Functional genomic screening identifies dual leucine zipper kinase as a key mediator of retinal ganglion cell death. - Test2 - elhamkhani - TriplyDB

Functional genomic screening identifies dual leucine zipper kinase as a key mediator of retinal ganglion cell death.

Functional genomic screening identifies dual leucine zipper kinase as a key mediator of retinal ganglion cell death.

http://www.wikidata.org/entity/Q36673015

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Stem cells, retinal ganglion cells and glaucoma The DLK signalling pathway--a double-edged sword in neural development and regeneration Differentiation of human ESCs to retinal ganglion cells using a CRISPR engineered reporter cell line Elevated intracranial pressure causes optic nerve and retinal ganglion cell degeneration in mice.Losartan Treatment Protects Retinal Ganglion Cells and Alters Scleral Remodeling in Experimental Glaucoma ZPK/DLK and MKK4 form the critical gateway to axotomy-induced motoneuron death in neonates Neuronal Stress Pathway Mediating a Histone Methyl/Phospho Switch Is Required for Herpes Simplex Virus Reactivation.Photoreceptor Outer Segment-like Structures in Long-Term 3D Retinas from Human Pluripotent Stem Cells Dual leucine zipper kinase-dependent PERK activation contributes to neuronal degeneration following insult.SkpA restrains synaptic terminal growth during development and promotes axonal degeneration following injury Differential gene expression in glaucoma DLK-dependent signaling is important for somal but not axonal degeneration of retinal ganglion cells following axonal injury Molecular mechanisms of the suppression of axon regeneration by KLF transcription factors.Chemical genomics for studying parasite gene function and interaction.Cytoskeletal disruption activates the DLK/JNK pathway, which promotes axonal regeneration and mimics a preconditioning injury.Neuroprotective role of Nrf2 for retinal ganglion cells in ischemia-reperfusion.Akt suppresses DLK for maintaining self-renewal of mouse embryonic stem cells.Use of a Machine Learning-Based High Content Analysis Approach to Identify Photoreceptor Neurite Promoting Molecules.The Potential of Human Stem Cells for the Study and Treatment of Glaucoma.Discovery of novel inhibitors for the treatment of glaucoma.Phenotypic Screening of Small-Molecule Inhibitors: Implications for Therapeutic Discovery and Drug Target Development in Traumatic Brain Injury.A mouse ocular explant model that enables the study of living optic nerve head events after acute and chronic intraocular pressure elevation: Focusing on retinal ganglion cell axons and mitochondria.Nrf2 in ischemic neurons promotes retinal vascular regeneration through regulation of semaphorin 6A.Enhanced Functional Genomic Screening Identifies Novel Mediators of Dual Leucine Zipper Kinase-Dependent Injury Signaling in Neurons.Palmitoylation controls DLK localization, interactions and activity to ensure effective axonal injury signaling.DLK initiates a transcriptional program that couples apoptotic and regenerative responses to axonal injury.In vitro and in vivo neuroprotective effects of cJun N-terminal kinase inhibitors on retinal ganglion cells.Treatment Paradigms for Retinal and Macular Diseases Using 3-D Retina Cultures Derived From Human Reporter Pluripotent Stem Cell Lines.Rescue of Glaucomatous Neurodegeneration by Differentially Modulating Neuronal Endoplasmic Reticulum Stress Molecules.An evolutionarily conserved mechanism for cAMP elicited axonal regeneration involves direct activation of the dual leucine zipper kinase DLK Independent pathways downstream of the Wnd/DLK MAPKKK regulate synaptic structure, axonal transport, and injury signaling JNK-mediated phosphorylation of DLK suppresses its ubiquitination to promote neuronal apoptosis.Leucine Zipper-bearing Kinase promotes axon growth in mammalian central nervous system neurons.Loss of the spectraplakin short stop activates the DLK injury response pathway in Drosophila.Mobile zinc increases rapidly in the retina after optic nerve injury and regulates ganglion cell survival and optic nerve regeneration.Spatial and temporal dynamics of neurite regrowth.Dual leucine zipper kinase as a therapeutic target for neurodegenerative conditions.A rapid and sensitive automated image-based approach for in vitro and in vivo characterization of cell morphology and quantification of cell number and neurite architecture.Axon plasticity in the mammalian central nervous system after injury.Dual leucine zipper kinase regulates expression of axon guidance genes in mouse neuronal cells.

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Functional genomic screening identifies dual leucine zipper kinase as a key mediator of retinal ganglion cell death.

http://www.wikidata.org/entity/Q36673015

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Functional genomic screening i ...... f retinal ganglion cell death.

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Proceedings of the National Academy of Sciences of the United States of America

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Functional genomic screening i ...... f retinal ganglion cell death.

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Aaron DiAntonio

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Bing Han

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Caroline Simard-Bisson

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Chung-ha O Davis

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Cynthia A Berlinicke

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Derek S Welsbie

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Donald J Zack

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Douglas Auld

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Harry A Quigley

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James Inglese

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P2860

JNK1: a protein kinase stimulated by UV light and Ha-Ras that binds and phosphorylates the c-Jun activation domain

The requirement for Phr1 in CNS axon tract formation reveals the corticostriatal boundary as a choice point for cortical axons

Mitogen-activated protein kinase kinase 7 is an activator of the c-Jun NH2-terminal kinase

The number of people with glaucoma worldwide in 2010 and 2020

High-content chemical and RNAi screens for suppressors of neurotoxicity in a Huntington's disease model

The mixed lineage kinase DLK utilizes MKK7 and not MKK4 as substrate

A quantitative analysis of kinase inhibitor selectivity

The jun proto-oncogene is positively autoregulated by its product, Jun/AP-1

DAPK1 interaction with NMDA receptor NR2B subunits mediates brain damage in stroke

High-throughput screening in primary neurons

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110

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