Mutation is required to activate the p53 gene for cooperation with the ras oncogene and transformation.
about
Transcriptional activation by wild-type but not transforming mutants of the p53 anti-oncogeneHuman TAFII31 protein is a transcriptional coactivator of the p53 proteinSIRT3 regulates progression and development of diseases of aging.Uncovering the role of p53 splice variants in human malignancy: a clinical perspectiveHuman papillomavirus E6 proteins bind p53 in vivo and abrogate p53-mediated repression of transcriptionIdentification of rCop-1, a new member of the CCN protein family, as a negative regulator for cell transformationWild-type p53 can inhibit oncogene-mediated focus formationMolecular genetics of neurological tumoursMolecular mechanisms of cancer.Chromosome 17p deletions and p53 gene mutations associated with the formation of malignant neurofibrosarcomas in von Recklinghausen neurofibromatosis.Complex formation of human papillomavirus E7 proteins with the retinoblastoma tumor suppressor gene product.Mechanisms of p53 loss in human sarcomas.Evidence of a role for phosphatidylinositol 3-kinase activation in the blocking of apoptosis by polyomavirus middle T antigen.p53-mediated repression of alpha-fetoprotein gene expression by specific DNA binding.Wild-type, but not mutant, human p53 proteins inhibit the replication activities of simian virus 40 large tumor antigen.Env-derived gp55 gene of Friend spleen focus-forming virus specifically induces neoplastic proliferation of erythroid progenitor cells.Frequent mutation of the p53 gene in human esophageal cancerProperties of p53 mutations detected in primary and secondary cervical cancers suggest mechanisms of metastasis and involvement of environmental carcinogens.The transcriptional transactivation function of wild-type p53 is inhibited by SV40 large T-antigen and by HPV-16 E6 oncoprotein.The transforming and suppressor functions of p53 alleles: effects of mutations that disrupt phosphorylation, oligomerization and nuclear translocation.An apoptotic defect in lens differentiation caused by human p53 is rescued by a mutant alleleQuantitation of G0 and G1 phase cells in primary carcinomas. Antibody to M1 subunit of ribonucleotide reductase shows G1 phase restriction point block.p53 functions as a cell cycle control protein in osteosarcomasIdentification of intronic point mutations as an alternative mechanism for p53 inactivation in lung cancer.Epstein-Barr virus/complement fragment C3d receptor (CR2) reacts with p53, a cellular antioncogene-encoded membrane phosphoprotein: detection by polyclonal anti-idiotypic anti-CR2 antibodies.Expression of mutant p53 protein in hepatocellular carcinoma.Oncogenes and tumor-suppressor genes.Abrogation of oncogene-associated apoptosis allows transformation of p53-deficient cells.p53 and E2F-1 cooperate to mediate apoptosis.Hereditary and acquired p53 gene mutations in childhood acute lymphoblastic leukemiaAbsence of hereditary p53 mutations in 10 familial leukemia pedigrees.Widespread p53 overexpression in human malignant tumors. An immunohistochemical study using methacarn-fixed, embedded tissue.Mutational spectrum of the p53 gene in human small-cell lung cancer and relationship to clinicopathological data.Concurrent p53 expression in bronchial dysplasias and squamous cell lung carcinomas.Pancreatic adenocarcinomas frequently show p53 gene mutations.Detection of K-ras mutations in mucinous pancreatic duct hyperplasia from a patient with a family history of pancreatic carcinoma.Gain-of-function mutations of the p53 gene induce lymphohematopoietic metastatic potential and tissue invasiveness.The prognostic significance of the accumulation of p53 tumour-suppressor gene protein in gastric adenocarcinoma.p53 mutations and overexpression in locally advanced breast cancersp53 in colorectal cancer: clinicopathological correlation and prognostic significance.
P2860
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P2860
Mutation is required to activate the p53 gene for cooperation with the ras oncogene and transformation.
description
1989 nî lūn-bûn
@nan
1989年の論文
@ja
1989年論文
@yue
1989年論文
@zh-hant
1989年論文
@zh-hk
1989年論文
@zh-mo
1989年論文
@zh-tw
1989年论文
@wuu
1989年论文
@zh
1989年论文
@zh-cn
name
Mutation is required to activa ...... s oncogene and transformation.
@ast
Mutation is required to activa ...... s oncogene and transformation.
@en
type
label
Mutation is required to activa ...... s oncogene and transformation.
@ast
Mutation is required to activa ...... s oncogene and transformation.
@en
prefLabel
Mutation is required to activa ...... s oncogene and transformation.
@ast
Mutation is required to activa ...... s oncogene and transformation.
@en
P2093
P2860
P1433
P1476
Mutation is required to activa ...... s oncogene and transformation.
@en
P2093
P2860
P304
P407
P577
1989-02-01T00:00:00Z