Metabolic determinants of cancer cell sensitivity to glucose limitation and biguanides. - Test2 - elhamkhani - TriplyDB

Metabolic determinants of cancer cell sensitivity to glucose limitation and biguanides.

Metabolic determinants of cancer cell sensitivity to glucose limitation and biguanides.

http://www.wikidata.org/entity/Q34412152

about

Repurposing metformin: an old drug with new tricks in its binding pockets Fundamentals of cancer metabolism Energy disruptors: rising stars in anticancer therapy?Treatment Strategies that Enhance the Efficacy and Selectivity of Mitochondria-Targeted Anticancer Agents Mechanistic target of rapamycin (mTOR): a point of convergence in the action of insulin/IGF-1 and G protein-coupled receptor agonists in pancreatic cancer cells A roadmap for interpreting (13)C metabolite labeling patterns from cells Redox control of glutamine utilization in cancer Macrophage proliferation, provenance, and plasticity in macroparasite infection Old drug, new trick: repurposing metformin for gynecologic cancers?Targeting mitochondria metabolism for cancer therapy Defects in mitochondrial metabolism and cancer Drugging the addict: non-oncogene addiction as a target for cancer therapy Metabolic pathways promoting cancer cell survival and growth Preventing Alzheimer's disease by means of natural selection Grainyhead-like 2 Reverses the Metabolic Changes Induced by the Oncogenic Epithelial-Mesenchymal Transition: Effects on Anoikis Metformin Antagonizes Cancer Cell Proliferation by Suppressing Mitochondrial-Dependent Biosynthesis Medium Renewal Blocks Anti-Proliferative Effects of Metformin in Cultured MDA-MB-231 Breast Cancer Cells Population Density Modulates Drug Inhibition and Gives Rise to Potential Bistability of Treatment Outcomes for Bacterial Infections MATE2 Expression Is Associated with Cancer Cell Response to Metformin Proteomic analysis of pRb loss highlights a signature of decreased mitochondrial oxidative phosphorylation Mitochondrial division is requisite to RAS-induced transformation and targeted by oncogenic MAPK pathway inhibitors.Therapeutic inhibition of mitochondrial function induces cell death in starvation-resistant renal cell carcinomas Selective Vulnerability of Cancer Cells by Inhibition of Ca(2+) Transfer from Endoplasmic Reticulum to Mitochondria ROS signaling under metabolic stress: cross-talk between AMPK and AKT pathway.Metformin inhibits mitochondrial complex I of cancer cells to reduce tumorigenesis Combined treatment with Metformin and 2-deoxy glucose induces detachment of viable MDA-MB-231 breast cancer cells in vitro.Flux balance analysis predicts essential genes in clear cell renal cell carcinoma metabolism.Anaplerotic metabolism of alloreactive T cells provides a metabolic approach to treat graft-versus-host disease.Attacking the supply wagons to starve cancer cells to death.Mitochondrial DNA somatic mutation in cancer Metformin repositioning as antitumoral agent: selective antiproliferative effects in human glioblastoma stem cells, via inhibition of CLIC1-mediated ion current Organization of enzyme concentration across the metabolic network in cancer cells Sorafenib synergizes with metformin in NSCLC through AMPK pathway activation.Different effects of LDH-A inhibition by oxamate in non-small cell lung cancer cells Famine versus feast: understanding the metabolism of tumors in vivo.Stable heteroplasmy at the single-cell level is facilitated by intercellular exchange of mtDNA.Estrogen receptor alpha drives proliferation in PTEN-deficient prostate carcinoma by stimulating survival signaling, MYC expression and altering glucose sensitivity The multikinase inhibitor Sorafenib enhances glycolysis and synergizes with glycolysis blockade for cancer cell killing.Mitophagy and cancer.Estimating relative changes of metabolic fluxes.

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Metabolic determinants of cancer cell sensitivity to glucose limitation and biguanides.

http://www.wikidata.org/entity/Q34412152

description

2014 nî lūn-bûn

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2014 թուականի Մարտին հրատարակուած գիտական յօդուած

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2014 թվականի մարտին հրատարակված գիտական հոդված

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2014年の論文

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2014年論文

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2014年論文

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2014年論文

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2014年論文

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2014年論文

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2014年论文

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name

Metabolic determinants of cancer cell sensitivity to glucose limitation and biguanides.

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Metabolic determinants of cancer cell sensitivity to glucose limitation and biguanides.

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Metabolic determinants of cancer cell sensitivity to glucose limitation and biguanides.

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Metabolic determinants of cancer cell sensitivity to glucose limitation and biguanides.

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Metabolic determinants of cancer cell sensitivity to glucose limitation and biguanides.

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Metabolic determinants of cancer cell sensitivity to glucose limitation and biguanides.

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Metabolic determinants of cancer cell sensitivity to glucose limitation and biguanides.

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Metabolic determinants of cancer cell sensitivity to glucose limitation and biguanides.

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Metabolic determinants of cancer cell sensitivity to glucose limitation and biguanides.

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Metabolic determinants of cancer cell sensitivity to glucose limitation and biguanides

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Burcu Yucel

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Erol C Bayraktar

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Kıvanç Birsoy

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Prathapan Thiru

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Regulation of cancer cell metabolism

Investigation of mitochondrial dysfunction by sequential microplate-based respiration measurements from intact and permeabilized neurons

Coupling of glucose deprivation with impaired histone H2B monoubiquitination in tumors

The Cancer Cell Line Encyclopedia enables predictive modelling of anticancer drug sensitivity

Evidence that metformin exerts its anti-diabetic effects through inhibition of complex 1 of the mitochondrial respiratory chain

Metformin and reduced risk of cancer in diabetic patients

Metformin and cancer risk in diabetic patients: a systematic review and meta-analysis.

Exome sequencing identifies ACAD9 mutations as a cause of complex I deficiency.

Functional genomics reveal that the serine synthesis pathway is essential in breast cancer

Dimethylbiguanide inhibits cell respiration via an indirect effect targeted on the respiratory chain complex I.

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10.1038/NATURE13110

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7494

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Richard Possemato

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261137891

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