mTOR: on target for novel therapeutic strategies in the nervous system. - Test2 - elhamkhani - TriplyDB

mTOR: on target for novel therapeutic strategies in the nervous system.

mTOR: on target for novel therapeutic strategies in the nervous system.

http://www.wikidata.org/entity/Q36501214

about

Anticancer strategies based on the metabolic profile of tumor cells: therapeutic targeting of the Warburg effect Novel nervous and multi-system regenerative therapeutic strategies for diabetes mellitus with mTOR Erythropoietin and diabetes mellitus Stem cell guidance through the mechanistic target of rapamycin Cutting through the complexities of mTOR for the treatment of stroke Driving neural regeneration through the mammalian target of rapamycin Erythropoietin and mTOR: A "One-Two Punch" for Aging-Related Disorders Accompanied by Enhanced Life Expectancy New Insights for Oxidative Stress and Diabetes Mellitus Novel applications of trophic factors, Wnt and WISP for neuronal repair and regeneration in metabolic disease WISP1: Clinical insights for a proliferative and restorative member of the CCN family Circadian dysregulation of clock genes: clues to rapid treatments in major depressive disorder.Neurobiochemical mechanisms of a ketogenic diet in refractory epilepsy Evidence for mTOR pathway activation in a spectrum of epilepsy-associated pathologies.Taking aim at Alzheimer's disease through the mammalian target of rapamycin REDD2 expression in rat skeletal muscle correlates with nutrient-induced activation of mTORC1: responses to aging, immobilization, and remobilization.mTOR regulates brain morphogenesis by mediating GSK3 signaling.Transcript and protein expression decoupling reveals RNA binding proteins and miRNAs as potential modulators of human aging.(R)-(+)-α-lipoic acid protected NG108-15 cells against H₂O₂-induced cell death through PI3K-Akt/GSK-3β pathway and suppression of NF-κβ-cytokines.A possible role for AMP-activated protein kinase activated by metformin and AICAR in human granulosa cells.FASTKD2 is associated with memory and hippocampal structure in older adults.Increased autophagy and apoptosis contribute to muscle atrophy in a myotonic dystrophy type 1 Drosophila model.Autophagy and ethanol neurotoxicity Regeneration in the nervous system with erythropoietin MicroRNAs 99b-5p/100-5p Regulated by Endoplasmic Reticulum Stress are Involved in Abeta-Induced Pathologies.A Novel Hsp90 Inhibitor Activates Compensatory Heat Shock Protein Responses and Autophagy and Alleviates Mutant A53T α-Synuclein Toxicity.Halofuginone inhibits colorectal cancer growth through suppression of Akt/mTORC1 signaling and glucose metabolism.Age-dependent changes in the protein expression levels of Redd1 and mTOR in the gerbil hippocampus during normal aging Forkhead transcription factors: new considerations for alzheimer's disease and dementia.Towards a 'systems'-level understanding of the nervous system and its disorders.4EBP-Dependent Signaling Supports West Nile Virus Growth and Protein Expression.Dry age-related macular degeneration: mechanisms, therapeutic targets, and imaging.Autophagy in Diabetic Retinopathy.Combination of Endothelial-Monocyte-Activating Polypeptide-II with Temozolomide Suppress Malignant Biological Behaviors of Human Glioblastoma Stem Cells via miR-590-3p/MACC1 Inhibiting PI3K/AKT/mTOR Signal Pathway.DDIT4/REDD1/RTP801 is a novel negative regulator of Schwann cell myelination.Temporal changes in mammalian target of rapamycin (mTOR) and phosphorylated-mTOR expressions in the hippocampal CA1 region of rat with vascular dementia.Translational research in endocrine surgery.Glutamate drugs and pharmacogenetics of OCD: a pathway-based exploratory approach.mTOR complex 1: a key player in neuroadaptations induced by drugs of abuse.Aberrant autophagy and parkinsonism: does correction rescue from disease progression?Prion degradation pathways: Potential for therapeutic intervention.

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mTOR: on target for novel therapeutic strategies in the nervous system.

http://www.wikidata.org/entity/Q36501214

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2012年论文

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2012年论文

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mTOR: on target for novel therapeutic strategies in the nervous system.

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mTOR: on target for novel therapeutic strategies in the nervous system.

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mTOR: on target for novel therapeutic strategies in the nervous system.

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mTOR: on target for novel therapeutic strategies in the nervous system.

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mTOR: on target for novel therapeutic strategies in the nervous system.

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mTOR: on target for novel therapeutic strategies in the nervous system.

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J.MOLMED.2012.11.001

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Trends in Molecular Medicine

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mTOR: on target for novel therapeutic strategies in the nervous system.

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Kenneth Maiese

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Shaohui Wang

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Yan Chen Shang

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Zhao Zhong Chong

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P2860

Inhibition of mTOR by rapamycin abolishes cognitive deficits and reduces amyloid-beta levels in a mouse model of Alzheimer's disease

Phosphorylation and regulation of Akt/PKB by the rictor-mTOR complex

Rictor, a novel binding partner of mTOR, defines a rapamycin-insensitive and raptor-independent pathway that regulates the cytoskeleton

P-Rex1 links mammalian target of rapamycin signaling to Rac activation and cell migration

DEPTOR is an mTOR inhibitor frequently overexpressed in multiple myeloma cells and required for their survival

Atg101, a novel mammalian autophagy protein interacting with Atg13

Activity of TSC2 is inhibited by AKT-mediated phosphorylation and membrane partitioning

Disruption of the mouse mTOR gene leads to early postimplantation lethality and prohibits embryonic stem cell development

mTOR is essential for growth and proliferation in early mouse embryos and embryonic stem cells

ULK-Atg13-FIP200 complexes mediate mTOR signaling to the autophagy machinery

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51-60

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10.1016/J.MOLMED.2012.11.001

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1

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3534789

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