Direct interaction of the N-terminal domain of focal adhesion kinase with the N-terminal transactivation domain of p53
about
Nuclear FAK promotes cell proliferation and survival through FERM-enhanced p53 degradationRole of p53/FAK association and p53Ser46 phosphorylation in staurosporine-mediated apoptosis: wild type versus mutant p53-R175HPyk2 inhibition of p53 as an adaptive and intrinsic mechanism facilitating cell proliferation and survivalFocal adhesions regulate Abeta signaling and cell death in Alzheimer's diseaseAdhesion protein networks reveal functions proximal and distal to cell-matrix contactsFAK dimerization controls its kinase-dependent functions at focal adhesionsHEF1-aurora A interactions: points of dialog between the cell cycle and cell attachment signaling networksFocal adhesion kinase protein levels in gut epithelial motilityFocal adhesion kinase and endothelial cell apoptosis.Focal adhesion kinase: a prominent determinant in breast cancer initiation, progression and metastasisMechanical signaling through the cytoskeleton regulates cell proliferation by coordinated focal adhesion and Rho GTPase signaling.αν and β1 Integrins mediate Aβ-induced neurotoxicity in hippocampal neurons via the FAK signaling pathway.Disruption of focal adhesion kinase and p53 interaction with small molecule compound R2 reactivated p53 and blocked tumor growth.Understanding the roles of FAK in cancer: inhibitors, genetic models, and new insightsInhibition of FAK and VEGFR-3 binding decreases tumorigenicity in neuroblastoma.Role of extracellular matrix renal tubulo-interstitial nephritis antigen (TINag) in cell survival utilizing integrin (alpha)vbeta3/focal adhesion kinase (FAK)/phosphatidylinositol 3-kinase (PI3K)/protein kinase B-serine/threonine kinase (AKT) signalHow focal adhesion kinase achieves regulation by linking ligand binding, localization and actionFocal adhesion kinase and p53 synergistically decrease neuroblastoma cell survival.RNAi-mediated inhibition of MSP58 decreases tumour growth, migration and invasion in a human glioma cell line.Nanog increases focal adhesion kinase (FAK) promoter activity and expression and directly binds to FAK protein to be phosphorylated.Nuclear-localized focal adhesion kinase regulates inflammatory VCAM-1 expression.Pharmacogenomic profiling and pathway analyses identify MAPK-dependent migration as an acute response to SN38 in p53 null and p53-mutant colorectal cancer cells.Focal Adhesion Kinase: Insight into Molecular Roles and Functions in Hepatocellular CarcinomaPharmacologic blockade of FAK autophosphorylation decreases human glioblastoma tumor growth and synergizes with temozolomide.A small-molecule inhibitor, 5'-O-tritylthymidine, targets FAK and Mdm-2 interaction, and blocks breast and colon tumorigenesis in vivo.A novel small molecule inhibitor of FAK decreases growth of human pancreatic cancer.Progesterone receptor isoforms PRA and PRB differentially contribute to breast cancer cell migration through interaction with focal adhesion kinase complexesRole of FAK in S1P-regulated endothelial permeability.Mammary epithelial-specific disruption of focal adhesion kinase retards tumor formation and metastasis in a transgenic mouse model of human breast cancer.Disrupting the scaffold to improve focal adhesion kinase-targeted cancer therapeuticsSmooth muscle hyperplasia due to loss of smooth muscle α-actin is driven by activation of focal adhesion kinase, altered p53 localization and increased levels of platelet-derived growth factor receptor-β.A small molecule inhibitor, 1,2,4,5-benzenetetraamine tetrahydrochloride, targeting the y397 site of focal adhesion kinase decreases tumor growth.Focal adhesion kinase versus p53: apoptosis or survival?FERM control of FAK function: implications for cancer therapy.Targeting the p53 pathway.Adenoviruses increase endothelial cell proliferation, migration, and tube formation: partial reversal by the focal adhesion kinase inhibitor, FRNK.FAK overexpression and p53 mutations are highly correlated in human breast cancer.Focal adhesion complex proteins in epidermis and squamous cell carcinoma.Autophosphorylation-independent and -dependent functions of focal adhesion kinase during development.Regulation of p53--insights into a complex process.
P2860
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P2860
Direct interaction of the N-terminal domain of focal adhesion kinase with the N-terminal transactivation domain of p53
description
2005 nî lūn-bûn
@nan
2005 թուականի Յուլիսին հրատարակուած գիտական յօդուած
@hyw
2005 թվականի հուլիսին հրատարակված գիտական հոդված
@hy
2005年の論文
@ja
2005年論文
@yue
2005年論文
@zh-hant
2005年論文
@zh-hk
2005年論文
@zh-mo
2005年論文
@zh-tw
2005年论文
@wuu
name
Direct interaction of the N-te ...... transactivation domain of p53
@ast
Direct interaction of the N-te ...... transactivation domain of p53
@en
Direct interaction of the N-te ...... transactivation domain of p53
@en-gb
Direct interaction of the N-te ...... transactivation domain of p53
@nl
type
label
Direct interaction of the N-te ...... transactivation domain of p53
@ast
Direct interaction of the N-te ...... transactivation domain of p53
@en
Direct interaction of the N-te ...... transactivation domain of p53
@en-gb
Direct interaction of the N-te ...... transactivation domain of p53
@nl
prefLabel
Direct interaction of the N-te ...... transactivation domain of p53
@ast
Direct interaction of the N-te ...... transactivation domain of p53
@en
Direct interaction of the N-te ...... transactivation domain of p53
@en-gb
Direct interaction of the N-te ...... transactivation domain of p53
@nl
P2093
P3181
P356
P1476
Direct interaction of the N-te ...... transactivation domain of p53
@en
P2093
Richard Finch
Vita M Golubovskaya
William G Cance
P304
P3181
P356
10.1074/JBC.M414172200
P407
P577
2005-07-01T00:00:00Z