RNF4 is required for DNA double-strand break repair in vivo. - Test2 - elhamkhani - TriplyDB

RNF4 is required for DNA double-strand break repair in vivo.

RNF4 is required for DNA double-strand break repair in vivo.

http://www.wikidata.org/entity/Q36603136

about

RNF4 interacts with both SUMO and nucleosomes to promote the DNA damage response Role of Deubiquitinating Enzymes in DNA Repair DNA repair and aging: the impact of the p53 family RPA-coated single-stranded DNA as a platform for post-translational modifications in the DNA damage response Multivalent interactions of the SUMO-interaction motifs in RING finger protein 4 determine the specificity for chains of the SUMO Exploring the RING-catalyzed ubiquitin transfer mechanism by MD and QM/MM calculations.An arginine-rich motif of ring finger protein 4 (RNF4) oversees the recruitment and degradation of the phosphorylated and SUMOylated Krüppel-associated box domain-associated protein 1 (KAP1)/TRIM28 protein during genotoxic stress.Ube2W conjugates ubiquitin to α-amino groups of protein N-termini BLM SUMOylation regulates ssDNA accumulation at stalled replication forks.RNF4-mediated polyubiquitination regulates the Fanconi anemia/BRCA pathway.RNF4 negatively regulates NF-κB signaling by down-regulating TAB2.Silencing NFBD1/MDC1 enhances the radiosensitivity of human nasopharyngeal cancer CNE1 cells and results in tumor growth inhibition.SUMO-targeted ubiquitin ligase activity can either suppress or promote genome instability, depending on the nature of the DNA lesion.RNF4 regulates DNA double-strand break repair in a cell cycle-dependent manner DNA damage emergency: cellular garbage disposal to the rescue?Decoding the SUMO signal.Reading, writing, and repair: the role of ubiquitin and the ubiquitin-like proteins in DNA damage signaling and repair.SUMO rules: regulatory concepts and their implication in neurologic functions.RNA splicing: a new player in the DNA damage response Two-way communications between ubiquitin-like modifiers and DNA.SUMO chain-induced dimerization activates RNF4.Ubiquitin-dependent and independent roles of SUMO in proteostasis.c-Myc is targeted to the proteasome for degradation in a SUMOylation-dependent manner, regulated by PIAS1, SENP7 and RNF4 System-wide Analysis of SUMOylation Dynamics in Response to Replication Stress Reveals Novel Small Ubiquitin-like Modified Target Proteins and Acceptor Lysines Relevant for Genome Stability.Ubiquitin-SUMO circuitry controls activated fanconi anemia ID complex dosage in response to DNA damage On-site remodeling at chromatin: How multiprotein complexes are rebuilt during DNA repair and transcriptional activation.Remodeling and spacing factor 1 (RSF1) deposits centromere proteins at DNA double-strand breaks to promote non-homologous end-joining Functions of SUMO in the Maintenance of Genome Stability.Slx5/Slx8 Promotes Replication Stress Tolerance by Facilitating Mitotic Progression RNF4-mediated SUMOylation is essential for NDRG2 suppression of lung adenocarcinoma SUMO-2 Orchestrates Chromatin Modifiers in Response to DNA Damage.Ubiquitin-specific Protease 11 (USP11) Deubiquitinates Hybrid Small Ubiquitin-like Modifier (SUMO)-Ubiquitin Chains to Counteract RING Finger Protein 4 (RNF4).Structural basis for the RING-catalyzed synthesis of K63-linked ubiquitin chains.Ataxin-3 consolidates the MDC1-dependent DNA double-strand break response by counteracting the SUMO-targeted ubiquitin ligase RNF4.A mediator methylation mystery: JMJD1C demethylates MDC1 to regulate DNA repair The STUbL RNF4 regulates protein group SUMOylation by targeting the SUMO conjugation machinery.Dynamics of RIF1 SUMOylation is regulated by PIAS4 in the maintenance of Genomic Stability.Converging Small Ubiquitin-like Modifier (SUMO) and Ubiquitin Signaling: Improved Methodology Identifies Co-modified Target Proteins.MEIOTIC F-BOX Is Essential for Male Meiotic DNA Double-Strand Break Repair in Rice.RAP80 is an independent prognosis biomarker for the outcome of patients with esophageal squamous cell carcinoma.

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P2860

RNF4 is required for DNA double-strand break repair in vivo.

http://www.wikidata.org/entity/Q36603136

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name

RNF4 is required for DNA double-strand break repair in vivo.

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RNF4 is required for DNA double-strand break repair in vivo.

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RNF4 is required for DNA double-strand break repair in vivo.

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RNF4 is required for DNA double-strand break repair in vivo.

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RNF4 is required for DNA double-strand break repair in vivo.

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RNF4 is required for DNA double-strand break repair in vivo.

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P2860

MDC1 directly binds phosphorylated histone H2AX to regulate cellular responses to DNA double-strand breaks

RNF8 ubiquitylates histones at DNA double-strand breaks and promotes assembly of repair proteins

RNF8 transduces the DNA-damage signal via histone ubiquitylation and checkpoint protein assembly

RNF4 is a poly-SUMO-specific E3 ubiquitin ligase required for arsenic-induced PML degradation

The DNA-damage response in human biology and disease

Dynamics of DNA damage response proteins at DNA breaks: a focus on protein modifications

Mammalian SUMO E3-ligases PIAS1 and PIAS4 promote responses to DNA double-strand breaks

Orchestration of the DNA-damage response by the RNF8 ubiquitin ligase

The DNA Damage Response: Making It Safe to Play with Knives

DNA double-stranded breaks induce histone H2AX phosphorylation on serine 139

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