From amino acids to heteroaromatics--thiopeptide antibiotics, nature's heterocyclic peptides.
about
Thiopeptide antibiotics: retrospective and recent advancesNMR structures of thiostrepton derivatives for characterization of the ribosomal binding siteConstraining cyclic peptides to mimic protein structure motifs.Identification of distinct thiopeptide-antibiotic precursor lead compounds using translation machinery assaysA simple reverse genetics approach to elucidating the biosynthetic pathway of nocathiacin.Identification and analysis of the biosynthetic gene cluster encoding the thiopeptide antibiotic cyclothiazomycin in Streptomyces hygroscopicus 10-22.Manipulation of thiocillin variants by prepeptide gene replacement: structure, conformation, and activity of heterocycle substitution mutants.Genetic interception and structural characterization of thiopeptide cyclization precursors from Bacillus cereus.Total synthesis of the ribosomally synthesized linear azole-containing peptide plantazolicin A from Bacillus amyloliquefaciens.Total Synthesis of Nosiheptide.From nature to the laboratory and into the clinicThirteen posttranslational modifications convert a 14-residue peptide into the antibiotic thiocillin.Thiopeptide biosynthesis featuring ribosomally synthesized precursor peptides and conserved posttranslational modifications.Differential effects of thiopeptide and orthosomycin antibiotics on translational GTPases.How thiostrepton was made in the laboratory.Recent advances in the chemistry and biology of naturally occurring antibiotics.How nature morphs peptide scaffolds into antibioticsThe art of total synthesis through cascade reactionsStreptolysin S-like virulence factors: the continuing sagA.Recent progress in coupling of two heteroarenes.Recent derivatives from smaller classes of fermentation-derived antibacterials.Asymmetric bioreduction of activated alkenes to industrially relevant optically active compounds.Biosynthesis of thiopeptide antibiotics and their pathway engineering.Thiopeptide engineering: a multidisciplinary effort towards future drugs.YcaO-Dependent Posttranslational Amide Activation: Biosynthesis, Structure, and Function.Natural [4 + 2]-Cyclases.Concise route to defined stereoisomers of the hydroxy acid of the chondramides.Antiplasmodial thiostrepton derivatives: proteasome inhibitors with a dual mode of action.Synthesis and antimicrobial activity of binaphthyl-based, functionalized oxazole and thiazole peptidomimetics.Synthesis of the heterocyclic core of the D-series GE2270.Oxidative dehydrogenation of C-C and C-N bonds: A convenient approach to access diverse (dihydro)heteroaromatic compounds.Mutagenesis of NosM Leader Peptide Reveals Important Elements in Nosiheptide BiosynthesisTotal synthesis and complete structural assignment of thiocillin I.A structure-activity relationship study on multi-heterocyclic molecules: two linked thiazoles are required for cytotoxic activity.Total synthesis and stereochemical assignment of baringolin.The C-terminal extended serine residue is absolutely required in nosiheptide maturation.Synthesis and antioxidant activity of bis and tris heterocycles.Copper-catalyzed oxidation of azolines to azoles.Construction of macrocyclic thiodepsipeptides: synthesis of a nosiheptide 'southern hemisphere' model system.The effect of ring size on the optical behavior of novel photochromic push-pull dyes.
P2860
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P2860
From amino acids to heteroaromatics--thiopeptide antibiotics, nature's heterocyclic peptides.
description
2007 nî lūn-bûn
@nan
2007年の論文
@ja
2007年論文
@yue
2007年論文
@zh-hant
2007年論文
@zh-hk
2007年論文
@zh-mo
2007年論文
@zh-tw
2007年论文
@wuu
2007年论文
@zh
2007年论文
@zh-cn
name
From amino acids to heteroarom ...... ature's heterocyclic peptides.
@en
type
label
From amino acids to heteroarom ...... ature's heterocyclic peptides.
@en
prefLabel
From amino acids to heteroarom ...... ature's heterocyclic peptides.
@en
P356
P1476
From amino acids to heteroarom ...... ature's heterocyclic peptides.
@en
P2093
Rachael A Hughes
P304
P356
10.1002/ANIE.200700728
P407
P577
2007-01-01T00:00:00Z