Impaired activity-dependent FMRP translation and enhanced mGluR-dependent LTD in Fragile X premutation mice
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Synaptic Plasticity, a Prominent Contributor to the Anxiety in Fragile X SyndromeSingle-Nucleotide Mutations in FMR1 Reveal Novel Functions and Regulatory Mechanisms of the Fragile X Syndrome Protein FMRPFragile X-associated tremor/ataxia syndrome.The unstable repeats--three evolving faces of neurological diseaseModeling Fragile X Syndrome Using Human Pluripotent Stem CellsPhosphorylation of FMRP and alterations of FMRP complex underlie enhanced mLTD in adult rats triggered by early life seizures.Impaired sensorimotor gating in Fmr1 knock out and Fragile X premutation model mice.FMRP S499 is phosphorylated independent of mTORC1-S6K1 activity.Reduced excitatory amino acid transporter 1 and metabotropic glutamate receptor 5 expression in the cerebellum of fragile X mental retardation gene 1 premutation carriers with fragile X-associated tremor/ataxia syndrome.Mouse models of the fragile X premutation and fragile X-associated tremor/ataxia syndromeA 3' untranslated region variant in FMR1 eliminates neuronal activity-dependent translation of FMRP by disrupting binding of the RNA-binding protein HuRFragile X mental retardation protein expression in Alzheimer's diseaseRepeat-associated non-AUG translation and its impact in neurodegenerative disease.Loss of F-box only protein 2 (Fbxo2) disrupts levels and localization of select NMDA receptor subunits, and promotes aberrant synaptic connectivity.Enhanced asynchronous Ca(2+) oscillations associated with impaired glutamate transport in cortical astrocytes expressing Fmr1 gene premutation expansionFragile X-associated tremor/ataxia syndrome (FXTAS): pathology and mechanisms.F-box only protein 2 (Fbxo2) regulates amyloid precursor protein levels and processing.Reduced activity-dependent protein levels in a mouse model of the fragile X premutation.Annual research review: Rare genotypes and childhood psychopathology--uncovering diverse developmental mechanisms of ADHD risk.Fragile X-Associated Tremor/Ataxia Syndrome (FXTAS) Motor Dysfunction Modeled in MiceCalcium dysregulation and Cdk5-ATM pathway involved in a mouse model of fragile X-associated tremor/ataxia syndrome.Neonatal maternal deprivation impairs localized de novo activity-induced protein translation at the synapse in the rat hippocampus.BC RNA Mislocalization in the Fragile X Premutation.Impaired GABA Neural Circuits Are Critical for Fragile X SyndromeTargeted Reactivation of Transcription in Fragile X Syndrome Embryonic Stem Cells
P2860
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P2860
Impaired activity-dependent FMRP translation and enhanced mGluR-dependent LTD in Fragile X premutation mice
description
2012 nî lūn-bûn
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2012年の論文
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2012年論文
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2012年論文
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2012年論文
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2012年論文
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2012年論文
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name
Impaired activity-dependent FM ...... in Fragile X premutation mice
@ast
Impaired activity-dependent FM ...... in Fragile X premutation mice
@en
type
label
Impaired activity-dependent FM ...... in Fragile X premutation mice
@ast
Impaired activity-dependent FM ...... in Fragile X premutation mice
@en
prefLabel
Impaired activity-dependent FM ...... in Fragile X premutation mice
@ast
Impaired activity-dependent FM ...... in Fragile X premutation mice
@en
P2093
P2860
P356
P1476
Impaired activity-dependent FM ...... in Fragile X premutation mice
@en
P2093
Abigail J Renoux
Karen Usdin
Michael A Sutton
Peter K Todd
P2860
P304
P356
10.1093/HMG/DDS525
P50
P577
2012-12-18T00:00:00Z