Synthesis, Activity and Metabolic Stability of Non-Ribose Containing Inhibitors of Histone Methyltransferase DOT1L.
about
Targeting histone methylation for cancer therapy: enzymes, inhibitors, biological activity and perspectivesTargeting histone methyltransferases and demethylases in clinical trials for cancer therapyDOT1L inhibition sensitizes MLL-rearranged AML to chemotherapyDiscovery of Novel Dot1L Inhibitors through a Structure-Based Fragmentation ApproachA medicinal chemistry perspective for targeting histone H3 lysine-79 methyltransferase DOT1L.A convergent synthesis of carbocyclic sinefungin and its C5 epimer.Structure-guided DOT1L probe optimization by label-free ligand displacement.Targeting DOT1L and HOX gene expression in MLL-rearranged leukemia and beyond3-(Piperidin-4-ylmethoxy)pyridine Containing Compounds Are Potent Inhibitors of Lysine Specific Demethylase 1.DNA Methylation Targeting: The DNMT/HMT Crosstalk Challenge.SAM/SAH Analogs as Versatile Tools for SAM-Dependent Methyltransferases.Pharmacological inhibition of LSD1 for the treatment of MLL-rearranged leukemia.A chemical probe toolbox for dissecting the cancer epigenome.Optimization of a Fragment-Based Screening Hit toward Potent DOT1L Inhibitors Interacting in an Induced Binding Pocket.Nonclinical pharmacokinetics and metabolism of EPZ-5676, a novel DOT1L histone methyltransferase inhibitor.
P2860
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P2860
Synthesis, Activity and Metabolic Stability of Non-Ribose Containing Inhibitors of Histone Methyltransferase DOT1L.
description
2013 nî lūn-bûn
@nan
2013年の論文
@ja
2013年論文
@yue
2013年論文
@zh-hant
2013年論文
@zh-hk
2013年論文
@zh-mo
2013年論文
@zh-tw
2013年论文
@wuu
2013年论文
@zh
2013年论文
@zh-cn
name
Synthesis, Activity and Metabo ...... stone Methyltransferase DOT1L.
@en
type
label
Synthesis, Activity and Metabo ...... stone Methyltransferase DOT1L.
@en
prefLabel
Synthesis, Activity and Metabo ...... stone Methyltransferase DOT1L.
@en
P2093
P2860
P356
P1433
P1476
Synthesis, Activity and Metabo ...... stone Methyltransferase DOT1L.
@en
P2093
Lisheng Deng
Yongcheng Song
P2860
P304
P356
10.1039/C3MD00021D
P577
2013-05-01T00:00:00Z