Loss of miRNA biogenesis induces p19Arf-p53 signaling and senescence in primary cells. - Test2 - elhamkhani - TriplyDB

Loss of miRNA biogenesis induces p19Arf-p53 signaling and senescence in primary cells.

Loss of miRNA biogenesis induces p19Arf-p53 signaling and senescence in primary cells.

http://www.wikidata.org/entity/Q36741276

about

The tumor suppressors p53, p63, and p73 are regulators of microRNA processing complex MicroRNA control of ovarian function The role of dicer in DNA damage repair MicroRNAs miR-146a/b negatively modulate the senescence-associated inflammatory mediators IL-6 and IL-8 Small silencing RNAs: an expanding universe MicroRNAs are indispensable for reprogramming mouse embryonic fibroblasts into induced stem cell-like cells Sequencing and characterisation of an extensive Atlantic salmon (Salmo salar L.) microRNA repertoire Control by a hair's breadth: the role of microRNAs in the skin Activation of Wnt/β-catenin signaling by lithium chloride attenuates d-galactose-induced neurodegeneration in the auditory cortex of a rat model of aging.MicroRNAs in adipogenesis and as therapeutic targets for obesity.Higher-order unfolding of satellite heterochromatin is a consistent and early event in cell senescence Identification of small molecules that suppress microRNA function and reverse tumorigenesis.Coupling transcriptional and post-transcriptional miRNA regulation in the control of cell fate.Oxygen sufficiency controls TOP mRNA translation via the TSC-Rheb-mTOR pathway in a 4E-BP-independent manner.Dicer inactivation in osteoprogenitor cells compromises fetal survival and bone formation, while excision in differentiated osteoblasts increases bone mass in the adult mouse.p16INK4a and its regulator miR-24 link senescence and chondrocyte terminal differentiation-associated matrix remodeling in osteoarthritis.Smooth muscle miRNAs are critical for post-natal regulation of blood pressure and vascular function.Inactivation of p53 is insufficient to allow B cells and B-cell lymphomas to survive without Dicer.Modulation of inflammatory markers by miR-146a during replicative senescence in trabecular meshwork cells.RNA-ligase-dependent biases in miRNA representation in deep-sequenced small RNA cDNA libraries.MicroRNA profiling in human diploid fibroblasts uncovers miR-519 role in replicative senescence.MicroRNA regulation of ionizing radiation-induced premature senescence.Absence of DICER in monocytes and its regulation by HIV-1.Dicer's role as an antiviral: still an enigma.Dicer ablation impairs prostate stem cell activity and causes prostate atrophy.Tumor suppressor p53 meets microRNAs.Paradoxical microRNAs: individual gene repressors, global translation enhancers MicroRegulators come of age in senescence.Can microRNAs control vascular smooth muscle phenotypic modulation and the response to injury?Altered expression of microRNA-203 in rheumatoid arthritis synovial fibroblasts and its role in fibroblast activation.Role of Dicer in female fertility.Analysis of microRNA turnover in mammalian cells following Dicer1 ablation.Dicer cooperates with p53 to suppress DNA damage and skin carcinogenesis in mice.Reassessment of the role of TSC, mTORC1 and microRNAs in amino acids-meditated translational control of TOP mRNAs.MicroRNA changes in human arterial endothelial cells with senescence: relation to apoptosis, eNOS and inflammation.Identification of microRNAs associated with sexual maturity in rainbow trout brain and testis through small RNA deep sequencing.Posttranscriptional regulation of miRNAs in the DNA damage response.MicroRNAs and their roles in aging.Smg6/Est1 licenses embryonic stem cell differentiation via nonsense-mediated mRNA decay.An essential role for Dicer in adipocyte differentiation.

P2860

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P2860

Loss of miRNA biogenesis induces p19Arf-p53 signaling and senescence in primary cells.

http://www.wikidata.org/entity/Q36741276

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2008年论文

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name

Loss of miRNA biogenesis induces p19Arf-p53 signaling and senescence in primary cells.

@ast

Loss of miRNA biogenesis induces p19Arf-p53 signaling and senescence in primary cells.

@en

type

label

Loss of miRNA biogenesis induces p19Arf-p53 signaling and senescence in primary cells.

@ast

Loss of miRNA biogenesis induces p19Arf-p53 signaling and senescence in primary cells.

@en

prefLabel

Loss of miRNA biogenesis induces p19Arf-p53 signaling and senescence in primary cells.

@ast

Loss of miRNA biogenesis induces p19Arf-p53 signaling and senescence in primary cells.

@en

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Loss of miRNA biogenesis induces p19Arf-p53 signaling and senescence in primary cells.

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P2093

Anthony N Imbalzano

http://www.w3.org/2001/XMLSchema#string

Christine M Eischen

http://www.w3.org/2001/XMLSchema#string

Gyorgy Hutvagner

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Jeanne B Lawrence

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Lisa L Hall

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Rajini Mudhasani

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Stephen Lyle

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Stephen N Jones

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Zhiqing Zhu

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P2860

The RNaseIII enzyme Dicer is required for morphogenesis but not patterning of the vertebrate limb.

A microRNA expression signature of human solid tumors defines cancer gene targets

A biomarker that identifies senescent human cells in culture and in aging skin in vivo

Widespread microRNA repression by Myc contributes to tumorigenesis

Crucial role of p53-dependent cellular senescence in suppression of Pten-deficient tumorigenesis

RAS is regulated by the let-7 microRNA family

A microRNA component of the p53 tumour suppressor network

Dicer function is essential for lung epithelium morphogenesis.

Dicer is essential for mouse development

The miRNA-processing enzyme dicer is essential for the morphogenesis and maintenance of hair follicles

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10.1083/JCB.200802105

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7

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181

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18591425

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