The Lrp4R1170Q Homozygous Knock-In Mouse Recapitulates the Bone Phenotype of Sclerosteosis in Humans.

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Life-Course Genome-wide Association Study Meta-analysis of Total Body BMD and Assessment of Age-Specific Effects.Maxillary Bone Regeneration Based on Nanoreservoirs Functionalized ε-Polycaprolactone Biomembranes in a Mouse Model of Jaw Bone Lesion.

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The Lrp4R1170Q Homozygous Knock-In Mouse Recapitulates the Bone Phenotype of Sclerosteosis in Humans.

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2017 nî lūn-bûn

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2017年の論文

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2017年論文

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2017年論文

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The Lrp4R1170Q Homozygous Knoc ...... pe of Sclerosteosis in Humans.

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The Lrp4R1170Q Homozygous Knoc ...... pe of Sclerosteosis in Humans.

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The Lrp4R1170Q Homozygous Knoc ...... pe of Sclerosteosis in Humans.

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P1476

The Lrp4R1170Q Homozygous Knoc ...... pe of Sclerosteosis in Humans.

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P2093

Anja Verhulst

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Annelies De Maré

http://www.w3.org/2001/XMLSchema#string

Benjamin Vervaet

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Ellen Steenackers

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Geert Mortier

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Gretl Hendrickx

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Igor Fijalkowski

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Patrick D'Haese

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Silke Peeters

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Stephan Sonntag

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P2860

Twenty bone-mineral-density loci identified by large-scale meta-analysis of genome-wide association studies

Increased bone density in sclerosteosis is due to the deficiency of a novel secreted protein (SOST)

Bone overgrowth-associated mutations in the LRP4 gene impair sclerostin facilitator function

Osteocyte control of bone formation via sclerostin, a novel BMP antagonist

LRP4 mutations alter Wnt/beta-catenin signaling and cause limb and kidney malformations in Cenani-Lenz syndrome

Bone dysplasia sclerosteosis results from loss of the SOST gene product, a novel cystine knot-containing protein

Lrp5 functions in bone to regulate bone mass

High bone mass in mice expressing a mutant LRP5 gene

Sclerostin binds to LRP5/6 and antagonizes canonical Wnt signaling

Wnt but not BMP signaling is involved in the inhibitory action of sclerostin on BMP-stimulated bone formation

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1739-1749

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scholarly article

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10.1002/JBMR.3160

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Wim Van Hul

Eveline Boudin

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2017-05-06T00:00:00Z

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28477420

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The Lrp4R1170Q Homozygous Knock-In Mouse Recapitulates the Bone Phenotype of Sclerosteosis in Humans.

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P2860

P2860

The Lrp4R1170Q Homozygous Knock-In Mouse Recapitulates the Bone Phenotype of Sclerosteosis in Humans.

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