MCAK associates with the tips of polymerizing microtubules - Test2 - elhamkhani - TriplyDB

MCAK associates with the tips of polymerizing microtubules

MCAK associates with the tips of polymerizing microtubules

http://www.wikidata.org/entity/Q24678365

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TIP150 interacts with and targets MCAK at the microtubule plus ends Regulation of localization and activity of the microtubule depolymerase MCAK The kinesin-8 motor Kif18A suppresses kinetochore movements to control mitotic chromosome alignment The kinesin-13 proteins Kif2a, Kif2b, and Kif2c/MCAK have distinct roles during mitosis in human cells.Examination of actin and microtubule dependent APC localisations in living mammalian cells.+TIPs: SxIPping along microtubule ends Divergent microtubule assembly rates after short- versus long-term loss of end-modulating kinesins.The far C-terminus of MCAK regulates its conformation and spindle pole focusing.TTBK2 with EB1/3 regulates microtubule dynamics in migrating cells through KIF2A phosphorylation Plus end-specific depolymerase activity of Kip3, a kinesin-8 protein, explains its role in positioning the yeast mitotic spindle.Lateral to end-on conversion of chromosome-microtubule attachment requires kinesins CENP-E and MCAK Tubulin tyrosination is a major factor affecting the recruitment of CAP-Gly proteins at microtubule plus ends.The expanded Kinesin-13 repertoire of trypanosomes contains only one mitotic Kinesin indicating multiple extra-nuclear roles Aurora B phosphorylates multiple sites on mitotic centromere-associated kinesin to spatially and temporally regulate its function Deciphering protein function during mitosis in PtK cells using RNAi.Paxillin-dependent stimulation of microtubule catastrophes at focal adhesion sites.Phosphatidylinositol 4-phosphate 5-kinase alpha (PIPKα) regulates neuronal microtubule depolymerase kinesin, KIF2A and suppresses elongation of axon branches.Multisite phosphorylation disrupts arginine-glutamate salt bridge networks required for binding of cytoplasmic linker-associated protein 2 (CLASP2) to end-binding protein 1 (EB1).Aurora B spatially regulates EB3 phosphorylation to coordinate daughter cell adhesion with cytokinesis.Automated tracking of mitotic spindle pole positions shows that LGN is required for spindle rotation but not orientation maintenance.Aurora B inhibits MCAK activity through a phosphoconformational switch that reduces microtubule association Rac1 and Aurora A regulate MCAK to polarize microtubule growth in migrating endothelial cells.Probing microtubule polymerisation state at single kinetochores during metaphase chromosome motion Spatial regulation of astral microtubule dynamics by Kif18B in PtK cells.A perikinetochoric ring defined by MCAK and Aurora-B as a novel centromere domain.MCAK is present at centromeres, midspindle and chiasmata and involved in silencing of the spindle assembly checkpoint in mammalian oocytes.Ras regulates kinesin 13 family members to control cell migration pathways in transformed human bronchial epithelial cells.MCAK-mediated regulation of endothelial cell microtubule dynamics is mechanosensitive to myosin-II contractility.How kinesin motor proteins drive mitotic spindle function: Lessons from molecular assays.Long astral microtubules uncouple mitotic spindles from the cytokinetic furrow MCAK activity at microtubule tips regulates spindle microtubule length to promote robust kinetochore attachment.Full-length dimeric MCAK is a more efficient microtubule depolymerase than minimal domain monomeric MCAK A unique kinesin-8 surface loop provides specificity for chromosome alignment PLK1 phosphorylates mitotic centromere-associated kinesin and promotes its depolymerase activity Nucleotide exchange in dimeric MCAK induces longitudinal and lateral stress at microtubule ends to support depolymerization.The interplay of the N- and C-terminal domains of MCAK control microtubule depolymerization activity and spindle assembly.Mitotic centromere-associated kinesin (MCAK): a potential cancer drug target.EB1-recruited microtubule +TIP complexes coordinate protrusion dynamics during 3D epithelial remodeling.Cyc17, a meiosis-specific cyclin, is essential for anaphase initiation and chromosome segregation in Tetrahymena thermophila.Signaling Scaffold Protein IQGAP1 Interacts with Microtubule Plus-end Tracking Protein SKAP and Links Dynamic Microtubule Plus-end to Steer Cell Migration.

P2860

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P2860

MCAK associates with the tips of polymerizing microtubules

http://www.wikidata.org/entity/Q24678365

description

2005 nî lūn-bûn

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2005 թուականի Մայիսին հրատարակուած գիտական յօդուած

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2005 թվականի մայիսին հրատարակված գիտական հոդված

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2005年の論文

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2005年論文

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2005年論文

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2005年論文

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2005年論文

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2005年论文

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name

MCAK associates with the tips of polymerizing microtubules

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MCAK associates with the tips of polymerizing microtubules

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MCAK associates with the tips of polymerizing microtubules

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type

label

MCAK associates with the tips of polymerizing microtubules

@ast

MCAK associates with the tips of polymerizing microtubules

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MCAK associates with the tips of polymerizing microtubules

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prefLabel

MCAK associates with the tips of polymerizing microtubules

@ast

MCAK associates with the tips of polymerizing microtubules

@en

MCAK associates with the tips of polymerizing microtubules

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Journal of Cell Biology

P1476

MCAK associates with the tips of polymerizing microtubules

@en

P2093

Ayana T Moore

http://www.w3.org/2001/XMLSchema#string

Didier Job

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George von Dassow

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Kathleen E Rankin

http://www.w3.org/2001/XMLSchema#string

Leticia Peris

http://www.w3.org/2001/XMLSchema#string

Michael Wagenbach

http://www.w3.org/2001/XMLSchema#string

Yulia Ovechkina

http://www.w3.org/2001/XMLSchema#string

P2860

Aurora B regulates MCAK at the mitotic centromere

Mitotic centromere-associated kinesin is important for anaphase chromosome segregation

A standardized kinesin nomenclature

The KinI kinesin Kif2a is required for bipolar spindle assembly through a functional relationship with MCAK

Dynein/dynactin regulate metaphase spindle length by targeting depolymerizing activities to spindle poles.

A common mechanism for microtubule destabilizers-M type kinesins stabilize curling of the protofilament using the class-specific neck and loops

The offloading model for dynein function: differential function of motor subunits

Two mitotic kinesins cooperate to drive sister chromatid separation during anaphase

MCAK, a Kin I kinesin, increases the catastrophe frequency of steady-state HeLa cell microtubules in an ATP-dependent manner in vitro

Aurora B phosphorylates centromeric MCAK and regulates its localization and microtubule depolymerization activity.

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391-7

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3907241

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10.1083/JCB.200411089

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3

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169

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7858303

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15883193

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2171944

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