The role of mitochondria in pharmacotoxicology: a reevaluation of an old, newly emerging topic.
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Doxorubicin in vivo rapidly alters expression and translation of myocardial electron transport chain genes, leads to ATP loss and caspase 3 activationA high-throughput screen for mitochondrial function reveals known and novel mitochondrial toxicants in a library of environmental agentsInhibitory Effect of Bridged Nucleosides on Thermus aquaticus DNA Polymerase and Insight into the Binding InteractionsProposal of an in silico profiler for categorisation of repeat dose toxicity data of hair dyes.K(ATP) channels and MPTP are involved in the cardioprotection bestowed by chronic intermittent hypobaric hypoxia in the developing rat.Parallel multiplicative target screening against divergent bacterial replicases: identification of specific inhibitors with broad spectrum potentialImmunohistochemical expression of mitochondrial membrane complexes (MMCs) I, III, IV and V in malignant and benign periampullary epithelium: a potential target for drug therapy of periampullary cancer?NSAIDs, Mitochondria and Calcium Signaling: Special Focus on Aspirin/SalicylatesInhibition of α-KG-dependent histone and DNA demethylases by fumarate and succinate that are accumulated in mutations of FH and SDH tumor suppressorsSe-methylselenocysteine inhibits apoptosis induced by clusterin knockdown in neuroblastoma N2a and SH-SY5Y cell lines.Surface plasmon resonance-induced photoactivation of gold nanoparticles as mitochondria-targeted therapeutic agents for pancreatic cancer.High-throughput screening of FDA-approved drugs using oxygen biosensor plates reveals secondary mitofunctional effects.Design and synthesis of a mitochondria-targeting carrier for small molecule drugs.Influence of caspase-3 silencing on the proliferation and apoptosis of rat bone marrow mesenchymal stem cells under hypoxiaCardiac aging: from molecular mechanisms to significance in human health and diseaseLead optimization of 3-carboxyl-4(1H)-quinolones to deliver orally bioavailable antimalarials.Mitochondrial genome-knockout cells demonstrate a dual mechanism of action for the electron transport complex I inhibitor mycothiazole.Prediction of liver injury induced by chemicals in human with a multiparametric assay on isolated mouse liver mitochondria.Alpinetin inhibits lung cancer progression and elevates sensitization drug-resistant lung cancer cells to cis-diammined dichloridoplatium.DNA polymerases as therapeutic targetsMechanism-based bioanalysis and biomarkers for hepatic chemical stress.Metabolic bioactivation and drug-related adverse effects: current status and future directions from a pharmaceutical research perspective.Exploratory safety pharmacology: a new safety paradigm to de-risk drug candidates prior to selection for regulatory science investigations.Novel therapies targeting inner mitochondrial membrane--from discovery to clinical development.The proteomics of cancer stem cells: potential clinical applications for innovative research in oncology.Mitochondria as a pharmacological target: magnum overview.Rare insights into cancer biology.The effects of acute renal failure on drug metabolism.Pathological mitochondrial copper overload in livers of Wilson's disease patients and related animal models.The Aging HeartAntifungal-Associated Drug-Induced Cardiac Disease.Peroxisome Proliferator-Activated Receptor Ligands and Their Role in Chronic Myeloid Leukemia: Therapeutic Strategies.Mitochondria as targets of drug toxicity: Lessons from the R118 phase I experience.Hepatic Lipodystrophy in Galloway Calves.DNMT1 modulation in chronic hepatitis B patients and hypothetic influence on mitochondrial DNA methylation status during long-term nucleo(t)side analogs therapy.C-Glycosyl Flavonoids from Beta vulgaris Cicla and Betalains from Beta vulgaris rubra: Antioxidant, Anticancer and Antiinflammatory Activities-A Review.Effect of mitochondrial dysfunction and oxidative stress on endogenous levels of coenzyme Q(10) in human cells.Effects and interactions in an environmentally relevant mixture of pharmaceuticals.Mitochondria, PPARs, and Cancer: Is Receptor-Independent Action of PPAR Agonists a Key?Mitochondria sustain store-operated currents in colon cancer cells but not in normal colonic cells: reversal by non-steroidal anti-inflammatory drugs.
P2860
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P2860
The role of mitochondria in pharmacotoxicology: a reevaluation of an old, newly emerging topic.
description
2007 nî lūn-bûn
@nan
2007年の論文
@ja
2007年論文
@yue
2007年論文
@zh-hant
2007年論文
@zh-hk
2007年論文
@zh-mo
2007年論文
@zh-tw
2007年论文
@wuu
2007年论文
@zh
2007年论文
@zh-cn
name
The role of mitochondria in ph ...... an old, newly emerging topic.
@ast
The role of mitochondria in ph ...... an old, newly emerging topic.
@en
type
label
The role of mitochondria in ph ...... an old, newly emerging topic.
@ast
The role of mitochondria in ph ...... an old, newly emerging topic.
@en
prefLabel
The role of mitochondria in ph ...... an old, newly emerging topic.
@ast
The role of mitochondria in ph ...... an old, newly emerging topic.
@en
P2093
P2860
P1476
The role of mitochondria in ph ...... f an old, newly emerging topic
@en
P2093
Bruno Giardina
Giorgia Botta
Giuseppe E Martorana
Roberto Scatena
P2860
P304
P356
10.1152/AJPCELL.00314.2006
P577
2007-05-02T00:00:00Z