An AT-hook domain in MeCP2 determines the clinical course of Rett syndrome and related disorders.
about
MECP2 disorders: from the clinic to mice and backDNA modifications: function and applications in normal and disease StatesRett syndrome: disruption of epigenetic control of postnatal neurological functionsMice with Shank3 Mutations Associated with ASD and Schizophrenia Display Both Shared and Distinct Defects.A de novo t(10;19)(q22.3;q13.33) leads to ZMIZ1/PRR12 reciprocal fusion transcripts in a girl with intellectual disability and neuropsychiatric alterationsSUMOylation of MeCP2 is essential for transcriptional repression and hippocampal synapse developmentMicroglia contribute to circuit defects in Mecp2 null mice independent of microglia-specific loss of Mecp2 expressionLoss of MeCP2 in Parvalbumin-and Somatostatin-Expressing Neurons in Mice Leads to Distinct Rett Syndrome-like PhenotypesRestoration of Mecp2 expression in GABAergic neurons is sufficient to rescue multiple disease features in a mouse model of Rett syndrome.MeCP2 recognizes cytosine methylated tri-nucleotide and di-nucleotide sequences to tune transcription in the mammalian brain.The Crucial Role of DNA Methylation and MeCP2 in Neuronal FunctionMeCP2 Promotes Gastric Cancer Progression Through Regulating FOXF1/Wnt5a/β-Catenin and MYOD1/Caspase-3 Signaling Pathways.Methyl-CpG binding domain protein 1 regulates localization and activity of Tet1 in a CXXC3 domain-dependent manner.Computational and experimental approaches to reveal the effects of single nucleotide polymorphisms with respect to disease diagnosticsRett-causing mutations reveal two domains critical for MeCP2 function and for toxicity in MECP2 duplication syndrome mice.Maintaining genome stability in the nervous system.Analysis of neonatal brain lacking ATRX or MeCP2 reveals changes in nucleosome density, CTCF binding and chromatin loopingDNA methylation reader MECP2: cell type- and differentiation stage-specific protein distribution.Disruption of DNA-methylation-dependent long gene repression in Rett syndrome.Cell cycle-linked MeCP2 phosphorylation modulates adult neurogenesis involving the Notch signalling pathway.MeCP2 binds to non-CG methylated DNA as neurons mature, influencing transcription and the timing of onset for Rett syndromeAutism spectrum disorders: emerging mechanisms and mechanism-based treatment.Reading the unique DNA methylation landscape of the brain: Non-CpG methylation, hydroxymethylation, and MeCP2.MeCP2 regulates the timing of critical period plasticity that shapes functional connectivity in primary visual cortex.Karyopherin α 3 and karyopherin α 4 proteins mediate the nuclear import of methyl-CpG binding protein 2A high-resolution imaging approach to investigate chromatin architecture in complex tissuesReduction of aberrant NF-κB signalling ameliorates Rett syndrome phenotypes in Mecp2-null mice.MECP2 missense mutations outside the canonical MBD and TRD domains in males with intellectual disability.A critical period of vulnerability to adolescent stress: epigenetic mediators in mesocortical dopaminergic neurons.Sequence features accurately predict genome-wide MeCP2 binding in vivo.De novo truncating variants in the AHDC1 gene encoding the AT-hook DNA-binding motif-containing protein 1 are associated with intellectual disability and developmental delayA/T Run Geometry of B-form DNA Is Independent of Bound Methyl-CpG Binding Domain, Cytosine Methylation and Flanking Sequence.Epigenetics, autism spectrum, and neurodevelopmental disorders.Transcriptional regulation of the MET receptor tyrosine kinase gene by MeCP2 and sex-specific expression in autism and Rett syndrome.Histone deacetylase 3 associates with MeCP2 to regulate FOXO and social behavior.Chromatin context and ncRNA highlight targets of MeCP2 in brain.DNA methylation in the gene body influences MeCP2-mediated gene repression.Human pluripotent stem cell models of autism spectrum disorder: emerging frontiers, opportunities, and challenges towards neuronal networks in a dishDNA methylation and childhood maltreatment: from animal models to human studies.Epigenetics and the regulation of stress vulnerability and resilience.
