A systematic review of prion therapeutics in experimental models.
about
Continuous quinacrine treatment results in the formation of drug-resistant prionsTransmissible Spongiform Encephalopathies Affecting Humans2-Aminothiazoles as therapeutic leads for prion diseasesSafety and efficacy of quinacrine in human prion disease (PRION-1 study): a patient-preference trialLentivector-mediated RNAi efficiently suppresses prion protein and prolongs survival of scrapie-infected miceTreatment of Prion Disease with Heterologous Prion ProteinsCalcineurin inhibition at the clinical phase of prion disease reduces neurodegeneration, improves behavioral alterations and increases animal survivalAntihypertensive drug guanabenz is active in vivo against both yeast and mammalian prionsProtein folding activity of ribosomal RNA is a selective target of two unrelated antiprion drugsDiscovery of a novel, monocationic, small-molecule inhibitor of scrapie prion accumulation in cultured sheep microglia and Rov cellsAnti-prion activity of a panel of aromatic chemical compounds: in vitro and in silico approachesSuramin inhibits Hsp104 ATPase and disaggregase activityStyryl-based and tricyclic compounds as potential anti-prion agentsAnle138b: a novel oligomer modulator for disease-modifying therapy of neurodegenerative diseases such as prion and Parkinson's disease.A synergistic small-molecule combination directly eradicates diverse prion strain structuresFrom high-throughput cell culture screening to mouse model: identification of new inhibitor classes against prion disease.Genomic and post-genomic analyses of human prion diseasesHigh-b-value diffusion MR imaging and basal nuclei apparent diffusion coefficient measurements in variant and sporadic Creutzfeldt-Jakob disease.Discovery of 2-aminothiazoles as potent antiprion compounds.Efficacy of novel acridine derivatives in the inhibition of hPrP90-231 prion protein fragment toxicity.Chemical induction of misfolded prion protein conformers in cell culture.A highly toxic cellular prion protein induces a novel, nonapoptotic form of neuronal deathUnique drug screening approach for prion diseases identifies tacrolimus and astemizole as antiprion agentsSuccesses and challenges in phenotype-based lead discovery for prion diseasesVariant Creutzfeldt-Jakob disease with extremely low lymphoreticular deposition of prion protein.Therapeutic molecules and endogenous ligands regulate the interaction between brain cellular prion protein (PrPC) and metabotropic glutamate receptor 5 (mGluR5).Prions.Prion protein-specific antibodies-development, modes of action and therapeutics applicationReview: contribution of transgenic models to understanding human prion disease.Immunomodulation for prion and prion-related diseases.Experimental treatments for human transmissible spongiform encephalopathies: is there a role for pentosan polysulfate?Antiprion compounds that reduce PrP(Sc) levels in dividing and stationary-phase cells.A survey of antiprion compounds reveals the prevalence of non-PrP molecular targets.Establishment and characterization of Prnp knockdown neuroblastoma cells using dual microRNA-mediated RNA interferenceIdentification of chemoattractive factors involved in the migration of bone marrow-derived mesenchymal stem cells to brain lesions caused by prionsRapidly progressive dementias and the treatment of human prion diseases.Ion channels induced by the prion protein: mediators of neurotoxicity.Antiprion Activity of DB772 and Related Monothiophene- and Furan-Based Analogs in a Persistently Infected Ovine Microglia Culture SystemDiscovery of Novel Anti-prion Compounds Using In Silico and In Vitro ApproachesCell division modulates prion accumulation in cultured cells
P2860
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P2860
A systematic review of prion therapeutics in experimental models.
description
2006 nî lūn-bûn
@nan
2006年の論文
@ja
2006年論文
@yue
2006年論文
@zh-hant
2006年論文
@zh-hk
2006年論文
@zh-mo
2006年論文
@zh-tw
2006年论文
@wuu
2006年论文
@zh
2006年论文
@zh-cn
name
A systematic review of prion therapeutics in experimental models.
@ast
A systematic review of prion therapeutics in experimental models.
@en
type
label
A systematic review of prion therapeutics in experimental models.
@ast
A systematic review of prion therapeutics in experimental models.
@en
prefLabel
A systematic review of prion therapeutics in experimental models.
@ast
A systematic review of prion therapeutics in experimental models.
@en
P356
P1433
P1476
A systematic review of prion therapeutics in experimental models.
@en
P2093
Clare R Trevitt
John Collinge
P304
P356
10.1093/BRAIN/AWL150
P407
P577
2006-07-01T00:00:00Z