Pharmacologic blockade of FAK autophosphorylation decreases human glioblastoma tumor growth and synergizes with temozolomide.
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FAK and paxillin, two potential targets in pancreatic cancerBiological basis and clinical study of glycogen synthase kinase- 3β-targeted therapy by drug repositioning for glioblastoma.Microenvironmental stiffness enhances glioma cell proliferation by stimulating epidermal growth factor receptor signaling.Transmembrane-Bound IL-15-Promoted Epithelial-Mesenchymal Transition in Renal Cancer Cells Requires the Src-Dependent Akt/GSK-3β/β-Catenin Pathway.Tumor Necrosis Factor-α (TNFα)-induced Ceramide Generation via Ceramide Synthases Regulates Loss of Focal Adhesion Kinase (FAK) and Programmed Cell Death.Anti-metastatic action of FAK inhibitor OXA-11 in combination with VEGFR-2 signaling blockade in pancreatic neuroendocrine tumorsFluvoxamine, an anti-depressant, inhibits human glioblastoma invasion by disrupting actin polymerization.Disrupting the scaffold to improve focal adhesion kinase-targeted cancer therapeuticsTargeting Focal Adhesion Kinase Suppresses the Malignant Phenotype in Rhabdomyosarcoma CellsThe FAK scaffold inhibitor C4 disrupts FAK-VEGFR-3 signaling and inhibits pancreatic cancer growth.FAK inhibition abrogates the malignant phenotype in aggressive pediatric renal tumorsGlutamate transporters in the biology of malignant gliomasTargeting angiogenesis and the tumor microenvironment.Implications of Rho GTPase Signaling in Glioma Cell Invasion and Tumor Progression.Targeting FAK in human cancer: from finding to first clinical trials.The diverse roles and multiple forms of focal adhesion kinase in brain.Molecular Targeting of Integrins and Integrin-Associated Signaling Networks in Radiation Oncology.Down-regulation of ALDH1A3, CD44 or MDR1 sensitizes resistant cancer cells to FAK autophosphorylation inhibitor Y15.In vivo toxicity, metabolism and pharmacokinetic properties of FAK inhibitor 14 or Y15 (1, 2, 4, 5-benzenetetramine tetrahydrochloride).The microarray gene profiling analysis of glioblastoma cancer cells reveals genes affected by FAK inhibitor Y15 and combination of Y15 and temozolomide.Focal adhesion kinase regulates expression of thioredoxin-interacting protein (TXNIP) in cancer cells.Syndecan-1 knockdown inhibits glioma cell proliferation and invasion by deregulating a c-src/FAK-associated signaling pathway.Disrupting the scaffold, an alternative approach to inhibiting FAK.Naringin suppresses the development of glioblastoma by inhibiting FAK activity.PTK2-mediated degradation of ATG3 impedes cancer cells susceptible to DNA damage treatment.A phase I study of VS-6063, a second-generation focal adhesion kinase inhibitor, in patients with advanced solid tumors.Small-molecule inhibitors of FGFR, integrins and FAK selectively decrease L1CAM-stimulated glioblastoma cell motility and proliferation.Cell density modulates SHC3 expression and survival of human glioblastoma cells through Fak activation.Targeting Focal Adhesion Kinase Using Inhibitors of Protein-Protein Interactions
P2860
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P2860
Pharmacologic blockade of FAK autophosphorylation decreases human glioblastoma tumor growth and synergizes with temozolomide.
description
2012 nî lūn-bûn
@nan
2012年の論文
@ja
2012年論文
@yue
2012年論文
@zh-hant
2012年論文
@zh-hk
2012年論文
@zh-mo
2012年論文
@zh-tw
2012年论文
@wuu
2012年论文
@zh
2012年论文
@zh-cn
name
Pharmacologic blockade of FAK ...... synergizes with temozolomide.
@ast
Pharmacologic blockade of FAK ...... synergizes with temozolomide.
@en
type
label
Pharmacologic blockade of FAK ...... synergizes with temozolomide.
@ast
Pharmacologic blockade of FAK ...... synergizes with temozolomide.
@en
prefLabel
Pharmacologic blockade of FAK ...... synergizes with temozolomide.
@ast
Pharmacologic blockade of FAK ...... synergizes with temozolomide.
@en
P2093
P2860
P1476
Pharmacologic blockade of FAK ...... d synergizes with temozolomide
@en
P2093
Baotran Ho
Carl D Morrison
Grace Huang
Jisook Lee
Michael Yemma
Vita M Golubovskaya
William G Cance
P2860
P304
P356
10.1158/1535-7163.MCT-12-0701
P577
2012-12-12T00:00:00Z