PD-1 promotes immune exhaustion by inducing antiviral T cell motility paralysis
about
Molecular and cellular insights into T cell exhaustionOvercoming T cell exhaustion in infection and cancerTherapeutic antiviral T cells noncytopathically clear persistently infected microglia after conversion into antigen-presenting cellsTuning of antigen sensitivity by T cell receptor-dependent negative feedback controls T cell effector function in inflamed tissues.Real-Time Imaging of Resident T Cells in Human Lung and Ovarian Carcinomas Reveals How Different Tumor Microenvironments Control T Lymphocyte MigrationCCR7 and IRF4-dependent dendritic cells regulate lymphatic collecting vessel permeability.The kinematics of cytotoxic lymphocytes influence their ability to kill target cellsIndividual Motile CD4(+) T Cells Can Participate in Efficient Multikilling through Conjugation to Multiple Tumor Cells.Innate and Adaptive Immune Regulation During Chronic Viral InfectionsThe Next Immune-Checkpoint Inhibitors: PD-1/PD-L1 Blockade in MelanomaCharacteristics and critical function of CD8+ T cells in the Toxoplasma-infected brain.Development of an immunologically tolerated combination of fluorescent proteins for in vivo two-photon imaging.Type I interferon suppresses virus-specific B cell responses by modulating CD8(+) T cell differentiationBiosafety Level 3 setup for multiphoton microscopy in vivo.T cell progenitor therapy-facilitated thymopoiesis depends upon thymic input and continued thymic microenvironment interaction.CD4/CD8/Dendritic cell complexes in the spleen: CD8+ T cells can directly bind CD4+ T cells and modulate their responseGlycogen Synthase Kinase 3 Inactivation Drives T-bet-Mediated Downregulation of Co-receptor PD-1 to Enhance CD8(+) Cytolytic T Cell Responses.Epithelial CaSR deficiency alters intestinal integrity and promotes proinflammatory immune responses.The transcription factor FoxO1 sustains expression of the inhibitory receptor PD-1 and survival of antiviral CD8(+) T cells during chronic infectionCombination of alphavirus replicon particle-based vaccination with immunomodulatory antibodies: therapeutic activity in the B16 melanoma mouse model and immune correlates.Neuroblastoma killing properties of Vδ2 and Vδ2-negative γδT cells following expansion by artificial antigen-presenting cells.PD-L1 Expression on Retrovirus-Infected Cells Mediates Immune Escape from CD8+ T Cell KillingGenetic absence of PD-1 promotes accumulation of terminally differentiated exhausted CD8+ T cellsTransgenic 4-1BBL-engineered vaccine stimulates potent Gag-specific therapeutic and long-term immunity via increased priming of CD44(+)CD62L(high) IL-7R(+) CTLs with up- and downregulation of anti- and pro-apoptosis genes.Mechanisms of PD-L1/PD-1-mediated CD8 T-cell dysfunction in the context of aging-related immune defects in the Eµ-TCL1 CLL mouse model.Type I and Type II Interferon Coordinately Regulate Suppressive Dendritic Cell Fate and Function during Viral PersistenceA Plasmodium Promiscuous T Cell Epitope Delivered within the Ad5 Hexon Protein Enhances the Protective Efficacy of a Protein Based Malaria VaccineSignaling pathway and dysregulation of PD1 and its ligands in lymphoid malignancies.AMPK Is Essential to Balance Glycolysis and Mitochondrial Metabolism to Control T-ALL Cell Stress and Survival.PSGL-1 Is an Immune Checkpoint Regulator that Promotes T Cell Exhaustion.The great balancing act: regulation and fate of antiviral T-cell interactionsElevated Expression of Programmed Death-1 and Programmed Death Ligand-1 Negatively Regulates Immune Response against Cervical Cancer CellsProgramed death-1/programed death-ligand 1 expression in lymph nodes of HIV infected patients: results of a pilot safety study in rhesus macaques using anti-programed death-ligand 1 (Avelumab).PD-L1 blockade attenuated sepsis-induced liver injury in a mouse cecal ligation and puncture model.Exploiting apoptosis for therapeutic tolerance induction.Detection of Foreign Antigen-specific CD4(+)Foxp3(+) Regulatory T Cells by MHC Class II Tetramer and Intracellular CD154 Staining.Tumour-infiltrating lymphocytes predict response to definitive chemoradiotherapy in head and neck cancer.Imaging CD8+ T cells during diverse viral infections.Negative regulation by PD-L1 during drug-specific priming of IL-22-secreting T cells and the influence of PD-1 on effector T cell function.The new normal: immunomodulatory agents against sepsis immune suppression.
P2860
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P2860
PD-1 promotes immune exhaustion by inducing antiviral T cell motility paralysis
description
2013 nî lūn-bûn
@nan
2013年の論文
@ja
2013年論文
@yue
2013年論文
@zh-hant
2013年論文
@zh-hk
2013年論文
@zh-mo
2013年論文
@zh-tw
2013年论文
@wuu
2013年论文
@zh
2013年论文
@zh-cn
name
PD-1 promotes immune exhaustion by inducing antiviral T cell motility paralysis
@en
type
label
PD-1 promotes immune exhaustion by inducing antiviral T cell motility paralysis
@en
prefLabel
PD-1 promotes immune exhaustion by inducing antiviral T cell motility paralysis
@en
P2093
P2860
P50
P356
P1476
PD-1 promotes immune exhaustion by inducing antiviral T cell motility paralysis
@en
P2093
Catarina Sacristán
Jasmin Herz
Sara Heydari
Simon J Davis
Xiaoxiao Cheng
P2860
P304
P356
10.1084/JEM.20121416
P407
P577
2013-03-25T00:00:00Z