about
Sending Out an SOS: Mitochondria as a Signaling HubPotent and selective chemical probe of hypoxic signalling downstream of HIF-α hydroxylation via VHL inhibitionMitochondrial dysfunction remodels one-carbon metabolism in human cellsGenome engineering of stem cell organoids for disease modeling.Hypoxia treatment reverses neurodegenerative disease in a mouse model of Leigh syndrome.Effects of Acute Hypoxia and Reoxygenation on Physiological and Immune Responses and Redox Balance of Wuchang Bream (Megalobrama amblycephala Yih, 1955)HIF-1-mediated suppression of mitochondria electron transport chain function confers resistance to lidocaine-induced cell death.Synaptic Activity Drives a Genomic Program That Promotes a Neuronal Warburg Effect.Genome-scale CRISPR-Cas9 knockout and transcriptional activation screeningMitochondrial retrograde signaling in the Drosophila nervous system and beyond.MtDNA analysis reveals enriched pathogenic mutations in Tibetan highlanders.Medical gases for stroke therapy: summary of progress 2015-2016.The NAD+-Dependent Family of Sirtuins in Cerebral Ischemia and Preconditioning.Mitochondrial Protein Lipoylation and the 2-Oxoglutarate Dehydrogenase Complex Controls HIF1α Stability in Aerobic Conditions.Cytochrome c Oxidase Activity Is a Metabolic Checkpoint that Regulates Cell Fate Decisions During T Cell Activation and Differentiation.Review: Central nervous system involvement in mitochondrial diseaseMouse models for mitochondrial diseases.Calorie restriction in humans: An update.Redox Control of Skeletal Muscle Regeneration.Mitophagy in neurodegeneration and aging.Mitochondrial dysfunction and potential anticancer therapy.Increased mitochondrial fusion allows the survival of older animals in diverse C. elegans longevity pathways.Loss of Mitochondrial Ndufs4 in Striatal Medium Spiny Neurons Mediates Progressive Motor Impairment in a Mouse Model of Leigh Syndrome.Therapeutic effects of the mitochondrial ROS-redox modulator KH176 in a mammalian model of Leigh Disease.Changes in Choroidal Thickness follow the RNFL Changes in Leber's Hereditary Optic NeuropathyParadoxical Inhibition of Glycolysis by Pioglitazone Opposes the Mitochondriopathy Caused by AIF Deficiency.Hypoxia therapy--a new hope for the treatment of mitochondrial dysfunctions.Bacteria-mediated hypoxia functions as a signal for mosquito development.The role of declining adaptive homeostasis in ageing.Mitochondrial DNA density homeostasis accounts for a threshold effect in a cybrid model of a human mitochondrial disease.Oxygen, Metabolism, and Regeneration: Lessons from Mice.Hypoxia-induced transcription factor signaling is essential for larval growth of the mosquito Aedes aegypti.Loss of SLC25A46 causes neurodegeneration by affecting mitochondrial dynamics and energy production in mice.Am I ready for CRISPR? A user's guide to genetic screens.Group-Based Optimization of Potent and Cell-Active Inhibitors of the von Hippel-Lindau (VHL) E3 Ubiquitin Ligase: Structure-Activity Relationships Leading to the Chemical Probe (2S,4R)-1-((S)-2-(1-Cyanocyclopropanecarboxamido)-3,3-dimethylbutanoyl)-CRISPR/Cas9 library screening for drug target discovery.Target Discovery for Precision Medicine Using High-Throughput Genome Engineering.Towards an Understanding of Energy Impairment in Huntington's Disease Brain.Leigh syndrome in individuals bearing m.9185T>C MTATP6 variant. Is hyperventilation a factor which starts its development?Mitochondrial diseases: the contribution of organelle stress responses to pathology.
P2860
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P2860
description
2016 nî lūn-bûn
@nan
2016年の論文
@ja
2016年論文
@yue
2016年論文
@zh-hant
2016年論文
@zh-hk
2016年論文
@zh-mo
2016年論文
@zh-tw
2016年论文
@wuu
2016年论文
@zh
2016年论文
@zh-cn
name
Hypoxia as a therapy for mitochondrial disease.
@en
type
label
Hypoxia as a therapy for mitochondrial disease.
@en
prefLabel
Hypoxia as a therapy for mitochondrial disease.
@en
P2093
P2860
P356
P1433
P1476
Hypoxia as a therapy for mitochondrial disease
@en
P2093
Feng Zhang
Harveen Dhillon
Kristen Alexa
Luca Zazzeron
Neville E Sanjana
Olga Goldberger
Ophir Shalem
Rahul Goli
Stephanie Schatzman-Bone
P2860
P356
10.1126/SCIENCE.AAD9642
P407
P577
2016-02-25T00:00:00Z