Bioactivation of Selective Estrogen Receptor Modulators (SERMs)
about
Formation and Biological Targets of Quinones: Cytotoxic versus Cytoprotective EffectsComparative methods for analysis of protein covalent modification by electrophilic quinoids formed from xenobiotics.SERMs attenuate estrogen-induced malignant transformation of human mammary epithelial cells by upregulating detoxification of oxidative metabolites.Selective estrogen receptor modulators: tissue specificity and clinical utility.Endoxifen and other metabolites of tamoxifen inhibit human hydroxysteroid sulfotransferase 2A1 (hSULT2A1).Quinone Methide Bioactivation Pathway: Contribution to Toxicity and/or Cytoprotection?Benzothiophene Selective Estrogen Receptor Modulators Provide Neuroprotection by a novel GPR30-dependent MechanismConstruction of a database for the evaluation and the clinical management of patients with breast cancer treated with antiestrogens and/or aromatase inhibitors.Oxidative metabolism of ferrocene analogues of tamoxifen: characterization and antiproliferative activities of the metabolites.The naphthol selective estrogen receptor modulator (SERM), LY2066948, is oxidized to an o-quinone analogous to the naphthol equine estrogen, equilenin.Selective estrogen receptor modulator (SERM) lasofoxifene forms reactive quinones similar to estradiolUterine peroxidase-catalyzed formation of diquinone methides from the selective estrogen receptor modulators raloxifene and desmethylated arzoxifeneTARGETING THE GENOTOXIC EFFECTS OF ESTROGENS.Structural modulation of oxidative metabolism in design of improved benzothiophene selective estrogen receptor modulators.Selective estrogen receptor modulator BC-1 activates antioxidant signaling pathway in vitro via formation of reactive metabolitesMeasuring selective estrogen receptor modulator (SERM)-membrane interactions with second harmonic generationPractical approaches to resolving reactive metabolite liabilities in early discovery.Is molecular alignment an indispensable requirement in the MIA-QSAR method?Non-cytochrome P450-mediated bioactivation and its toxicological relevance.Characterization of the biotransformation pathways of clomiphene, tamoxifen and toremifene as assessed by LC-MS/(MS) following in vitro and excretion studies.
P2860
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P2860
Bioactivation of Selective Estrogen Receptor Modulators (SERMs)
description
2006 nî lūn-bûn
@nan
2006年の論文
@ja
2006年論文
@yue
2006年論文
@zh-hant
2006年論文
@zh-hk
2006年論文
@zh-mo
2006年論文
@zh-tw
2006年论文
@wuu
2006年论文
@zh
2006年论文
@zh-cn
name
Bioactivation of Selective Estrogen Receptor Modulators (SERMs)
@ast
Bioactivation of Selective Estrogen Receptor Modulators (SERMs)
@en
type
label
Bioactivation of Selective Estrogen Receptor Modulators (SERMs)
@ast
Bioactivation of Selective Estrogen Receptor Modulators (SERMs)
@en
prefLabel
Bioactivation of Selective Estrogen Receptor Modulators (SERMs)
@ast
Bioactivation of Selective Estrogen Receptor Modulators (SERMs)
@en
P2093
P2860
P356
P1476
Bioactivation of Selective Estrogen Receptor Modulators (SERMs)
@en
P2093
Gregory R J Thatcher
Judy L Bolton
Tamara S Dowers
Zhi-Hui Qin
P2860
P304
P356
10.1021/TX060126V
P577
2006-09-01T00:00:00Z