The mixed lineage kinase DLK utilizes MKK7 and not MKK4 as substrate
about
The kinase activation loop is the key to mixed lineage kinase-3 activation via both autophosphorylation and hematopoietic progenitor kinase 1 phosphorylationScaffold role of a mitogen-activated protein kinase phosphatase, SKRP1, for the JNK signaling pathwaySiah1 interacts with the scaffold protein POSH to promote JNK activation and apoptosisThe MLK family mediates c-Jun N-terminal kinase activation in neuronal apoptosisSynergistic interaction of MEK kinase 2, c-Jun N-terminal kinase (JNK) kinase 2, and JNK1 results in efficient and specific JNK1 activationFibroblast growth factor homologous factors are intracellular signaling proteinsRole of MEKK2-MEK5 in the regulation of TNF-alpha gene expression and MEKK2-MKK7 in the activation of c-Jun N-terminal kinase in mast cellsControl of a kinesin-cargo linkage mechanism by JNK pathway kinasesGrowth cone MKK7 mRNA targeting regulates MAP1b-dependent microtubule bundling to control neurite elongationThe mixed lineage kinase DLK is oligomerized by tissue transglutaminase during apoptosisFyn binds to and phosphorylates the kidney slit diaphragm component NephrinRecruitment of JNK to JIP1 and JNK-dependent JIP1 phosphorylation regulates JNK module dynamics and activationNegative regulation of mixed lineage kinase 3 by protein kinase B/AKT leads to cell survivalThe mitogen-activated protein kinase kinase kinase dual leucine zipper-bearing kinase (DLK) acts as a key regulator of keratinocyte terminal differentiationMixed lineage kinase-dependent JNK activation is governed by interactions of scaffold protein JIP with MAPK module components.Activated mitogen-activated protein kinase kinase 7 redistributes to the cytosol and binds to Jun N-terminal kinase-interacting protein 1 involving oxidative stress during early reperfusion in rat hippocampal CA1 regionZPK/DLK and MKK4 form the critical gateway to axotomy-induced motoneuron death in neonatesRegulation of mixed-lineage kinase activation in JNK-dependent morphogenesis.Autoinhibition of mixed lineage kinase 3 through its Src homology 3 domain.Evidence that 12-lipoxygenase product 12-hydroxyeicosatetraenoic acid activates p21-activated kinase.Role of MLK3 in the regulation of mitogen-activated protein kinase signaling cascades.Transcriptional regulation of mixed lineage kinase 3 by estrogen and its implication in ER-positive breast cancer pathogenesisMixed-lineage kinase control of JNK and p38 MAPK pathways.Ras-MAP kinase signaling pathways and control of cell proliferation: relevance to cancer therapy.Activation of the JNK pathway during dorsal closure in Drosophila requires the mixed lineage kinase, slipper.Genetic analysis of slipper/mixed lineage kinase reveals requirements in multiple Jun-N-terminal kinase-dependent morphogenetic events during Drosophila development.Akt suppresses DLK for maintaining self-renewal of mouse embryonic stem cells.Wallenda regulates JNK-mediated cell death in Drosophila.Palmitoylation controls DLK localization, interactions and activity to ensure effective axonal injury signaling.Functional genomic screening identifies dual leucine zipper kinase as a key mediator of retinal ganglion cell death.Mixed lineage kinases (MLKs): a role in dendritic cells, inflammation and immunity?Pin1-dependent prolyl isomerization modulates the stress-induced phosphorylation of high molecular weight neurofilament protein.An evolutionarily conserved mechanism for cAMP elicited axonal regeneration involves direct activation of the dual leucine zipper kinase DLKLeucine Zipper-bearing Kinase promotes axon growth in mammalian central nervous system neurons.Inhibition of human insulin gene transcription and MafA transcriptional activity by the dual leucine zipper kinaseMixed Lineage Kinase-c-Jun N-Terminal Kinase Axis: A Potential Therapeutic Target in Cancer.Dual leucine zipper kinase as a therapeutic target for neurodegenerative conditions.Protein phosphatases in pancreatic islets.ApoE2, ApoE3, and ApoE4 Differentially Stimulate APP Transcription and Aβ Secretion.Inhibition of mixed-lineage kinase (MLK) activity during G2-phase disrupts microtubule formation and mitotic progression in HeLa cells.
P2860
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P2860
The mixed lineage kinase DLK utilizes MKK7 and not MKK4 as substrate
description
1999 թուականի Ապրիլին հրատարակուած գիտական յօդուած
@hyw
1999 թվականի ապրիլին հրատարակված գիտական հոդված
@hy
article publié dans la revue scientifique Journal of Biological Chemistry
@fr
artículu científicu espublizáu en 1999
@ast
im April 1999 veröffentlichter wissenschaftlicher Artikel
@de
scientific article (publication date: 9 April 1999)
@en
vedecký článok (publikovaný 1999/04/09)
@sk
vědecký článek publikovaný v roce 1999
@cs
wetenschappelijk artikel (gepubliceerd op 1999/04/09)
@nl
наукова стаття, опублікована у квітні 1999
@uk
name
The mixed lineage kinase DLK utilizes MKK7 and not MKK4 as substrate
@ast
The mixed lineage kinase DLK utilizes MKK7 and not MKK4 as substrate
@en
The mixed lineage kinase DLK utilizes MKK7 and not MKK4 as substrate
@nl
type
label
The mixed lineage kinase DLK utilizes MKK7 and not MKK4 as substrate
@ast
The mixed lineage kinase DLK utilizes MKK7 and not MKK4 as substrate
@en
The mixed lineage kinase DLK utilizes MKK7 and not MKK4 as substrate
@nl
prefLabel
The mixed lineage kinase DLK utilizes MKK7 and not MKK4 as substrate
@ast
The mixed lineage kinase DLK utilizes MKK7 and not MKK4 as substrate
@en
The mixed lineage kinase DLK utilizes MKK7 and not MKK4 as substrate
@nl
P2093
P2860
P3181
P356
P1476
The mixed lineage kinase DLK utilizes MKK7 and not MKK4 as substrate
@en
P2093
P2860
P304
P3181
P356
10.1074/JBC.274.15.10195
P407
P577
1999-04-09T00:00:00Z