P2860
Q26799760-EEA40993-F523-4500-ACB1-7B57B1AB8A60Q26829214-60F6D9E1-52B4-4B3D-8EDD-D04CD7491624Q28088283-814BA046-B120-4F7F-8D16-AE36809A4227Q28271310-71B6ED8B-073B-4306-B697-A6098C5E670CQ28771505-44E663E7-6B12-4388-AC13-7E928E2C70DBQ28909718-9D073FC1-EBCA-4517-BF0A-0337DEF57661Q30357465-12C2C11A-3FCE-4C0C-B516-E6E96EE0C42DQ30369619-53BED087-D253-4697-9CBC-4CF8C5EAE28FQ30378674-6962C510-A441-4202-9661-BA80882FCEE4Q33732160-64453DAA-A86B-4D2D-A4FB-FEF2CE8B9595Q33737461-6EDB7FC4-CE32-449E-98D1-545972D920D7Q33809732-24D10048-7B3C-4C29-8E8F-16B2179A3EE9Q33878027-F3A9253D-5519-496E-9F73-1EC2485E73EAQ33907569-71395A74-C81C-4E88-A28A-59DAE9713334Q33915332-48DC2817-CE5C-4DB9-86B8-CDFC8C283129Q33957193-0DCDF42A-DA91-4CAC-B13A-5B6CBB60DA06Q33983659-9F65625C-D63E-4E60-8B72-C589A6D95FD8Q34103956-1B571DD2-BF3D-443B-B627-0401D99C32E1Q34466731-CF4F1DFD-A07E-4281-9962-B64DA31DC1D4Q34890354-96355E03-CC55-4873-9BE7-79CB806B3460Q35566873-6442E162-FAF4-4279-818F-D14F87C3F3DBQ35595728-C8527B5B-0C97-40C3-9731-A2BB3F5B28A2Q35699206-E57B05C1-AF99-46AC-A801-4ABB74D65959Q36008270-8D93E0AA-7603-4DD4-ABC1-FEF8D9997113Q36049921-F06586C1-E6C0-4A1A-A955-D3F991D7AF34Q36094434-B9E502AE-4AF6-452F-9F00-C530EBA7D2B5Q36540413-C423B30D-0A1C-4F43-A102-81782B469CB8Q36628976-8295A78C-35ED-4F2A-B218-5ACBF012434DQ36676822-361A3A95-88FD-4829-A7B0-6C481966CDF0Q36765190-89DF00A7-F4D0-4279-BCB6-DA9CF20D8E00Q36851443-2074436D-ABAF-44F9-872F-DB7779BE7D0CQ37159793-42C2FEC3-23E6-4444-972A-C78378F73315Q37249145-199CC2E1-01F0-4C14-9EE2-DB9FD3815216Q37281126-ABED3D8E-086E-4065-A8FA-FD334A83B8E5Q37372395-DE609BC6-1F51-4561-8C90-A16EAF14803AQ37534398-0DF5503F-BA6A-4D33-A91C-872B7FCC044FQ37550088-37CE2083-967D-4375-85E6-08F1E4171A47Q37598427-404E9E3A-A677-4486-8362-5BC188D7EC8BQ37626764-EB5D9C01-1883-431A-98D5-404FF09BBA7BQ37647937-67C14A0E-484F-4118-A1E8-313C4AB7EFB9
P2860
An AT-hook domain in MeCP2 determines the clinical course of Rett syndrome and related disorders.
description
2013 nî lūn-bûn
@nan
2013年の論文
@ja
2013年論文
@yue
2013年論文
@zh-hant
2013年論文
@zh-hk
2013年論文
@zh-mo
2013年論文
@zh-tw
2013年论文
@wuu
2013年论文
@zh
2013年论文
@zh-cn
name
An AT-hook domain in MeCP2 det ...... yndrome and related disorders.
@ast
An AT-hook domain in MeCP2 det ...... yndrome and related disorders.
@en
type
label
An AT-hook domain in MeCP2 det ...... yndrome and related disorders.
@ast
An AT-hook domain in MeCP2 det ...... yndrome and related disorders.
@en
prefLabel
An AT-hook domain in MeCP2 det ...... yndrome and related disorders.
@ast
An AT-hook domain in MeCP2 det ...... yndrome and related disorders.
@en
P2093
P2860
P1433
P1476
An AT-hook domain in MeCP2 det ...... yndrome and related disorders.
@en
P2093
Angela Dawn Wilkins
Steven Andrew Baker
P2860
P304
P356
10.1016/J.CELL.2013.01.038
P407
P577
2013-02-01T00:00:00Z