renal carcinoma cells display minimal mitochondrial respiratory capacity resulting in pronounced sensitivity to glycolytic inhibition by 3-Bromopyruvate Targeting glucose metabolism in cancer: new class of agents for loco-regional and systemic therapy of liver cancer and beyond?

P2860

Q24273350-53797606-2A3E-4A6F-8F55-E2AB8E03F1FD Q26740187-09A7E372-EB36-4423-A204-AC3BCA1E8A1F Q26766711-9A417CD8-A23E-442F-B8E6-5212802B88E2 Q26767514-D4224DA2-C9CC-4744-8C2A-2FA72665AD90 Q26782077-89608241-5B39-4632-A045-F5B0C3BEAE79 Q27011818-AF3E9B23-5483-4B1C-912C-92FB2F85ACF5 Q27011856-C74A6EF5-C5C4-4A82-B3EB-83BC051C3D88 Q27015889-2F744854-EDAD-4136-A586-2B7013A45CED Q27693375-5D933EC0-77C3-457C-8868-F4ECC6419532 Q28073392-A3895291-399E-47CF-8558-91C823765BF5 Q28080327-7AE9E7CB-2A6C-4C98-BEEE-E49CA8A3E720 Q28261885-B93A35CF-AF36-4AC6-BC27-ACD1D8FEA2B4 Q28535346-5B58857C-8D2B-41E5-A495-135A30D0F5C2 Q30596963-6F65C50A-F587-4234-B67F-E11705318DD1 Q33595247-8CB38E36-5823-407D-BAD0-EC67EDCF8E26 Q33608493-EF86D6BC-E184-4748-A000-513F1212F0F1 Q33648519-FA9AD628-ED69-4A6F-AA62-65D6A78E66A5 Q33696265-371F8E55-3EE0-4024-8AB4-DF89F17905F1 Q34104182-209484A5-EE55-48D3-83EC-291A1234128B Q34179999-F697FF76-2161-4F7F-9C1D-C769F6C2B696 Q34309472-A07802CB-2496-4C82-ACAF-F0EB9E2C6216 Q34412152-2873EE56-EC5A-4438-814B-5D5A35F4FC3D Q34446440-AF2E2C11-CDE3-4BC9-AE9C-033D38ED1E0E Q34503166-9316B5CC-294D-48C6-98AB-87B19346BD65 Q34513382-7BA7EB59-9510-4719-97E8-7286962FDEA1 Q34663562-00A460B2-22F2-4279-A625-ED076BB7383B Q34834980-4FA529A8-55A6-4D7E-AF56-90256D6229CA Q34999491-F8D7057D-E98B-4FEE-AE46-E14506D57872 Q35008587-23A1EE4F-3EE9-4969-9FF3-306A693804AF Q35104357-3B7838D8-B577-4529-97B7-69418516B049 Q35161318-5F794F80-56CD-4F52-ADC0-A9B57DC38592 Q35647626-EC8449FB-4D70-42DC-B905-3E776814AA4C Q35674921-4FD3FCAB-4DA8-4041-AED2-8C3E61CE42BB Q35686057-5B709AF5-EC28-44A6-BB24-C624DE8B656E Q35879138-40EE5FDE-2E7E-473B-9890-551E4BFA6156 Q35968059-373384ED-D7C4-4A00-B412-0C23F6038CC6 Q36198159-42FA7E41-4E70-4ABA-9214-6D6D2DD47E50 Q36202583-3ED5356A-9E5F-4FF3-A580-8F4B215EDC5F Q36347081-A6CE8EBC-F181-40A4-AF9A-376E9A4F895E Q36687966-AF2AF208-2571-4706-93BE-0231B93E3DD3

P2860

MCT1-mediated transport of a toxic molecule is an effective strategy for targeting glycolytic tumors.

http://www.wikidata.org/entity/Q36489907

description

2012 nî lūn-bûn

@nan

2012年の論文

@ja

2012年学术文章

@wuu

2012年学术文章

@zh-cn

2012年学术文章

@zh-hans

2012年学术文章

@zh-my

2012年学术文章

@zh-sg

2012年學術文章

@yue

2012年學術文章

@zh

2012年學術文章

@zh-hant

name

MCT1-mediated transport of a t ...... r targeting glycolytic tumors.

@ast

MCT1-mediated transport of a t ...... r targeting glycolytic tumors.

@en

type

label

MCT1-mediated transport of a t ...... r targeting glycolytic tumors.

@ast

MCT1-mediated transport of a t ...... r targeting glycolytic tumors.

@en

prefLabel

MCT1-mediated transport of a t ...... r targeting glycolytic tumors.

@ast

MCT1-mediated transport of a t ...... r targeting glycolytic tumors.

