about
Generation of recombinant lymphocytic choriomeningitis viruses with trisegmented genomes stably expressing two additional genes of interestIlluminating viral infections in the nervous systemMicroglia development and functionType I interferon programs innate myeloid dynamics and gene expression in the virally infected nervous systemInflammation and neuroprotection in traumatic brain injuryInterleukin-10 determines viral clearance or persistence in vivoScrapie-induced defects in learning and memory of transgenic mice expressing anchorless prion protein are associated with alterations in the gamma aminobutyric acid-ergic pathway.MRI confirms loss of blood-brain barrier integrity in a mouse model of disseminated candidiasisIn vivo dynamics of innate immune sentinels in the CNS.Transcranial amelioration of inflammation and cell death after brain injury.Development of an immunologically tolerated combination of fluorescent proteins for in vivo two-photon imaging.Intradiabodies, bispecific, tetravalent antibodies for the simultaneous functional knockout of two cell surface receptors.Quantitative assessment of neurologic deficits in a chronic progressive murine model of CNS demyelination.A role for humoral mechanisms in the pathogenesis of Devic's neuromyelitis optica.Absence of spontaneous central nervous system remyelination in class II-deficient mice infected with Theiler's virus.HLA-DQ polymorphism influences progression of demyelination and neurologic deficits in a viral model of multiple sclerosisOptimizing multiphoton fluorescence microscopy light collection from living tissue by noncontact total emission detection (epiTED).Intrinsic functional dysregulation of CD4 T cells occurs rapidly following persistent viral infectionA little 'help' from IL-21 during persistent viral infectionMolecular anatomy and number of antigen specific CD8 T cells required to cause type 1 diabetesReprogramming of antiviral T cells prevents inactivation and restores T cell activity during persistent viral infectionT cells in the central nervous system: the delicate balance between viral clearance and diseaseAltered central nervous system gene expression caused by congenitally acquired persistent infection with lymphocytic choriomeningitis virus.Migration of cytotoxic lymphocytes in cell cycle permits local MHC I-dependent control of division at sites of viral infectionSystemic inflammation in early neonatal mice induces transient and lasting neurodegenerative effects.Quantitative ultrastructural analysis of a single spinal cord demyelinated lesion predicts total lesion load, axonal loss, and neurological dysfunction in a murine model of multiple sclerosisClearance of an immunosuppressive virus from the CNS coincides with immune reanimation and diversification.Adoptive immunotherapy induces CNS dendritic cell recruitment and antigen presentation during clearance of a persistent viral infectionImmunotherapeutic relief from persistent infections and amyloid disorders.Molecular analysis of the interaction of LCMV with its cellular receptor [alpha]-dystroglycan.IL-10 blockade facilitates DNA vaccine-induced T cell responses and enhances clearance of persistent virus infection.PD-1 promotes immune exhaustion by inducing antiviral T cell motility paralysisA novel virus carrier state to evaluate immunotherapeutic regimens: regulatory T cells modulate the pathogenicity of antiviral memory cellsInflammation on the mind: visualizing immunity in the central nervous system.Myelomonocytic cell recruitment causes fatal CNS vascular injury during acute viral meningitis.Therapeutic memory T cells require costimulation for effective clearance of a persistent viral infection.Absence of neurological deficits following extensive demyelination in a class I-deficient murine model of multiple sclerosisCellular sources and targets of IFN-gamma-mediated protection against viral demyelination and neurological deficits.Rebuilding an immune-mediated central nervous system disease: weighing the pathogenicity of antigen-specific versus bystander T cells.Primary demyelination in transgenic mice expressing interferon-gamma
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description
hulumtues
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researcher
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wetenschapper
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հետազոտող
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name
Dorian B McGavern
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Dorian B McGavern
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Dorian B McGavern
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Dorian B McGavern
@nl
Dorian B McGavern
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type
label
Dorian B McGavern
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Dorian B McGavern
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Dorian B McGavern
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Dorian B McGavern
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Dorian B McGavern
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prefLabel
Dorian B McGavern
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Dorian B McGavern
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Dorian B McGavern
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Dorian B McGavern
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Dorian B McGavern
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0000-0001-9568-545X