The geometry of DNA supercoils modulates topoisomerase-mediated DNA cleavage and enzyme response to anticancer drugs.
about
Voreloxin is an anticancer quinolone derivative that intercalates DNA and poisons topoisomerase IIDNA Topoisomerase I Inhibitors: Chemistry, Biology, and Interfacial InhibitionSingle-Molecule Supercoil Relaxation Assay as a Screening Tool to Determine the Mechanism and Efficacy of Human Topoisomerase IB Inhibitors.Cytotoxic effects of human calprotectin on gastric cancer cell line is attenuated by etoposide.The dynamic interplay between DNA topoisomerases and DNA topology.Increased negative supercoiling of mtDNA in TOP1mt knockout mice and presence of topoisomerases IIα and IIβ in vertebrate mitochondria.Cleavage of plasmid DNA by eukaryotic topoisomerase II.Catalytic core of human topoisomerase IIα: insights into enzyme-DNA interactions and drug mechanismThe geometry of DNA supercoils modulates the DNA cleavage activity of human topoisomerase IInteractions between the etoposide derivative F14512 and human type II topoisomerases: implications for the C4 spermine moiety in promoting enzyme-mediated DNA cleavageAmsacrine as a topoisomerase II poison: importance of drug-DNA interactions.Tryptophane-205 of human topoisomerase I is essential for camptothecin inhibition of negative but not positive supercoil removalTyrosyl-DNA phosphodiesterase as a target for anticancer therapyAbility of viral topoisomerase II to discern the handedness of supercoiled DNA: bimodal recognition of DNA geometry by type II enzymes.DNA topoisomerase II, genotoxicity, and cancerBimodal recognition of DNA geometry by human topoisomerase II alpha: preferential relaxation of positively supercoiled DNA requires elements in the C-terminal domainDNA topoisomerases: harnessing and constraining energy to govern chromosome topology.Hyperphosphorylation of RNA polymerase II in response to topoisomerase I cleavage complexes and its association with transcription- and BRCA1-dependent degradation of topoisomerase I.Topoisomerase IB-DNA interactions: X marks the spotDNA cleavage assay for the identification of topoisomerase I inhibitors.Activities of gyrase and topoisomerase IV on positively supercoiled DNA.The Dynamic Interplay Between DNA Topoisomerases and DNA Topology.
P2860
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P2860
The geometry of DNA supercoils modulates topoisomerase-mediated DNA cleavage and enzyme response to anticancer drugs.
description
2006 nî lūn-bûn
@nan
2006年の論文
@ja
2006年論文
@yue
2006年論文
@zh-hant
2006年論文
@zh-hk
2006年論文
@zh-mo
2006年論文
@zh-tw
2006年论文
@wuu
2006年论文
@zh
2006年论文
@zh-cn
name
The geometry of DNA supercoils ...... response to anticancer drugs.
@en
type
label
The geometry of DNA supercoils ...... response to anticancer drugs.
@en
prefLabel
The geometry of DNA supercoils ...... response to anticancer drugs.
@en
P2860
P356
P1433
P1476
The geometry of DNA supercoils ...... response to anticancer drugs.
@en
P2093
A Kathleen McClendon
Neil Osheroff
P2860
P304
P356
10.1021/BI051987Q
P407
P577
2006-03-01T00:00:00Z