The basal-like mammary carcinomas induced by Brca1 or Bard1 inactivation implicate the BRCA1/BARD1 heterodimer in tumor suppression. - Test2 - elhamkhani - TriplyDB

The basal-like mammary carcinomas induced by Brca1 or Bard1 inactivation implicate the BRCA1/BARD1 heterodimer in tumor suppression.

The basal-like mammary carcinomas induced by Brca1 or Bard1 inactivation implicate the BRCA1/BARD1 heterodimer in tumor suppression.

http://www.wikidata.org/entity/Q36627600

about

The UBXN1 protein associates with autoubiquitinated forms of the BRCA1 tumor suppressor and inhibits its enzymatic function Modeling the study of DNA damage responses in mice Homologous recombination and human health: the roles of BRCA1, BRCA2, and associated proteins Luring BRCA1 to the scene of the crime Functional and mutational landscapes of BRCA1 for homology-directed repair and therapy resistance BARD1 Gene Polymorphisms Confer Nephroblastoma Susceptibility.Genome-wide approaches to systematically identify substrates of the ubiquitin-proteasome pathway BRCA1 and BRCA2: breast/ovarian cancer susceptibility gene products and participants in DNA double-strand break repair.Mouse models of inherited cancer syndromes BRCA1, PARP, and 53BP1: conditional synthetic lethality and synthetic viability.The role of BRCA1 in DNA damage response.Deciphering the BRCA1 Tumor Suppressor Network.BARD1 expression predicts outcome in colon cancer.BRCA1 deficient mouse models to study pathogenesis and therapy of triple negative breast cancer.Mammary tumors initiated by constitutive Cdk2 activation contain an invasive basal-like component.E3 ligase activity of BRCA1 is not essential for mammalian cell viability or homology-directed repair of double-strand DNA breaks.Autophagy opposes p53-mediated tumor barrier to facilitate tumorigenesis in a model of PALB2-associated hereditary breast cancer.The potential role of nanotechnology in therapeutic approaches for triple negative breast cancer.Perturbation of DNA repair pathways by proteasome inhibitors corresponds to enhanced chemosensitivity of cells to DNA damage-inducing agents.The DNA resection protein CtIP promotes mammary tumorigenesis.Preclinical mouse models for BRCA1-associated breast cancer.BRCA1 and its toolbox for the maintenance of genome integrity BRCA1 tumor suppression depends on BRCT phosphoprotein binding, but not its E3 ligase activity.Novel clinico-genome network modeling for revolutionizing genotype-phenotype-based personalized cancer care.The BRCA1 ubiquitin ligase and homologous recombination repair.Targeted mutagenesis of zebrafish: use of zinc finger nucleases.BRACking news on triple-negative/basal-like breast cancers: how BRCA1 deficiency may result in the development of a selective tumor subtype.Mouse models of BRCA1 and their application to breast cancer research.Cancer and heterogeneity of obesity: a potential contribution of brown fat.Opportunities and hurdles in the treatment of BRCA1-related breast cancer.Functional Analysis of BARD1 Missense Variants in Homology-Directed Repair of DNA Double Strand Breaks.Hereditary breast and ovarian cancer: new genes in confined pathways.MicroRNA-206 is differentially expressed in Brca1-deficient mice and regulates epithelial and stromal cell compartments of the mouse mammary gland Frequent incidence of BARD1-truncating mutations in germline DNA from triple-negative breast cancer patients.RING Finger Protein 38 Is a Neuronal Protein in the Brain of Nile Tilapia, Oreochromis niloticus 53BP1 ablation rescues genomic instability in mice expressing 'RING-less' BRCA1 Chemopreventive Effects of ROS Targeting in a Murine Model of BRCA1-Deficient Breast Cancer.Ubiquitin ligases in oncogenic transformation and cancer therapy.Dualistic Role of BARD1 in Cancer.BRCA1 forms a heterodimer with BARD1

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P2860

The basal-like mammary carcinomas induced by Brca1 or Bard1 inactivation implicate the BRCA1/BARD1 heterodimer in tumor suppression.

http://www.wikidata.org/entity/Q36627600

description

2008 nî lūn-bûn

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2008年の論文

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2008年論文

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2008年論文

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2008年論文

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2008年論文

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2008年論文

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2008年论文

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2008年论文

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2008年论文

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The basal-like mammary carcino ...... erodimer in tumor suppression.

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The basal-like mammary carcino ...... erodimer in tumor suppression.

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The basal-like mammary carcino ...... erodimer in tumor suppression.

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The basal-like mammary carcino ...... erodimer in tumor suppression.

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The basal-like mammary carcino ...... erodimer in tumor suppression.

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The basal-like mammary carcino ...... erodimer in tumor suppression.

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The basal-like mammary carcino ...... erodimer in tumor suppression.

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Ellen McCarthy

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Elson Ospina

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Katia Basso

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Matthias Szabolcs

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Reena Shakya

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Richard Baer

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Subhadra Nandula

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Thomas Ludwig

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Vundavalli Murty

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P2860

Nuclear localization and cell cycle-specific expression of CtIP, a protein that associates with the BRCA1 tumor suppressor

Identification of a RING protein that can interact in vivo with the BRCA1 gene product

Cell cycle-dependent colocalization of BARD1 and BRCA1 proteins in discrete nuclear domains

Repeated observation of breast tumor subtypes in independent gene expression data sets

The RING heterodimer BRCA1-BARD1 is a ubiquitin ligase inactivated by a breast cancer-derived mutation

Identification of BARD1 as mediator between proapoptotic stress and p53-dependent apoptosis

The BRCA1/BARD1 heterodimer, a tumor suppressor complex with ubiquitin E3 ligase activity

Mutations in the BRCA1-associated RING domain (BARD1) gene in primary breast, ovarian and uterine cancers

The BRCA1/BARD1 heterodimer modulates ran-dependent mitotic spindle assembly

Minding the gap: the underground functions of BRCA1 and BRCA2 at stalled replication forks

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