Cancer-associated SF3B1 mutations affect alternative splicing by promoting alternative branchpoint usage. - Test2 - elhamkhani - TriplyDB

Cancer-associated SF3B1 mutations affect alternative splicing by promoting alternative branchpoint usage.

Cancer-associated SF3B1 mutations affect alternative splicing by promoting alternative branchpoint usage.

http://www.wikidata.org/entity/Q36549378

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Modulating splicing with small molecular inhibitors of the spliceosome Spliceosomal gene mutations in myelodysplasia: molecular links to clonal abnormalities of hematopoiesis Emerging concepts of epigenetic dysregulation in hematological malignancies SF3b1 mutations associated with myelodysplastic syndromes alter the fidelity of branchsite selection in yeast How do messenger RNA splicing alterations drive myelodysplasia?Splicing factor SF3B1K700E mutant dysregulates erythroid differentiation via aberrant alternative splicing of transcription factor TAL1.Targeting Splicing in the Treatment of Myelodysplastic Syndromes and Other Myeloid Neoplasms.Jerantinine A induces tumor-specific cell death through modulation of splicing factor 3b subunit 1 (SF3B1)Lessons from non-canonical splicing Mutant U2AF1-expressing cells are sensitive to pharmacological modulation of the spliceosome.SF3B1/Hsh155 HEAT motif mutations affect interaction with the spliceosomal ATPase Prp5, resulting in altered branch site selectivity in pre-mRNA splicing Cancer-associated SF3B1 mutants recognize otherwise inaccessible cryptic 3' splice sites within RNA secondary structures.The biology of uveal melanoma Hemopoietic-specific Sf3b1-K700E knock-in mice display the splicing defect seen in human MDS but develop anemia without ring sideroblasts.Transcriptomic Characterization of SF3B1 Mutation Reveals Its Pleiotropic Effects in Chronic Lymphocytic Leukemia.Alternative splicing: the pledge, the turn, and the prestige : The key role of alternative splicing in human biological systems.Cryptic splicing events in the iron transporter ABCB7 and other key target genes in SF3B1-mutant myelodysplastic syndromes.Splicing-factor alterations in cancers.Therapeutic targeting of splicing in cancer.Large-scale analysis of branchpoint usage across species and cell lines.Splicing factor gene mutations in hematologic malignancies.Splicing Factor Mutations in Myelodysplasias: Insights from Spliceosome Structures.Chronic lymphocytic leukaemia genomics and the precision medicine era.Focus on cutaneous and uveal melanoma specificities.RNA processing as an alternative route to attack glioblastoma.Integrative Analysis Identifies Four Molecular and Clinical Subsets in Uveal Melanoma.Physiologic Expression of Sf3b1(K700E) Causes Impaired Erythropoiesis, Aberrant Splicing, and Sensitivity to Therapeutic Spliceosome Modulation.Multiple Isoforms of ANRIL in Melanoma Cells: Structural Complexity Suggests Variations in Processing.A GWAS in uveal melanoma identifies risk polymorphisms in the CLPTM1L locus.Partial loss of genes might open therapeutic window.CLK-dependent exon recognition and conjoined gene formation revealed with a novel small molecule inhibitor.The role of alternative splicing in cancer.Whole-exome sequencing identifies recurrent SF3B1 R625 mutation and comutation of NF1 and KIT in mucosal melanoma.FIR haplodeficiency promotes splicing to pyruvate kinase M2 in mice thymic lymphoma tissues revealed by six-plex tandem mass tag quantitative proteomic analysis.Modeling Myeloid Malignancies Using Zebrafish.Molecular basis of differential 3' splice site sensitivity to anti-tumor drugs targeting U2 snRNP.Melanoma: Genetic Abnormalities, Tumor Progression, Clonal Evolution and Tumor Initiating Cells.Fanconi anemia FANCD2 and FANCI proteins regulate the nuclear dynamics of splicing factors.Mechanistic insights into precursor messenger RNA splicing by the spliceosome.SF3B1 deficiency impairs human erythropoiesis via activation of p53 pathway: implications for understanding of ineffective erythropoiesis in MDS.

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P2860

Cancer-associated SF3B1 mutations affect alternative splicing by promoting alternative branchpoint usage.

http://www.wikidata.org/entity/Q36549378

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2016 nî lūn-bûn

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2016年論文

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2016年论文

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2016年论文

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Cancer-associated SF3B1 mutati ...... alternative branchpoint usage.

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Cancer-associated SF3B1 mutati ...... alternative branchpoint usage.

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Cancer-associated SF3B1 mutati ...... alternative branchpoint usage.

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Cancer-associated SF3B1 mutati ...... alternative branchpoint usage.

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Nature Communications

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Cancer-associated SF3B1 mutati ...... alternative branchpoint usage.

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Alexandre Houy

http://www.w3.org/2001/XMLSchema#string

Angelos Constantinou

http://www.w3.org/2001/XMLSchema#string

Aude Battistella

http://www.w3.org/2001/XMLSchema#string

Emilie Henry

http://www.w3.org/2001/XMLSchema#string

Michel Wassef

http://www.w3.org/2001/XMLSchema#string

Samar Alsafadi

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Tatiana Popova

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P2860

Genome-wide association between branch point properties and alternative splicing

TopHat2: accurate alignment of transcriptomes in the presence of insertions, deletions and gene fusions

A potential role for U2AF-SAP 155 interactions in recruiting U2 snRNP to the branch site

Misregulation of pre-mRNA alternative splicing in cancer

SF3B1 mutations constitute a novel therapeutic target in breast cancer.

WebLogo: A Sequence Logo Generator

The spliceosome: design principles of a dynamic RNP machine

Exome sequencing identifies recurrent mutations of the splicing factor SF3B1 gene in chronic lymphocytic leukemia

Moderated estimation of fold change and dispersion for RNA-seq data with DESeq2

Frequent pathway mutations of splicing machinery in myelodysplasia

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10.1038/NCOMMS10615

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7

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Sophie Piperno-Neumann

Sergio Roman-Roman

Marc-Henri Stern

Martin Dutertre

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2016-02-04T00:00:00Z

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293042711

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26842708

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4743009

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