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Characterization of a mechanism-based inhibitor of NAD(P)H:quinone oxidoreductase 1 by biochemical, X-ray crystallographic, and mass spectrometric approachesInhibition of Hsp90 with resorcylic acid macrolactones: synthesis and binding studiesMechanism-Based Inhibition of Quinone Reductase 2 (NQO2): Selectivity for NQO2 over NQO1 and Structural Basis for Flavoprotein InhibitionTargeting the Hsp90 molecular chaperone with novel macrolactams. Synthesis, structural, binding, and cellular studiesSynthesis of 19-substituted geldanamycins with altered conformations and their binding to heat shock protein Hsp90Synthesis of macrolactam analogues of radicicol and their binding to heat shock protein Hsp90Solar photochemical oxidation of alcohols using catalytic hydroquinone and copper nanoparticles under oxygen: oxidative cleavage of lignin modelsA Concise Route to Pyridines from Hydrazides by Metal Carbene N−H Insertion, 1,2,4-Triazine Formation, and Diels−Alder Reaction19-substituted benzoquinone ansamycin heat shock protein-90 inhibitors: biological activity and decreased off-target toxicity.Seven-membered ring scaffolds for drug discovery: Access to functionalised azepanes and oxepanes through diazocarbonyl chemistry.Antitumor indolequinones induced apoptosis in human pancreatic cancer cells via inhibition of thioredoxin reductase and activation of redox signaling.Antitumour indolequinones: synthesis and activity against human pancreatic cancer cellsOxidative activation of antioxidant defence.A Novel Hsp90 Inhibitor Activates Compensatory Heat Shock Protein Responses and Autophagy and Alleviates Mutant A53T α-Synuclein Toxicity.Synthesis and evaluation of 3-aryloxymethyl-1,2-dimethylindole-4,7-diones as mechanism-based inhibitors of NAD(P)H:quinone oxidoreductase 1 (NQO1) activity.From amino acids to heteroaromatics--thiopeptide antibiotics, nature's heterocyclic peptides.Natural and synthetic quinones and their reduction by the quinone reductase enzyme NQO1: from synthetic organic chemistry to compounds with anticancer potential.The synthetic challenge of diazonamide A, a macrocyclic indole bis-oxazole marine natural product.Potent activity of indolequinones against human pancreatic cancer: identification of thioredoxin reductase as a potential target.Heat shock protein 90 controls HIV-1 reactivation from latency.Natural products containing a diazo group.Quinones as dienophiles in the Diels-Alder reaction: history and applications in total synthesis.A new route to α-carbolines based on 6π-electrocyclization of indole-3-alkenyl oximes.Fused imidazoles as potential chemical scaffolds for inhibition of heat shock protein 70 and induction of apoptosis. Synthesis and biological evaluation of phenanthro[9,10-d]imidazoles and imidazo[4,5-f][1,10]phenanthrolines.Synthesis and Intracellular Redox Cycling of Natural Quinones and Their Analogues and Identification of Indoleamine-2,3-dioxygenase (IDO) as Potential Target for Anticancer Activity.Benzofuran-, benzothiophene-, indazole- and benzisoxazole-quinones: excellent substrates for NAD(P)H:quinone oxidoreductase 1Indolequinone inhibitors of NRH:quinone oxidoreductase 2. Characterization of the mechanism of inhibition in both cell-free and cellular systems.Indolequinone antitumour agents: correlation between quinone structure and rate of metabolism by recombinant human NAD(P)H:quinone oxidoreductase.Development of indolequinone mechanism-based inhibitors of NAD(P)H:quinone oxidoreductase 1 (NQO1): NQO1 inhibition and growth inhibitory activity in human pancreatic MIA PaCa-2 cancer cells.Inhibition of Hsp90 with synthetic macrolactones: synthesis and structural and biological evaluation of ring and conformational analogs of radicicol.Gliotoxin is a dual inhibitor of farnesyltransferase and geranylgeranyltransferase I with antitumor activity against breast cancer in vivo.Novel quinolinequinone antitumor agents: structure-metabolism studies with NAD(P)H:quinone oxidoreductase (NQO1).Copper(II)-Mediated Synthesis of Indolequinones from Bromoquinones and Enamines.Potassium N-iodo p-toluenesulfonamide (TsNIK, Iodamine-T): a new reagent for the oxidation of hydrazones to diazo compoundsAmination of heteroaryl chlorides: palladium catalysis or SN Ar in green solvents?Synthesis of β-keto esters in-flow and rapid access to substituted pyrimidines.An improved route to 19-substituted geldanamycins as novel Hsp90 inhibitors--potential therapeutics in cancer and neurodegeneration.A short synthesis of the triazolopyrimidine antibiotic essramycin.Synthesis of an achiral isomer of lipoic acid as an anchor group for SAM formation on gold surfaces.Targeting the Hsp90 chaperone: synthesis of novel resorcylic acid macrolactone inhibitors of Hsp90.
P50
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P50
description
organic chemist
@en
scheikundige
@nl
name
Christopher J. Moody
@ast
Christopher J. Moody
@en
Christopher J. Moody
@es
Christopher J. Moody
@nl
Christopher J. Moody
@sl
type
label
Christopher J. Moody
@ast
Christopher J. Moody
@en
Christopher J. Moody
@es
Christopher J. Moody
@nl
Christopher J. Moody
@sl
prefLabel
Christopher J. Moody
@ast
Christopher J. Moody
@en
Christopher J. Moody
@es
Christopher J. Moody
@nl
Christopher J. Moody
@sl
P166
P1053
B-8102-2016
P106
P1153
35598287400
P21
P31
P3829
P496
0000-0003-0487-041X