Cooperative DNA and histone binding by Uhrf2 links the two major repressive epigenetic pathways
about
Modifiers and Readers of DNA Modifications and Their Impact on Genome Structure, Expression, and Stability in DiseaseNIRF/UHRF2 occupies a central position in the cell cycle network and allows coupling with the epigenetic landscapeUnlocking epigenetic codes in neurogenesisDNA methylation, its mediators and genome integrityConserved linker regions and their regulation determine multiple chromatin-binding modes of UHRF1Versatile toolbox for high throughput biochemical and functional studies with fluorescent fusion proteinsIntrinsic and extrinsic connections of Tet3 dioxygenase with CXXC zinc finger modulesPoly(ADP-ribose) polymerase 1 (PARP1) associates with E3 ubiquitin-protein ligase UHRF1 and modulates UHRF1 biological functionsGlobal DNA hypomethylation prevents consolidation of differentiation programs and allows reversion to the embryonic stem cell state.Uhrf2 is important for DNA damage response in vascular smooth muscle cells.Understanding the relationship between DNA methylation and histone lysine methylation.S phase-dependent interaction with DNMT1 dictates the role of UHRF1 but not UHRF2 in DNA methylation maintenanceHemi-methylated DNA opens a closed conformation of UHRF1 to facilitate its histone recognition.Negative regulation of DNMT3A de novo DNA methylation by frequently overexpressed UHRF family proteins as a mechanism for widespread DNA hypomethylation in cancer.Zinc Finger Protein 618 Regulates the Function of UHRF2 (Ubiquitin-like with PHD and Ring Finger Domains 2) as a Specific 5-Hydroxymethylcytosine ReaderE3 ligase UHRF2 stabilizes the acetyltransferase TIP60 and regulates H3K9ac and H3K14ac via RING finger domain.Neonatal genome-wide methylation patterns in relation to birth weight in the Norwegian Mother and Child Cohort.The role of methyl-binding proteins in chromatin organization and epigenome maintenance.Systematic analysis of histone modification readout.Interpreting the language of histone and DNA modifications.The 5-Hydroxymethylcytosine (5hmC) Reader UHRF2 Is Required for Normal Levels of 5hmC in Mouse Adult Brain and Spatial Learning and Memory.DNA methylation requires a DNMT1 ubiquitin interacting motif (UIM) and histone ubiquitinationEpigenetic mechanisms in neurogenesis.Proteins That Read DNA Methylation.The nuclear protein UHRF2 is a direct target of the transcription factor E2F1 in the induction of apoptosisUHRF2 decreases H3K9ac expression by interacting with it through the PHD and SRA/YDG domain in HepG2 hepatocellular carcinoma cells.Loss of UHRF2 expression is associated with human neoplasia, promoter hypermethylation, decreased 5-hydroxymethylcytosine, and high proliferative activity.Depletion of Uhrf1 inhibits chromosomal DNA replication in Xenopus egg extracts.Tet oxidizes thymine to 5-hydroxymethyluracil in mouse embryonic stem cell DNA.UHRF2 regulates local 5-methylcytosine and suppresses spontaneous seizures.Uhrf2 deletion impairs the formation of hippocampus-dependent memory by changing the structure of the dentate gyrus.Comparative biochemical analysis of UHRF proteins reveals molecular mechanisms that uncouple UHRF2 from DNA methylation maintenance.DNA Methylation and Adult Neurogenesis.Chromatin structure and its chemical modifications regulate the ubiquitin ligase substrate selectivity of UHRF1
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Cooperative DNA and histone binding by Uhrf2 links the two major repressive epigenetic pathways
description
2011 թուականի Սեպտեմբերին հրատարակուած գիտական յօդուած
@hyw
2011 թվականի սեպտեմբերին հրատարակված գիտական հոդված
@hy
artículu científicu espublizáu en 2011
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im September 2011 veröffentlichter wissenschaftlicher Artikel
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scientific journal article
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vedecký článok (publikovaný 2011/09/01)
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vědecký článek publikovaný v roce 2011
@cs
wetenschappelijk artikel (gepubliceerd op 2011/09/01)
@nl
наукова стаття, опублікована у вересні 2011
@uk
مقالة علمية (نشرت في سبتمبر 2011)
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name
Cooperative DNA and histone bi ...... repressive epigenetic pathways
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Cooperative DNA and histone bi ...... repressive epigenetic pathways
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Cooperative DNA and histone bi ...... repressive epigenetic pathways
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type
label
Cooperative DNA and histone bi ...... repressive epigenetic pathways
@ast
Cooperative DNA and histone bi ...... repressive epigenetic pathways
@en
Cooperative DNA and histone bi ...... repressive epigenetic pathways
@nl
prefLabel
Cooperative DNA and histone bi ...... repressive epigenetic pathways
@ast
Cooperative DNA and histone bi ...... repressive epigenetic pathways
@en
Cooperative DNA and histone bi ...... repressive epigenetic pathways
@nl
P2093
P2860
P3181
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P1476
Cooperative DNA and histone bi ...... repressive epigenetic pathways
@en
P2093
Andrea Rottach
Carina Frauer
Christine S. Schmidt
Daniela Meilinger
Garwin Pichler
Heinrich Leonhardt
Karin Fellinger
Katrin Schneider
Patricia Wolf
P2860
P304
P3181
P356
10.1002/JCB.23185
P577
2011-09-01T00:00:00Z