@en

P1433

Q36489907-8040E6E2-9026-41AA-ADE2-ECA452B1D67D

P1476

Q36489907-9FBF2790-7965-4075-9A44-090B638C926A

P2093

Q36489907-500DEB3F-E622-46BE-85FB-CB3358E42B25

Q36489907-537A1C18-780E-457F-8B1F-9F0E56228C40

Q36489907-782B250D-F85C-4F99-AECF-2FD45201926C

Q36489907-7FCDEA2E-F821-4F1A-8392-8B14C1521B71

Q36489907-8F174903-DF19-4F25-BDB7-E2F5B65D45F9

Q36489907-935F905F-AFE9-40C2-B6FD-DB5400874CAB

Q36489907-CEDEEC93-A684-40FB-8139-EEA89C6917A4

Q36489907-DA8C04E9-A81F-47D4-818E-604E31145AC1

Q36489907-F1EFEEAA-1CA4-46D8-A316-3D1FFC761B90

Q36489907-F9C00FAB-2E93-49D5-941A-7BA52F7BE445

P2860

Q36489907-02436C9C-C483-4C3F-AFF1-C2FD784D9425

Q36489907-13EBDE56-6DEA-43C9-8B95-C2C8CD917A60

Q36489907-200E4E0C-EF70-4B32-9BB0-85EB6DE315CE

Q36489907-2E8CDB38-5AD3-429A-8BEA-1075B22B1CBC

Q36489907-2E9E305A-884F-413C-B490-14A17630A174

Q36489907-329AA900-8436-49BB-ADB2-EDDC812121BB

Q36489907-3E0F0BED-A298-4713-9E89-E402E33302BD

Q36489907-4158D459-DA40-46F3-81FA-CFB4457C0F4C

Q36489907-421BB15C-77A6-4E6C-98B4-087AB90421C0

Q36489907-51E61453-9ADB-45B4-B31C-273B2D4C54D3

P2888

Q36489907-FFE7D98A-15B7-45A9-82EE-FB35123EF21A

P304

Q36489907-41F3BE0E-23A3-4EC5-9F15-97B4560C77B5

P31

Q36489907-94AE6F59-0780-41AA-9D2D-0EB383598CCE

P356

Q36489907-29FB56E3-A4EA-4EB7-B40A-2098E4E18ED3

P407

Q36489907-6DBDF7E8-C50B-41CA-A0FB-45B458B6E5BF

P433

Q36489907-CACBD23A-755E-4B6C-8D1C-3DF3F790B864

P478

Q36489907-94B977CD-38EC-40D3-AC95-8442A8C97664

P50

Q36489907-4EA8E267-C325-4D09-92C7-5489613E204D

Q36489907-7DA203AC-0314-4F9F-B50B-09C7D8DE1B80

Q36489907-C55F3F6F-1958-48B1-A70C-AAEBADC440B3

P577

Q36489907-5BF498AE-8DD5-4AA3-965B-F3AA1E31F0A0

P5875

Q36489907-1E92EE8C-C400-4EEB-A11B-55794D6DAFE9

P6179

Q36489907-96882885-D085-4E70-9A0D-029AD7504005

P698

Q36489907-F9D6FA29-D18F-4F19-AFE3-E092F5E4C638

P932

Q36489907-925886ED-E0CF-4068-8619-E2E0DBA47947

P356

P1433

Nature Genetics

P1476

MCT1-mediated transport of a t ...... r targeting glycolytic tumors.

@en

P2093

Amanda W Hutchins

http://www.w3.org/2001/XMLSchema#string

Catherine E Koch

http://www.w3.org/2001/XMLSchema#string

Clary B Clish

http://www.w3.org/2001/XMLSchema#string

David M Sabatini

http://www.w3.org/2001/XMLSchema#string

Kivanç Birsoy

http://www.w3.org/2001/XMLSchema#string

Omer H Yilmaz

http://www.w3.org/2001/XMLSchema#string

Thijn R Brummelkamp

http://www.w3.org/2001/XMLSchema#string

Tim R Peterson

http://www.w3.org/2001/XMLSchema#string

Tim Wang

http://www.w3.org/2001/XMLSchema#string

Yetis Gultekin

http://www.w3.org/2001/XMLSchema#string

P2860

Identification of small molecule inhibitors of pyruvate kinase M2

Ebola virus entry requires the cholesterol transporter Niemann-Pick C1

Haploid genetic screens in human cells identify host factors used by pathogens

The AMPK signalling pathway coordinates cell growth, autophagy and metabolism

CD147 is tightly associated with lactate transporters MCT1 and MCT4 and facilitates their cell surface expression

Upregulation of the amino acid transporter ATB0,+ (SLC6A14) in colorectal cancer and metastasis in humans

Glycolysis inhibition for anticancer treatment

A novel inhibitor of glucose uptake sensitizes cells to FAS-induced cell death

The Cancer Cell Line Encyclopedia enables predictive modelling of anticancer drug sensitivity

On respiratory impairment in cancer cells

P2888

P304

104-108

http://www.w3.org/2001/XMLSchema#string

P31

scholarly article

P356

10.1038/NG.2471

http://www.w3.org/2001/XMLSchema#string

P407

P433

1

http://www.w3.org/2001/XMLSchema#string

P478

45

http://www.w3.org/2001/XMLSchema#string

P50

Richard Possemato

P577

2012-12-02T00:00:00Z

http://www.w3.org/2001/XMLSchema#dateTime

P5875

233828441

http://www.w3.org/2001/XMLSchema#string

P6179

1053270214

http://www.w3.org/2001/XMLSchema#string

P698

23202129

http://www.w3.org/2001/XMLSchema#string

P932

3530647

http://www.w3.org/2001/XMLSchema#string