Mitochondrial tumour suppressors: a genetic and biochemical update - Test2 - elhamkhani - TriplyDB

Mitochondrial tumour suppressors: a genetic and biochemical update

Mitochondrial tumour suppressors: a genetic and biochemical update

http://www.wikidata.org/entity/Q28285094

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A recurrent stop-codon mutation in succinate dehydrogenase subunit B gene in normal peripheral blood and childhood T-cell acute leukemia Fumarase: a mitochondrial metabolic enzyme and a cytosolic/nuclear component of the DNA damage response Pyruvate dehydrogenase complex activity controls metabolic and malignant phenotype in cancer cells miR-210 is overexpressed in late stages of lung cancer and mediates mitochondrial alterations associated with modulation of HIF-1 activity Lithocholic bile acid selectively kills neuroblastoma cells, while sparing normal neuronal cells Stable isotope-resolved metabolomics and applications for drug development State of the science: an update on renal cell carcinoma Redox-directed cancer therapeutics: molecular mechanisms and opportunities Polymorphisms in mitochondrial genes and prostate cancer risk Cell-permeating alpha-ketoglutarate derivatives alleviate pseudohypoxia in succinate dehydrogenase-deficient cells Fundamentals of cancer metabolism Mitochondrial metabolic remodeling in response to genetic and environmental perturbations Hepatocellular carcinoma: Review of disease and tumor biomarkers A novel approach to the discovery of anti-tumor pharmaceuticals: searching for activators of liponecrosis Dysregulated metabolism contributes to oncogenesis Cancer metabolism: key players in metabolic reprogramming HypoxamiRs and cancer: from biology to targeted therapy Novel therapeutic targets of tumor metabolism Survivin promotes oxidative phosphorylation, subcellular mitochondrial repositioning, and tumor cell invasion IDH mutations in tumorigenesis and their potential role as novel therapeutic targets.Mitochondrial disease: powerhouse of disease Structure-based development of small molecule PFKFB3 inhibitors: a framework for potential cancer therapeutic agents targeting the Warburg effect Tumour suppressor Fus1 provides a molecular link between inflammatory response and mitochondrial homeostasis Dual mode action of mangiferin in mouse liver under high fat diet Mitochondrial metabolism and ROS generation are essential for Kras-mediated tumorigenicity Multiscale models of angiogenesis Angiostatin regulates the expression of antiangiogenic and proapoptotic pathways via targeted inhibition of mitochondrial proteins A neuronal network of mitochondrial dynamics regulates metastasis.Analysis and interpretation of transcriptomic data obtained from extended Warburg effect genes in patients with clear cell renal cell carcinoma.Cytoplasmic signaling in the control of mitochondrial uproar?The genomic analysis of lactic acidosis and acidosis response in human cancers The first Dutch SDHB founder deletion in paraganglioma-pheochromocytoma patients No evidence for promoter region methylation of the succinate dehydrogenase and fumarate hydratase tumour suppressor genes in breast cancer.Immunohistochemical expression of mitochondrial membrane complexes (MMCs) I, III, IV and V in malignant and benign periampullary epithelium: a potential target for drug therapy of periampullary cancer?Succinate-to-fumarate ratio as a new metabolic marker to detect the presence of SDHB/D-related paraganglioma: initial experimental and ex vivo findings.Current views on cell metabolism in SDHx-related pheochromocytoma and paraganglioma Elevated plasma succinate in PTEN, SDHB, and SDHD mutation-positive individuals.Multiplex analysis of mitochondrial DNA pathogenic and polymorphic sequence variants.Is Akt the "Warburg kinase"?-Akt-energy metabolism interactions and oncogenesis.Paragangliomas/Pheochromocytomas: clinically oriented genetic testing

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Mitochondrial tumour suppressors: a genetic and biochemical update

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2005 nî lūn-bûn

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2005年の論文

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Mitochondrial tumour suppressors: a genetic and biochemical update

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Nature Reviews Cancer

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Mitochondrial tumour suppressors: a genetic and biochemical update

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Eyal Gottlieb

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Ian P M Tomlinson

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Disruption of mitochondrial function during apoptosis is mediated by caspase cleavage of the p75 subunit of complex I of the electron transport chain

Mutations in the fumarate hydratase gene cause hereditary leiomyomatosis and renal cell cancer in families in North America

Mitochondrial defects in cancer

A HIF1alpha regulatory loop links hypoxia and mitochondrial signals in pheochromocytomas

Architecture of succinate dehydrogenase and reactive oxygen species generation

Targeting HIF-1 for cancer therapy

The mitochondrial transporter family (SLC25): physiological and pathological implications

A role for mitochondrial enzymes in inherited neoplasia and beyond

Neuronal apoptosis linked to EglN3 prolyl hydroxylase and familial pheochromocytoma genes: developmental culling and cancer

Distinct clinical features of paraganglioma syndromes associated with SDHB and SDHD gene mutations

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10.1038/NRC1737

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