Functional and mutational landscapes of BRCA1 for homology-directed repair and therapy resistance
about
Small-Molecule Inhibitors Targeting DNA Repair and DNA Repair Deficiency in Research and Cancer Therapy.BLM helicase regulates DNA repair by counteracting RAD51 loading at DNA double-strand break sites.Acquired resistance of phosphatase and tensin homolog-deficient cells to poly(ADP-ribose) polymerase inhibitor and Ara-C mediated by 53BP1 loss and SAMHD1 overexpression.How cells ensure correct repair of DNA double-strand breaks.ATM loss leads to synthetic lethality in BRCA1 BRCT mutant mice associated with exacerbated defects in homology-directed repair.RNF169 limits 53BP1 deposition at DSBs to stimulate single-strand annealing repairRepeat-mediated deletions can be induced by a chromosomal break far from a repeat, but multiple pathways suppress such rearrangementsHomology-Directed Repair and the Role of BRCA1, BRCA2, and Related Proteins in Genome Integrity and CancerTwo Missense Variants Detected in Breast Cancer Probands Preventing BRCA2-PALB2 Protein InteractionBRCA1 Mutation-Specific Responses to 53BP1 Loss-Induced Homologous Recombination and PARP Inhibitor Resistance
P2860
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P2860
Functional and mutational landscapes of BRCA1 for homology-directed repair and therapy resistance
description
2017 nî lūn-bûn
@nan
2017 թուականի Ապրիլին հրատարակուած գիտական յօդուած
@hyw
2017 թվականի ապրիլին հրատարակված գիտական հոդված
@hy
2017年の論文
@ja
2017年論文
@yue
2017年論文
@zh-hant
2017年論文
@zh-hk
2017年論文
@zh-mo
2017年論文
@zh-tw
2017年论文
@wuu
name
Functional and mutational land ...... repair and therapy resistance
@ast
Functional and mutational land ...... repair and therapy resistance
@en
type
label
Functional and mutational land ...... repair and therapy resistance
@ast
Functional and mutational land ...... repair and therapy resistance
@en
prefLabel
Functional and mutational land ...... repair and therapy resistance
@ast
Functional and mutational land ...... repair and therapy resistance
@en
P2093
P2860
P50
P356
P1433
P1476
Functional and mutational land ...... repair and therapy resistance
@en
P2093
Jingmei Liu
Rachel W Anantha
Shridar Ganesan
Srilatha Simhadri
Susanna Miao
P2860
P356
10.7554/ELIFE.21350
P407
P577
2017-04-11T00:00:00Z