The Lhs1/GRP170 chaperones facilitate the endoplasmic reticulum-associated degradation of the epithelial sodium channel
about
BiP and its nucleotide exchange factors Grp170 and Sil1: mechanisms of action and biological functionsThe Endoplasmic Reticulum Chaperone GRP170: From Immunobiology to Cancer TherapeuticsTorsins: not your typical AAA+ ATPasesConserved charged residues at the surface and interface of epithelial sodium channel subunits--roles in cell surface expression and the sodium self-inhibition responseThe BiP molecular chaperone plays multiple roles during the biogenesis of torsinA, an AAA+ ATPase associated with the neurological disease early-onset torsion dystonia.Epithelial sodium channel abundance is decreased by an unfolded protein response induced by hyperosmolalitySil1, a nucleotide exchange factor for BiP, is not required for antibody assembly or secretionExpression of three topologically distinct membrane proteins elicits unique stress response pathways in the yeast Saccharomyces cerevisiaeThe nucleotide exchange factors Grp170 and Sil1 induce cholera toxin release from BiP to enable retrotranslocation.Functional Roles of Clusters of Hydrophobic and Polar Residues in the Epithelial Na+ Channel Knuckle Domain.The Grp170 nucleotide exchange factor executes a key role during ERAD of cellular misfolded clients.The large Hsp70 Grp170 binds to unfolded protein substrates in vivo with a regulation distinct from conventional Hsp70s.Deletion of α-subunit exon 11 of the epithelial Na+ channel reveals a regulatory moduleRegulation of the Epithelial Na(+) Channel by Paraoxonase-2.A novel nanoparticle containing neuritin peptide with grp170 induces a CTL response to inhibit tumor growth.Interactions between intersubunit transmembrane domains regulate the chaperone-dependent degradation of an oligomeric membrane protein.A nucleotide exchange factor promotes endoplasmic reticulum-to-cytosol membrane penetration of the nonenveloped virus simian virus 40.The endosomal trafficking factors CORVET and ESCRT suppress plasma membrane residence of the renal outer medullary potassium channel (ROMK).Diminished Ost3-dependent N-glycosylation of the BiP nucleotide exchange factor Sil1 is an adaptive response to reductive ER stress.N-linked Glycans are Required on Epithelial Na+ Channel Subunits for Maturation and Surface Expression.
P2860
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P2860
The Lhs1/GRP170 chaperones facilitate the endoplasmic reticulum-associated degradation of the epithelial sodium channel
description
2013 nî lūn-bûn
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2013年の論文
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2013年論文
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2013年論文
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2013年論文
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2013年論文
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2013年論文
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2013年论文
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2013年论文
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2013年论文
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name
The Lhs1/GRP170 chaperones fac ...... the epithelial sodium channel
@en
type
label
The Lhs1/GRP170 chaperones fac ...... the epithelial sodium channel
@en
prefLabel
The Lhs1/GRP170 chaperones fac ...... the epithelial sodium channel
@en
P2093
P2860
P356
P1476
The Lhs1/GRP170 chaperones fac ...... the epithelial sodium channel
@en
P2093
Ankita Roy
Arohan R Subramanya
Bridget F Donnelly
Jeffrey L Brodsky
Lindsay Plavchak
Ossama B Kashlan
Teresa M Buck
Thomas R Kleyman
P2860
P304
18366-18380
P356
10.1074/JBC.M113.469882
P407
P577
2013-05-03T00:00:00Z