Biological Characterization of an Improved Pyrrole-Based Colchicine Site Agent Identified through Structure-Based Design
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Janus Compounds, 5-Chloro-N⁴-methyl-N⁴-aryl-9H-pyrimido[4,5-b]indole-2,4-diamines, Cause Both Microtubule Depolymerizing and Stabilizing Effects.Ortho group activation of a bromopyrrole ester in Suzuki-Miyaura cross-coupling reactions: Application to the synthesis of new microtubule depolymerizing agents with potent cytotoxic activities.Design, Synthesis, and Preclinical Evaluation of 4-Substituted-5-methyl-furo[2,3-d]pyrimidines as Microtubule Targeting Agents That Are Effective against Multidrug Resistant Cancer Cells.Effects of a novel microtubule-depolymerizer on pro-inflammatory signaling in RAW264.7 macrophages.
P2860
Biological Characterization of an Improved Pyrrole-Based Colchicine Site Agent Identified through Structure-Based Design
description
2015 nî lūn-bûn
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2015年の論文
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2015年論文
@yue
2015年論文
@zh-hant
2015年論文
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2015年論文
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2015年論文
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2015年论文
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name
Biological Characterization of ...... through Structure-Based Design
@ast
Biological Characterization of ...... through Structure-Based Design
@en
type
label
Biological Characterization of ...... through Structure-Based Design
@ast
Biological Characterization of ...... through Structure-Based Design
@en
prefLabel
Biological Characterization of ...... through Structure-Based Design
@ast
Biological Characterization of ...... through Structure-Based Design
@en
P2093
P2860
P356
P1476
Biological Characterization of ...... through Structure-Based Design
@en
P2093
April L Risinger
Chenxiao Da
Cristina C Rohena
James A Sikorski
John T Gupton
Nakul S Telang
Susan L Mooberry
P2860
P304
P356
10.1124/MOL.115.101592
P577
2015-12-11T00:00:00Z