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Molecular profiling of patient-derived breast cancer xenograftsUpcoming translational challenges for uveal melanomaLDL receptor-related protein 5 (LRP5) affects bone accrual and eye developmentCharacterization of Breast Cancer Preclinical Models Reveals a Specific Pattern of Macrophage PolarizationMurine Frizzled-1 behaves as an antagonist of the canonical Wnt/beta-catenin signalingFinding genes in the C2C12 osteogenic pathway by k-nearest-neighbor classification of expression data.Vasculature analysis of patient derived tumor xenografts using species-specific PCR assays: evidence of tumor endothelial cells and atypical VEGFA-VEGFR1/2 signalingsA genomic and transcriptomic approach for a differential diagnosis between primary and secondary ovarian carcinomas in patients with a previous history of breast cancerLrp5-independent activation of Wnt signaling by lithium chloride increases bone formation and bone mass in micePatient-derived xenograft models: an emerging platform for translational cancer researchPredictive gene signature of response to the anti-TweakR mAb PDL192 in patient-derived breast cancer xenograftsWnt signaling: a key regulator of bone mass.TTK/hMPS1 is an attractive therapeutic target for triple-negative breast cancer.Transcriptome analysis of Wnt3a-treated triple-negative breast cancer cells.Evaluating patient-derived colorectal cancer xenografts as preclinical models by comparison with patient clinical data.Nanobodies against surface biomarkers enable the analysis of tumor genetic heterogeneity in uveal melanoma patient-derived xenografts.Wnt signalling pathway: a new target for the treatment of osteoporosis.Cancer-associated SF3B1 mutations affect alternative splicing by promoting alternative branchpoint usage.Activation of IFN/STAT1 signalling predicts response to chemotherapy in oestrogen receptor-negative breast cancerMutational analysis of anal cancers demonstrates frequent PIK3CA mutations associated with poor outcome after salvage abdominoperineal resection.The mTOR inhibitor Everolimus synergizes with the PI3K inhibitor GDC0941 to enhance anti-tumor efficacy in uveal melanoma.SF3B1 mutations are associated with alternative splicing in uveal melanoma.In vitro processing of human tumor necrosis factor-alpha.Patient-derived xenografts recapitulate molecular features of human uveal melanomas.Clinical value of R-spondins in triple-negative and metaplastic breast cancers.Establishment of novel cell lines recapitulating the genetic landscape of uveal melanoma and preclinical validation of mTOR as a therapeutic target.Interrogating open issues in cancer precision medicine with patient-derived xenografts.Polo-like kinase 1: a potential therapeutic option in combination with conventional chemotherapy for the management of patients with triple-negative breast cancer.Integrative Analysis Identifies Four Molecular and Clinical Subsets in Uveal Melanoma.AIP4 restricts transforming growth factor-beta signaling through a ubiquitination-independent mechanism.Gene array analysis of Wnt-regulated genes in C3H10T1/2 cells.Interaction between LRP5 and Frat1 mediates the activation of the Wnt canonical pathway.BMP-2 controls alkaline phosphatase expression and osteoblast mineralization by a Wnt autocrine loop.Involvement of small GTPases in Mycoplasma fermentans membrane lipoproteins-mediated activation of macrophages.Histo-genomic stratification reveals the frequent amplification/overexpression of CCNE1 and BRD4 genes in non-BRCAness high grade ovarian carcinoma.TIPIN depletion leads to apoptosis in breast cancer cells.Dual inhibition of protein kinase C and p53-MDM2 or PKC and mTORC1 are novel efficient therapeutic approaches for uveal melanoma.Upcoming translational challenges for uveal melanoma.Establishment and characterization of a panel of human uveal melanoma xenografts derived from primary and/or metastatic tumors.Characterization of a large panel of patient-derived tumor xenografts representing the clinical heterogeneity of human colorectal cancer.
P50
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P50
description
hulumtues
@sq
onderzoeker
@nl
researcher
@en
հետազոտող
@hy
name
Sergio Roman-Roman
@ast
Sergio Roman-Roman
@en
Sergio Roman-Roman
@es
Sergio Roman-Roman
@sl
type
label
Sergio Roman-Roman
@ast
Sergio Roman-Roman
@en
Sergio Roman-Roman
@es
Sergio Roman-Roman
@sl
altLabel
Sergio Roman-roman
@en
prefLabel
Sergio Roman-Roman
@ast
Sergio Roman-Roman
@en
Sergio Roman-Roman
@es
Sergio Roman-Roman
@sl
P1053
K-9993-2014
P106
P1153
7003815237
P21
P31
P3829
P496
0000-0001-6459-2613