NIK overexpression amplifies, whereas ablation of its TRAF3-binding domain replaces BAFF:BAFF-R-mediated survival signals in B cells.
about
Roles of tumor necrosis factor receptor associated factor 3 (TRAF3) and TRAF5 in immune cell functionsSelf-termination of the terminatorInflammation meets cancer, with NF-κB as the matchmakerNon-canonical NF-κB activation and abnormal B cell accumulation in mice expressing ubiquitin protein ligase-inactive c-IAP2.NIK stabilization in osteoclasts results in osteoporosis and enhanced inflammatory osteolysis.Roles of the NF-kappaB pathway in lymphocyte development and function.The noncanonical NF-κB pathway.Negative feedback in noncanonical NF-kappaB signaling modulates NIK stability through IKKalpha-mediated phosphorylationHuman TRAF3 adaptor molecule deficiency leads to impaired Toll-like receptor 3 response and susceptibility to herpes simplex encephalitis.Cleavage of NIK by the API2-MALT1 fusion oncoprotein leads to noncanonical NF-kappaB activationBAFF receptor signaling aids the differentiation of immature B cells into transitional B cells following tonic BCR signalingIκB kinase β (IKBKB) mutations in lymphomas that constitutively activate canonical nuclear factor κB (NFκB) signaling.Constitutive BR3 receptor signaling in diffuse, large B-cell lymphomas stabilizes nuclear factor-κB-inducing kinase while activating both canonical and alternative nuclear factor-κB pathways.Mouse hepatocyte overexpression of NF-κB-inducing kinase (NIK) triggers fatal macrophage-dependent liver injury and fibrosis.Biallelic loss-of-function mutation in NIK causes a primary immunodeficiency with multifaceted aberrant lymphoid immunity.NIK signaling in dendritic cells but not in T cells is required for the development of effector T cells and cell-mediated immune responsesNF-κB in immunobiology.Signaling by the tumor necrosis factor receptor superfamily in B-cell biology and diseaseCarboxyl terminus of HSC70-interacting protein (CHIP) down-regulates NF-κB-inducing kinase (NIK) and suppresses NIK-induced liver injuryNF-κB–inducing kinase plays an essential T cell–intrinsic role in graft-versus-host disease and lethal autoimmunity in miceAn oncogenic role for alternative NF-κB signaling in DLBCL revealed upon deregulated BCL6 expression.AR-regulated TWEAK-FN14 pathway promotes prostate cancer bone metastasisBAFF promotes proliferation of human mesangial cells through interaction with BAFF-RTargeting signaling factors for degradation, an emerging mechanism for TRAF functionsK63-linked ubiquitination in kinase activation and cancer.The coding genome of splenic marginal zone lymphoma: activation of NOTCH2 and other pathways regulating marginal zone development.TNFR-associated factor 2 deficiency in B lymphocytes predisposes to chronic lymphocytic leukemia/small lymphocytic lymphoma in mice.Antagonism of inhibitor of apoptosis proteins increases bone metastasis via unexpected osteoclast activationNF-κB–inducing kinase (NIK) promotes hyperglycemia and glucose intolerance in obesity by augmenting glucagon actionThe immunological contribution of NF-κB within the tumor microenvironment: a potential protective role of zinc as an anti-tumor agent.NF-kappaB p100 limits TNF-induced bone resorption in mice by a TRAF3-dependent mechanism.Murine BAFF-receptor residues 168-175 are essential for optimal CD21/35 expression but dispensable for B cell survival.Context-specific BAFF-R signaling by the NF-κB and PI3K pathwaysTRAF3 regulates the effector function of regulatory T cells and humoral immune responses.Noncanonical NF-κB signaling is limited by classical NF-κB activity.Noncanonical NF-κB pathway controls the production of type I interferons in antiviral innate immunity.NF-κB inducing kinase: a key regulator in the immune system and in cancerTargeting BAFF in autoimmunity.Non-canonical NF-κB signaling pathway.The kinase NIK as a therapeutic target in multiple myeloma.
P2860
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P2860
NIK overexpression amplifies, whereas ablation of its TRAF3-binding domain replaces BAFF:BAFF-R-mediated survival signals in B cells.
description
2008 nî lūn-bûn
@nan
2008年の論文
@ja
2008年論文
@yue
2008年論文
@zh-hant
2008年論文
@zh-hk
2008年論文
@zh-mo
2008年論文
@zh-tw
2008年论文
@wuu
2008年论文
@zh
2008年论文
@zh-cn
name
NIK overexpression amplifies, ...... d survival signals in B cells.
@en
type
label
NIK overexpression amplifies, ...... d survival signals in B cells.
@en
prefLabel
NIK overexpression amplifies, ...... d survival signals in B cells.
@en
P2093
P2860
P50
P356
P1476
NIK overexpression amplifies, ...... d survival signals in B cells.
@en
P2093
Dinis P Calado
Marc Schmidt-Supprian
Shin-ichi Nishikawa
Yoshiteru Sasaki
Yuri Shimizu
P2860
P304
10883-10888
P356
10.1073/PNAS.0805186105
P407
P577
2008-07-28T00:00:00Z