The UHRF family: oncogenes that are drugable targets for cancer therapy in the near future?
about
PHD finger recognition of unmodified histone H3R2 links UHRF1 to regulation of euchromatic gene expressionIdentification of a novel, widespread, and functionally important PCNA-binding motifNIRF/UHRF2 occupies a central position in the cell cycle network and allows coupling with the epigenetic landscapeModification by ubiquitin-like proteins: significance in apoptosis and autophagy pathwaysStructure and Hemimethylated CpG Binding of the SRA Domain from Human UHRF1Structural Insight into Coordinated Recognition of Trimethylated Histone H3 Lysine 9 (H3K9me3) by the Plant Homeodomain (PHD) and Tandem Tudor Domain (TTD) of UHRF1 (Ubiquitin-like, Containing PHD and RING Finger Domains, 1) ProteinThe PHD Finger of Human UHRF1 Reveals a New Subgroup of Unmethylated Histone H3 Tail ReadersSignalling pathways in UHRF1-dependent regulation of tumor suppressor genes in cancerConserved linker regions and their regulation determine multiple chromatin-binding modes of UHRF1Cooperative DNA and histone binding by Uhrf2 links the two major repressive epigenetic pathwaysRAWUL: a new ubiquitin-like domain in PRC1 ring finger proteins that unveils putative plant and worm PRC1 orthologsDNA methylation in zebrafish.PHD fingers: epigenetic effectors and potential drug targetsIdentification and functional analysis of 9p24 amplified genes in human breast cancer.Aronia melanocarpa juice induces a redox-sensitive p73-related caspase 3-dependent apoptosis in human leukemia cells.ORTH/VIM proteins that regulate DNA methylation are functional ubiquitin E3 ligases.Upregulated UHRF1 promotes bladder cancer cell invasion by epigenetic silencing of KiSS1.Sensitivity to TOP2 targeting chemotherapeutics is regulated by Oct1 and FILIP1LUnexplored potentials of epigenetic mechanisms of plants and animals-theoretical considerations.Drugs and their molecular targets: an updated overview.Evidence that human blastomere cleavage is under unique cell cycle control.Down-regulation of UHRF1, associated with re-expression of tumor suppressor genes, is a common feature of natural compounds exhibiting anti-cancer propertiesFrequent SOCS3 and 3OST2 promoter methylation and their epigenetic regulation in endometrial carcinoma.Uhrf2 is important for DNA damage response in vascular smooth muscle cells.Genome-wide methylation and expression differences in HPV(+) and HPV(-) squamous cell carcinoma cell lines are consistent with divergent mechanisms of carcinogenesis.DNA methyltransferase 1 and DNA methylation patterning contribute to germinal center B-cell differentiation.UHRF1 phosphorylation by cyclin A2/cyclin-dependent kinase 2 is required for zebrafish embryogenesis.Analysis of UHRF1 expression in human ovarian cancer tissues and its regulation in cancer cell growth.Regulation of let-7 and its target oncogenes (Review)UHRF1 promotes proliferation of gastric cancer via mediating tumor suppressor gene hypermethylation.Epigenetic mechanisms in anti-cancer actions of bioactive food components--the implications in cancer preventionDigging deep into "dirty" drugs - modulation of the methylation machinery.An integrated genomic analysis of Tudor domain-containing proteins identifies PHD finger protein 20-like 1 (PHF20L1) as a candidate oncogene in breast cancerThe prognostic value of UHRF-1 and p53 in gastric cancer.UHRF2, a ubiquitin E3 ligase, acts as a small ubiquitin-like modifier E3 ligase for zinc finger protein 131.Hemi-methylated DNA opens a closed conformation of UHRF1 to facilitate its histone recognition.Limoniastrum guyonianum aqueous gall extract induces apoptosis in human cervical cancer cells involving p16 INK4A re-expression related to UHRF1 and DNMT1 down-regulation.Negative regulation of the acetyltransferase TIP60-p53 interplay by UHRF1 (ubiquitin-like with PHD and RING finger domains 1).Multidimensional Proteomics Reveals a Role of UHRF2 in the Regulation of Epithelial-Mesenchymal Transition (EMT).Intranuclear degradation of polyglutamine aggregates by the ubiquitin-proteasome system.
P2860
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P2860
The UHRF family: oncogenes that are drugable targets for cancer therapy in the near future?
description
2007 nî lūn-bûn
@nan
2007年の論文
@ja
2007年論文
@yue
2007年論文
@zh-hant
2007年論文
@zh-hk
2007年論文
@zh-mo
2007年論文
@zh-tw
2007年论文
@wuu
2007年论文
@zh
2007年论文
@zh-cn
name
The UHRF family: oncogenes tha ...... er therapy in the near future?
@en
type
label
The UHRF family: oncogenes tha ...... er therapy in the near future?
@en
prefLabel
The UHRF family: oncogenes tha ...... er therapy in the near future?
@en
P2093
P1476
The UHRF family: oncogenes tha ...... er therapy in the near future?
@en
P2093
Hideyuki Saya
Mayada Achour
Thierry Chataigneau
Valérie B Schini-Kerth
Yoshimi Arima
P304
P356
10.1016/J.PHARMTHERA.2007.06.003
P577
2007-06-22T00:00:00Z